Recombinant Mouse Astrocytic phosphoprotein PEA-15 (Pea15)

1. Under conditions of reduced glucose, the PS1/gamma-secretase system decreases neuronal losses by suppressing miR-212 and increasing its target survival factor, PEA15. These observations have implications for mechanisms of neuronal death under conditions of reduced glucose and may provide targets for intervention in neurodegenerative disorders. PMID: 28855274
2. the neurological and neurochemical phenotype of transgenic mice overexpressing PED/PEA-15 (tgPED), were analyzed. PMID: 27426254
3. PEA-15 is a protective mediator in the vasculature and acts, at least in part, by inhibiting ERK1/2-dependent nuclear signaling in vascular smooth muscle cells during neointimal hyperplasia. PMID: 28893763
4. Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response. PMID: 26317969
5. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism PMID: 25489735
6. Activated astrocytes are known to clear the Abeta deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD). PMID: 25108202
7. Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) represses transcription of the ped/pea-15 gene. PMID: 23105093
8. The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation. PMID: 22105357
9. PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3-methyladenine rescued TGF-beta1 effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 effects in muscle. PMID: 22281705
10. Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2. PMID: 21780113
11. we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK pathways under gonadotropin releasing hormone stimulation PMID: 21436256
12. PEA-15 regulates T-cell proliferation PMID: 20354143
13. PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase. PMID: 20215547
14. Normal astrocytes express PEA-15 positive astrocytes in all areas of the adult mouse brain; PEA-15 positive astrocytes represent only a subpopulation in each region, the hippocampus being the most striking example of this heterogeneity. PMID: 15207344
15. Overexpression of PED/PEA-15 dysregulates beta-cell function and is sufficient to impair glucose tolerance in mice. PMID: 17327429
16. PEA-15 can integrate signal transduction to provide a specific physiological outcome from activation of the multipotent extracellular signal-regulated MAP kinase pathway. PMID: 18077417
17. disruption of the PED/PEA-15-PLD1 molecular interaction enhances insulin sensitivity in skeletal muscle cells PMID: 18541525
18. PTEN influences Fas signaling, at least in part, by regulating PEA-15 phosphorylation and activity that, in turn, regulate the ability of Bcl-2 to suppress Fas-induced apoptosis. PMID: 19103758
19. We suggest PEA-15 may be an essential regulator of ERK-dependent spatial learning. PMID: 19917132

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KEGG: mmu:18611

STRING: 10090.ENSMUSP00000013842

UniGene: Mm.544