Recombinant Mouse Alcohol dehydrogenase class-3 (Adh5)

1. Site-directed mutagenesis of Akt at Cys224 revealed that S-nitrosylation at this site was pivotal for the reduced phosphorylation at Akt Ser473, which led to impaired Akt signaling. Furthermore, on HHcy challenge, as compared with GSNOR(+/+)ApoE(-/-) littermate controls, GSNOR(-/-)ApoE(-/-) double knockout mice showed reduced T-cell activation with concurrent reduction of atherosclerosis. PMID: 29860106
2. Data (including data from studies using knockout and transgenic mice) suggest that obesity and diabetes are accompanied by decreases in GSNOR activity in hepatocytes engendering nitrosative stress; obesity promotes S-nitrosylation of lysosomal proteins in liver, thereby impairing lysosomal enzyme activities and compromising autophagy. PMID: 29074597
3. Report inhibition of GSNOR activity by nebivolol leading to accumulation of nitrosothiols in cells, and this is associated with an enhanced vasodilation by S-nitrosoglutathione. PMID: 26746429
4. Increased GSNOR expression during aging decreases S-nitrosation of CaMKIIalpha and reduces CaMKIIalpha synaptosomal accumulation. PMID: 28883020
5. These data indicate a role for GSNOR in the host response to malaria infection and suggest that strategies to disrupt its activity will improve clinical outcomes. PMID: 28674030
6. GSNOR may act as a "brake" on skeletal muscle contractile performance under physiological conditions by modulating nitrosylation/denitrosylation balance. PMID: 27412893
7. Loss of GSNOR confers enhanced post-MI cardiac regenerative activity, characterized by enhanced turnover of cardiomyocytes and cardiac stem cells. PMID: 26178404
8. Results show that ADH5 removes endogenous formaldehyde to prevent DNA adducts, and protects with FANCD2, hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage. PMID: 26412304
9. S-nitrosoglutathione reductase-dependent modification of PPARgamma alters the balance between adipocyte and osteoblast differentiation and provides checkpoint regulation of the lineage bifurcation of these 2 lineages. PMID: 25798618
10. These findings provide novel insights into the involvement of GSNOR and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states. PMID: 24684653
11. Overexpression of ADH5 reduces both development and adult neuronal differentiation of neurons. This effect depends on the catalytic activity of ADH5 and involves ADH5-mediated denitrosation of histone deacetylase 2 (HDAC2). PMID: 24895131
12. GSNOR appears to play a crucial role in controlling pulmonary and systemic infection by K. pneumoniae. PMID: 24239886
13. A critical role for GSNOR in maintaining genomic integrity. PMID: 23354311
14. This study suggests that S-nitrosoglutathione reductase degradation of S-nitrosoglutathione is a vital step in the expression of ventilatory roll-off PMID: 23183419
15. GSNOR deficiency has a role in hepatocarcinogenesis, which is prevented by iNOS inhibition PMID: 23440427
16. Increasing the denitrosylation capacity of cardiomyocytes, via cardiomyocyte-specific overexpression of GSNOR, protects against sepsis-induced myocardial depression. PMID: 23417863
17. Compared the protein expression profiles in the livers of wild-type and GSNOR-deficient (GSNOR(-/-) ) mice that were challenged with lipopolysaccharide; subsequently id'd 19 upregulated and 19 downregulated proteins in GSNOR(-/-) mice using mass spec. PMID: 22623366
18. These results indicate that systemic hemodynamic responses (vascular tone and cardiac contractility), both under basal conditions and after adrenergic activation, are regulated through concerted actions of NO synthase/GSNOR. PMID: 22366318
19. protection of AGT and resistance to nitrosamine-induced genotoxicity critically depends on GSNOR in hepatocytes PMID: 21385828
20. Data show that GSNO-R activity was elevated in lung homogenates from female compared to male mice. PMID: 21103380
21. GSNOR denitrosylates connexin 43 at the gap junctions between vascular epithelial and vascular smooth muscle cells. PMID: 21071693
22. GSNOR, likely through regulation of S-nitrosylation and apoptosis, physiologically plays a protective role in the development of the immune system. PMID: 20980633
23. Data suggest that GSNOR deficiency, through dysregulated S-nitrosylation, may promote hepatocellular carcinoma, possibly by inactivating a DNA repair system. PMID: 20371487
24. following allergen challenge, wild-type mice exhibiting airway hyperresponsivity have increased airway levels of the enzyme GSNO reductase (GSNOR) and are depleted of lung S-nitrosothiols (SNOs) PMID: 15919956
25. Mechanisms are presented through which nitric acid and S-glutathione mediate nitrosative stress, as well as the cellular pathways of protein S-nitrosylation and denitrosylation involving GSNO reductase. PMID: 19138101
26. GSNOR inhibitors to be novel tools for regulating nitric oxide bioactivity and assessing the role of SNOs in vivo. PMID: 19596685

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KEGG: mmu:11532

STRING: 10090.ENSMUSP00000005964

UniGene: Mm.3874