Recombinant Mouse Baculoviral IAP repeat-containing protein 3(Birc3)

1. These data reveal how, upon XIAP deficiency, a TLR-TNF-TNFR2 axis drives cIAP1-TRAF2 degradation to allow TLR or TNFR1 activation of RIPK3-caspase-8 and IL-1beta. This mechanism may explain why XIAP-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations. PMID: 28723569
2. These results reveal an additional level of regulation of the stability and the activity of E2F1 by a non-degradative K63-poly-ubiquitination and uncover a novel function for the E3-ubiquitin ligase cIAP1. PMID: 28542143
3. Drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFalpha. PMID: 27129149
4. downregulation of cIAPs in PSC cholangiocytes may contribute to the development of the disease. Our results also indicate that inhibition of TRAIL signaling pathways may be beneficial in the treatment of PSC PMID: 28055006
5. We show that BIRC3 has a unique role in facilitating glioma progression from low- to high-grade PMID: 27074575
6. These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase signaling by suppressing Pellino 1-mediated K63-linked ubiquitination of cIAP2, K48-linked ubiquitination, and degradation of TRAF3. PMID: 27377744
7. Birc3-deficient mice are resistant to azoxymethane-sodium dodecyl sulfate-induced colitis-associated colorectal cancer. PMID: 26037070
8. c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. PMID: 26096449
9. Induction of cIAP2 expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit. PMID: 25501826
10. we show that cIAP1 regulates TNF-induced actin cytoskeleton reorganization through a cdc42-dependentpathway PMID: 24276241
11. cIAP2 (Birc3)-dependent antagonism of RIPK3-mediated programmed necrosis critically protects the host from influenza infection through maintenance of pulmonary tissue homeostasis. PMID: 24439895
12. cIAP-2 protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 MAPK and NF-kappaB. PMID: 23837962
13. these results show that the loss of cIAP1 protects skeletal muscle from the degenerative pathology resulting from systemic loss of dystrophin. PMID: 23184147
14. a molecular mechanism for cIAP1's regulation in the NOD2 signaling pathway PMID: 23109427
15. TWEAK, cIAP1, and noncanonical NF-kappaB signaling has roles in the regulation of myoblast fusion PMID: 23074266
16. NFATc1 mRNA expression is negatively regulated by inhibitor of apoptosis protein 1 during osteoclastogenesis. PMID: 23126497
17. cIAP2 expression protects macrophages from Rip1-dependent necroptotic cell death and facilitates pathogen control. PMID: 22576661
18. found that, despite extensive backcrossing into a C57BL/6 background, c-IAP1(-/-) animals are also deficient in caspase 11 PMID: 22332634
19. Our data demonstrate a novel effect of overexpressed BCL10 in the pathogenesis of high-grade MALT lymphoma by increasing expression of API2 and it then forming a protein complex with BCL10/caspase-8 leading to caspase-8 activity suppression. PMID: 21954216
20. Deficiency in cIAP1 (encoded by Birc2) or cIAP2 (Birc3) impaired caspase-1 activation after spontaneous or agonist-induced inflammasome assembly. PMID: 22195745
21. Data show that inhibitor-induced rapid degradation of cIAPs requires binding to TRAF2, and reveal an unexpected difference between cIAP1 and cIAP2. PMID: 21331077
22. one of the functions of cIAP1 when localized in the nucleus is to regulate E2F1 transcriptional activity. PMID: 21653699
23. cIAP1 protein protects cells from TNF-induced necrosis by preventing formation of the RIP1- RIP3-FADD necrosome. PMID: 21052097
24. Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization PMID: 21393245
25. In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.( PMID: 21339290
26. fundamental role for cIAP1/cIAP2 in regulating B-cell survival and responsiveness PMID: 21300983
27. Data suggest that the c-IAP2/MALT1 fusion protein activates NF-kappaB by two distinct mechanisms, and loss of c-IAP2 E3 activity in vivo is sufficient to induce abnormalities common to MALT lymphoma. PMID: 21048983
28. These findings identify critical role of cIAP1, cIAP2 and Yap1 co-expression in mammary carcinogenesis PMID: 20676140
29. TNF signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding PMID: 20356846
30. IAP1 is an ubiquitin protein ligase mediating ubiqitination of IAP2 and its subsequent degragation. PMID: 15798218
31. cIAP2 is critical in the maintenance of a normal innate immune inflammatory response. PMID: 16382159
32. Results showed distinct patterns of cIAP2 expression during embryogenesis PMID: 16699955
33. These results demonstrate that overexpression of IAP-2 renders the heart more resistant to apoptosis and ischemia/reperfusion injury. PMID: 17321613
34. c-IAP1 and c-IAP2 are required for TNFalpha-stimulated RIP1 ubiquitination and NF-kappaB activation. PMID: 18621737
35. murine cells lacking XIAP and c-IAP 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stumuli. PMID: 18684108
36. either cIAP1 or 2 is required for proper Rip1 polyubiquitination and NF-kappaB activation upon TNFalpha treatment PMID: 18697935
37. disruption of ubiquitin-conjugating enzyme binding, or dimerization, stabilizes IAP proteins against IAP antagonists in vivo PMID: 18784070
38. PERK activity inhibits the ER stress-induced apoptotic program through the induction of cellular inhibitor of apoptosis (cIAP1 and cIAP2) proteins PMID: 19029953
39. MMP13 expression enhances osteosarcoma cell survival and Birc2 and Birc3 enhance cell survival but only in osteosarcoma cells with the chromosome 9A1 amplicon. The genes Birc2 and Birc3 are potential oncogenic drivers in the chromosome 9A1 amplicon. PMID: 19276372
40. lts show that TAK1 deletion facilitates TRAIL-induced cell death by activating caspase through ROS and downregulation of cIAP, and inhibition of TAK1 can be an effective approach to increase TRAIL sensitivity. PMID: 19421137
41. cIAP1 and cIAP2 are E3 ubiquitin ligases that are required for receptor-interacting protein 2 ubiquitination and for nucleotide-binding and oligomerization signaling. PMID: 19464198
42. TRAF2 has anti-apoptotic signaling roles in addition to promoting NF-kappaB signaling and that efficient activation of NF-kappaB by TNFR1 requires the recruitment of cIAP1/2 by TRAF2. PMID: 19815541

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KEGG: mmu:11796

STRING: 10090.ENSMUSP00000013949

UniGene: Mm.2026