Recombinant Human snRNA-activating protein complex subunit 1 (SNAPC1)

Code CSB-YP623083HU
MSDS
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Source Yeast
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Code CSB-EP623083HU
MSDS
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Source E.coli
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Code CSB-EP623083HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP623083HU
MSDS
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Source Baculovirus
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Code CSB-MP623083HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SNAPC1
Uniprot No.
Alternative Names
Proximal sequence element-binding transcription factor subunit gamma; PSE binding factor subunit gamma; PSE-binding factor subunit gamma; PTF subunit gamma; PTFgamma; Small nuclear RNA activating complex polypeptide 1; small nuclear RNA activating complex, polypeptide 1, 43kDa; Small nuclear RNA-activating complex polypeptide 1; Small nuclear RNA-activating protein complex, 43-KD subunit; SNAP43; SNAPc 43 kDa subunit; SNAPc subunit 1; Snapc1; SNPC1_HUMAN; snRNA activating protein complex 43 kDa subunit; snRNA activating protein complex subunit 1; snRNA-activating protein complex 43 kDa subunit; snRNA-activating protein complex subunit 1
Species
Homo sapiens (Human)
Expression Region
1-368
Target Protein Sequence
MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA LKDWDEVLKF QQDLVNAQHF DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK KIHRAEVTEE FKDPSDRVMK LITSDVLEEM LNVHDHYQNM KHVISVDKSK PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN DGEEKMEGNS QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE NESLSGTEFT ASKKRRKH
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Gene References into Functions
  1. Results from a study on gene expression variability markers in early-stage human embryos shows that is a putative expression variability marker as well as a differential gene expression marker for the 3-day, 8-cell embryo stage. PMID: 26288249
  2. SNAPC1 is a general transcriptional coactivator that functions through elongating RNAPII. PMID: 22966203
  3. CK2 may have the capacity to differentially regulate U1 and U6 transcription even though SNAP(C) is universally utilized for human snRNA gene transcription [SNAPC protein, also called PTF or PSE-binding transcription factor] PMID: 15955816
Subcellular Location
Nucleus.
Database Links

HGNC: 11134

OMIM: 600591

KEGG: hsa:6617

STRING: 9606.ENSP00000216294

UniGene: Hs.179312

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