Recombinant Mouse ATP-binding cassette sub-family C member 9 (Abcc9), partial

1. Cardiac SUR2A levels were significantly increased while Kir6.2 levels were not affected. Hypoxia did not induce phosphorylation of extracellular signal-regulated kinases (ERK1/2) or protein kinase B (Akt), but triggered phosphorylation of AMP activated protein kinase (AMPK). AICAR, an activator of AMPK, increased the level of SUR2A in H9c2 cells. We conclude that oxygen increases SUR2A level by activating AMPK. PMID: 28121062
2. K(ATP) channels seem to play an essential role in murine myometrial motility via activation of SUR2B and Kir6.2 PMID: 27086859
3. Data show that PI3K/Akt signalling pathway and lactate dehydrogenase (LDH) play a crucial role in increase of cardiac ATP-binding cassette transporter sub-family C member 9 (SUR2A) induced by in vivo exposure to 18% oxygen. PMID: 25576887
4. Sulfhydration of SUR2B subunit modifies tyrosine nitration of Kir6.1 subunit within the KATP channel complex. PMID: 25552582
5. ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant PMID: 24037327
6. In the absence of Abcc9, the newborn heart fails to transition normally from fetal to mature myocardial metabolism. PMID: 24648545
7. Native K(ATP) channels in mouse vas deferens myocytes are a heterocomplex of K(IR)6.1 channels and SUR2B subunits. PMID: 24117345
8. Report unique properties of the ATP-sensitive potassium channel in the mouse ventricular cardiac conduction system. PMID: 21984445
9. Results suggest that oral nicotinamide is a regulator of SUR2A expression and has a potential as a drug that can improve physical endurance in conditions where this effect would be desirable. PMID: 20731746
10. Cardioprotection observed in the SUR2m mice is associated with a protected mitochondrial phenotype resulting from enhanced K(+) conductance that partially dissipated mitochondrial membrane potential. PMID: 20935152
11. Our present study reinforces a role for the full-length SUR2 protein in cardioprotection. PMID: 20656890
12. Transgenic mice with a sole increase in SUR2A expression had also increased cardiac resistance to ischaemia-reperfusion. PMID: 20083200
13. results imply that specific activation domains stimulate transcription by binding to distinct Mediator subunits; activation by E1A and Elk-1 requires recruitment of Mediator to a promoter by binding to its Sur2 subunit [sur2] PMID: 11934987
14. The intermittent coronary artery vasospasm seen in Sur2(-/-) mice provides a model for the human disorder Prinzmetal variant angina and demonstrates that the SUR2 K(ATP) channel is a critical regulator of episodic vasomotor activity. PMID: 12122112
15. Kir 6.1 gene expression was upregulated by almost 22-fold, whereas SUR2B was downregulated by threefold after inflammation. Decreased motility of colon during inflammation may be associated with changes in transcriptional regulation of Kir 6.1 and SUR2B. PMID: 14962845
16. The dimerization induces the opening of the KATP channel, probably by causing a conformational change of SUR2x. PMID: 15258252
17. results support the hypothesis that the mouse adenovirus type 1 (MAV-1) E1A-mSur2 interaction is important in MAV-1 replication in mice PMID: 15731221
18. PGE(2) alters pacemaker currents by activating the ATP-dependent K(+) channels comprised of K(ir) 6.2-SUR 2B in interstitial cells of Cajal. PMID: 17167224
19. Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress. PMID: 17765261
20. These results indicate that different K(ATP) compositions may co-exist in cardiac sarcolemmal membrane. PMID: 18001767
21. The assembly of nucleotide binding domains NBD1 and NBD2 provides a molecular substrate that determines the optimal catalytic activity in SUR2A, establishing a paradigm for the structure-function relationship within the KATP channel complex. PMID: 18311911
22. SUR2 and Kir6.1 mRNAs were found to be the most abundant in ventricular fibroblasts. PMID: 19166858
23. Report impaired exercise tolerance and skeletal muscle myopathy in sulfonylurea receptor-2 mutant mice. PMID: 19675276
24. We identify a novel SUR2 IES variant in cardiac mitochondria and provide evidence that the variant-based channel can form an ATP-sensitive conductance and may contribute to cardioprotection PMID: 19797704

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KEGG: mmu:20928

STRING: 10090.ENSMUSP00000084805

UniGene: Mm.35670