Recombinant Mouse Antigen peptide transporter 1 (Tap1), partial

1. TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors. PMID: 26784543
2. It transport class I antigens to cell surface of CD8 positive lymphocytes which have a vital role in liver inflammation like fructose-induced steatosis. PMID: 23488792
3. Knocking out Tap1 abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits. PMID: 23959708
4. Apoe(-/-)Tap1(-/-) mice develop atherosclerosis equal to Apoe(-/-) mice, indicating a minor role for CD8(+) T cells and TAP1-dependent antigen presentation in the disease process. PMID: 22479479
5. Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation. PMID: 22298786
6. Our data suggest that the normal influx of TAP-transported peptides in the ER during routine processing creates an efficient barrier for peptides from alternative processing routes. PMID: 21898382
7. A complete overview is presented of the applicability of herpesvirus-encoded TAP and tapasin inhibitors in mouse cells of different genetic background. PMID: 21292324
8. downregulation of expression in PBMC of chronic hepatitis B patients PMID: 20300807
9. Our results do not support a role for MHC class I (TAP1) in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons. PMID: 20147861
10. a new role for mouse TAP2 in stabilizing TAP1 protein expression is shown using the Jasmine strain; Jasmine has an A to C transversion in exon 5 of TAP2, resulting in a threonine to proline substitution at position 293 of the protein. PMID: 19721454
11. Allergen-specific CD8+ T cells were recruited to and specifically activated in the lungs of sensitized animals after allergen-aerosol challenge, a process that was dependent on a functional TAP complex PMID: 19815810
12. MHC conformational changes, revealed at molecular level, may influence the immunogenicity PMID: 11858821
13. Macrophages cross-presented p33-VLP normally in the absence of TAP. The TAP-dependent pathway of cross-presentation is therefore confined to DC while both macrophages and DC harbor the TAP-independent pathway. PMID: 11870626
14. A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression PMID: 12594855
15. Tap1 is required for class I major histocompatibility complex (MHC-I) to bind endoplasmic reticulum-derived stabilizing peptides to achieve stability needed for alternate MHC-I processing via peptide exchange in acidic vacuolar processing compartments. PMID: 12794107
16. Presensitization of TAP1-/- mice with H-2K(b) peptides accelerated the rejection of C57BL/6 (H-2(b)) skin grafts. PMID: 15194347
17. PSF1 is required for early embryogenesis PMID: 16287864
18. These data suggest that PSF1 and SLD5 may cooperate in the proliferation of immature cell populations. PMID: 16338220
19. role for TAP-1 in the induction of IFN-gamma-producing NK (naatural killer) cells and demonstration that NK cell licensing can influence host resistance to infection. PMID: 17923502
20. regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport by ERK map kinases requires TAP-NxT1 binding and the AU-rich element PMID: 18048358
21. PSF1 is required for acute proliferation of hematopoietic stem cells in the bone marrow of mice. PMID: 18984863
22. These data suggest that PSF1 is tightly regulated at the transcriptional level in stem cells. PMID: 19285009
23. The furin-mediated secretory pathway provides approximately one-third of all surface peptide/histocompatibility class I complexes in wild-type TAP-competent cells. PMID: 19752221

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KEGG: mmu:21354

STRING: 10090.ENSMUSP00000128401

UniGene: Mm.482076