Recombinant Mouse 14-3-3 protein epsilon (Ywhae)

1. Rod photoreceptors are enriched in YWHAE (14-3-3 epsilon). Immunohistochemistry revealed that 14-3-3 epsilon and 14-3-3 zeta exhibit unique distributions in photoreceptors with 14-3-3 epsilon restricted to the inner segment and 14-3-3 zeta localized to the outer segment. PMID: 29486162
2. Authors used 14-3-3epsilon (Ywhae) flox mice and found that 14-3-3epsilon deficiency results in an increase in neurite formation. PMID: 28173130
3. The complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors in mice. PMID: 27845227
4. 14-3-3epsilon might directly bind to CD13, which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis. PMID: 26208633
5. Data indicate that 14-3-3epsilon is required for the mitotic entry in the fertilized mouse eggs and responsible for sequestering the CDC25B in cytoplasm. Its binding to CDC25B-S321 phosphorylated by PKA induces mitotic arrest. PMID: 25059436
6. Ser321 of Cdc25B is the specific binding site for 14-3-3epsilon binding. PMID: 23326474
7. 14-3-3epsilon deletion did not appear to induce compensation by other 14-3-3 isoforms but led to ventricular noncompaction, resulting from a selective reduction in compact myocardium thickness. PMID: 23071090
8. 14-3-3epsilon haploinsufficiency decreased the incorporation of expanded ATXN1 into its large toxic complexes in the cerebellum but not in the brainstem, and the distribution of ATXN1's small and large native complexes differed significantly between two regions PMID: 21245341
9. 14-3-3 epsilon belongs to a regulatory protein family involved in important cellular processes, including those leading to neurodegenerative diseases, and thus its increased expression suggests a role of this protein in tuning microglia activation PMID: 22065591
10. The finding of this study suggested that dysfunction of the TH neuronal network caused by the deficit of 14-3-3 epsilon may have been involved in the pathophysiology of schizophrenia and correlated with a dysfunction in the DISC1 complex. PMID: 21458426
11. 14-3-3epsilon interacts directly with PDX-1 to regulate its cellular distribution in pancreatic beta cells. PMID: 21287435
12. overexpression of 14-3-3epsilon led to resistance to both rotenone and 1-methyl-4-phenylpyridinium (MPP(+)), while other isoforms were not protective against both toxins. PMID: 21152247
13. The appearance of 14-3-3 proteins in the cerebrospinal fluid is characteristic of some neurodegenerative conditions PMID: 11784696
14. 14-3-3epsilon is important for neuronal migration by binding to NUDEL and provide a molecular explanation for the differences in severity of human neuronal migration defects with 17p13.3 deletions PMID: 12796778
15. 14-3-3 adapter proteins may have a role in regulating CD81 signaling, possibly dependent on cellular redox PMID: 14966136
16. HSF1 associates with ERK1 and 14-3-3epsilon during heat shock to modulate the amplitude of the response and lead to efficient termination of HSP expression on resumption of growth conditions PMID: 15364926
17. UBPY is catalytically inhibited in a phosphorylation-dependent manner by 14-3-3s during the interphase, and this regulation is cancelled in the M phase. PMID: 17720156
18. aldosterone-induced 14-3-3 isoforms, beta and epsilon, interact with phospho-Nedd4-2 as an obligatory heterodimer, blocking its interaction with ENaC and thereby increasing apical ENaC density and sodium transport. PMID: 18687683

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KEGG: mmu:22627

STRING: 10090.ENSMUSP00000070993

UniGene: Mm.234700