Recombinant Mouse Band 4.1-like protein 3 (Epb41l3), partial

Code CSB-YP895762MO
MSDS
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Source Yeast
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Code CSB-EP895762MO
MSDS
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Source E.coli
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Code CSB-EP895762MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP895762MO
MSDS
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Source Baculovirus
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Code CSB-MP895762MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Epb41l3
Uniprot No.
Alternative Names
Epb41l3; Dal1; Epb4.1l3; Kiaa0987Band 4.1-like protein 3; 4.1B; Differentially expressed in adenocarcinoma of the lung protein 1; DAL-1; DAL1P; mDAL-1) [Cleaved into: Band 4.1-like protein 3; N-terminally processed]
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.
Gene References into Functions
  1. This paper herein showed the immunolocalization and interaction proteins of MPP6 in the mouse small intestine, and also that 4.1B in epithelial cells was not essential for the sorting of MPP6. PMID: 26496923
  2. findings document novel, isoform-selective roles for 130-kDa 4.1B in adhesion, spreading, and migration of MEF cells by affecting actin organization PMID: 24381168
  3. The results of this study demonstrated that 4.1B is a key cytoskeletal scaffold for axonal adhesion molecules expressed in the juxtaparanodal and internodal domains that unexpectedly regulates myelin sheath thickness. PMID: 23109359
  4. in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber. PMID: 21966409
  5. Protein 4.1B plays a key role in ensuring the proper molecular compartmentalization of hemi-node-type region of axons of motor neurons. PMID: 21958379
  6. 4.1B plays a pivotal role in interactions between the paranodal AGSJs and axonal cytoskeleton. PMID: 21632923
  7. 4.1B was specifically and constantly expressed in the stereocilia tips during postnatal development. PMID: 19853587
  8. Protein 4.1B is localized in islets of Langerhans and may have a role in phenotypic transition from pancreatic adenoma to carcinoma. PMID: 14574582
  9. protein 4.1B in mouse small intestine & DAL-1 in human colon showed similar distributions in normal intestinal epithelial cells; expression reduced in intestinal carcinoma; may function in preventing malignant transformation of intestinal epithelial cells PMID: 15517334
  10. 4.1B regulates mammary epithelial cell proliferation during pregnancy and suggest that its loss may influence mammary carcinoma pathogenesis PMID: 16007173
  11. 4.1B gene is not required for normal development and 4.1B/Dal-1 does not function as a tumor suppressor gene PMID: 16260618
  12. suggest a more general role for Protein 4.1B as a negative regulator of cancer progression to metastatic disease PMID: 17640904
  13. We propose that the 4.1B-containing membrane skeleton may play a role in regulating the Na(+) and HCO(3)(-) reabsorption in S1-S2 proximal tubules. PMID: 17712176
  14. In this study, the expression of 4.1B and its interaction with tumor suppressor in lung cancer-1 were examined in rodent adrenal gland, and the involvement of 4.1B in tumorigenesis PMID: 19321127

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Subcellular Location
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell junction. Note=Detected in the cytoplasm of actively dividing cells.
Tissue Specificity
Detected in brain (at protein level). Highest expression in brain, lower in testis, adrenal gland, heart and kidney. Also present in muscle and epithelial cells. Isoform 1 is expressed in brain, isoform 2 is expressed in heart and isoform 3 is mostly expr
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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