Recombinant Mouse Apolipoprotein A-II (Apoa2)

1. Study reports a deterministic role for the B6 apoa2 gene polymorphism in respiratory rhythmogenesis. The in vivo inheritance pattern discloses a recessive effect of the B6 allele on the apnea phenotype, as the presence of both B6 alleles in the brain is required for transcript and trait expression; in contrast, apoa2 mRNA expression in the liver requires only one allele. PMID: 27756649
2. The C-terminal APOA2F peptide might inhibit further extension of amyloid fibrils by blocking the active ends of nuclei. PMID: 25675489
3. Data show that reticulum (ER) stress responses differed among tissues with extracellular AApoAII amyloid fibril deposition. PMID: 25545477
4. In vivo, neither C57 nor FVB apoA-II protein levels are affected by the absence of apoE, while an apoE/apoA-I double deficiency results in a 50% decrease of plasma FVB apoA-II but results in undetectable levels of C57 apoA-II in the plasma. PMID: 24520415
5. ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis. PMID: 21622630
6. Exacerbated hepatitis is observed in ApoA-II-deficient mice, indicating that ApoA-II plays a suppressive role in concanavalin A-induced hepatitis under physiological conditions. PMID: 21300819
7. Severe AApoAII deposits in the spleen, heart, skin, liver, and stomach were shown in the fish oil group compared with those in the butter and safflower oil groups (fish oil > butter > safflower oil group) PMID: 12562830
8. Apoa2 injected into mice induced amyloidosis. PMID: 15063745
9. tissue distribution, biochemical properties, and transmission of mouse type A AApoAII amyloid fibrils PMID: 15111306
10. the presence of apoA-II on HDL particles inhibits the ability of endothelial lipase to influence the metabolism of HDL in vivo PMID: 16877778
11. These studies indicate that increased levels of APOA2 protein lead to earlier and greater amyloid deposition and enhanced sensitivity to the transmission of amyloid fibrils in transgenic mice. PMID: 17468778
12. ApoAII is efficiently reabsorbed in kidney proximal tubules in relation to its plasma concentration PMID: 17652309
13. apoAII regulates the metabolism of triglyceride-rich lipoproteins, with HDL serving as a plasma reservoir of apoAII that is transferred to the triglyceride-rich lipoproteins in the same way as VLDL and chylomicrons acquire most of their apoCs from HDL PMID: 18160395
14. These results are compatible with a role for apolipoproteins in lipid metabolism and transport in the developing lung in association with the sex difference in surfactant lipid synthesis. PMID: 19106236
15. To understand the mechanism of amyloid fibril formation by apoA-II, we examined the polymerization of synthetic partial peptides of apoA-II in vitro. PMID: 19596087

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KEGG: mmu:11807

STRING: 10090.ENSMUSP00000005824

UniGene: Mm.389209