Recombinant Mouse C-type natriuretic peptide (Nppc)

1. this study shows that Nppc induces sperm attraction for fertilization PMID: 28054671
2. E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2) PMID: 28277543
3. CNP activates bone turnover and remodeling in vivo and possibly accelerates fracture healing in a mouse model. PMID: 25860030
4. The up-to-day world-wide data about the structure, distribution, and physiological effects of the most poorly known among the natriuretic peptides--the C-type (CNP)--are summarized in the review. PMID: 26263678
5. Connexin mimetics directed against connexin-43 (Cx43 CMP) overcame NPPC-mediated meiotic arrest in both isolated cumulus oocyte complexes and antral follicles. PMID: 24804968
6. CNP/NPR-C pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders PMID: 25105365
7. Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium PMID: 24099862
8. CNP overexpression in chondrocytes can prevent endochondral growth delay and protect against cartilage damage in a mouse model of inflammatory arthritis. PMID: 24449577
9. Data suggest that intracerebroventricular administration of C-type natriuretic peptide (CNP-22 or CNP-53) has anorexigenic effect on hypothalamic neurons via activation of melanocortin/melanocortin receptor signal transduction. PMID: 23274904
10. CNP/NPR2 signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin/EGFR signaling pathway suppresses this signal by downregulating Nppc expression. PMID: 22987720
11. we show that CNP plays important region-specific roles in the GI tract of mice. PMID: 23127564
12. CNP secreted by growing follicles is capable of stimulating preantral and antral follicle growth PMID: 22595960
13. NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity. PMID: 22696190
14. GTP-binding protein betagamma subunit-dependent potentiation of TRPV1 as novel signaling cascades recruited by CNP in dorsal root ganglia neurons leads to enhanced nociceptor excitability and thermal hypersensitivity and increases neuronal firing frequency. PMID: 22933780
15. These results demonstrate that lbab/lbab is a novel mouse model of chondrodysplasia caused by insufficient CNP action on endochondral ossification. PMID: 22271248
16. findings show mural granulosa cells express Nppc mRNA; cumulus cells surrounding oocytes express mRNA of NPPC receptor NPR2; granulosa cell ligand NPPC and receptor NPR2 in cumulus cells prevent precocious meiotic maturation PMID: 20947764
17. Data show that the mortality of CNP knockout mice was greatly decreased by circulating CNP. PMID: 20610569
18. CNP is a new regulator of food intake and energy expenditure. PMID: 20555027
19. Increased accumulation of CIOR in response to CNP might be related to the stimulation of osteoblastic mineralization by CNP. PMID: 11870417
20. study provides in vivo and in vitro genetic evidence that Cyclic GMP-dependent protein kinase II plays a critical role in CNP-mediated endochondral ossification PMID: 12193576
21. REVIEW: Significance of C-type natriuretic peptide (CNP) in endochondral ossification: analysis of CNP knockout mice. PMID: 12434160
22. Nppc is induced in renal tubular epithelia and then in interstitial myofibroblasts after unilateral ureteral obstruction and was activated in Wnt4-expressing cells during nephrogenesis PMID: 12475749
23. ANP has a role in vasodilating responsiveness to endothelial NO in mice PMID: 12637561
24. alterations in the renal CNP/NPR-B system may be an important physiological adjustment when water is scarce PMID: 14613785
25. C-type natriuretic peptide has a role in vasorelaxation in renal resistance arteries and aortas PMID: 15093694
26. Expression of CNP together with potent NPR-B receptors suggests that in podocytes, CNP may act in an autocrine and/or paracrine manner. PMID: 15327393
27. in hypertrophied mice, diminished effects of NO or CNP on ventricular myocyte contraction are not due to changes in guanylyl cyclase activity. PMID: 15550520
28. A single nucleotide mutation of Nppc is associated with dwarfism in lbab/lbab mice PMID: 17439653
29. Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide. PMID: 17951249
30. Molecular modeling suggested that the conserved arginine is critical for binding to an equally conserved acidic pocket in NPR-B. These results indicate that reduced binding to and activation of NPR-B causes dwarfism in lbab(-/-) mice. PMID: 18554750
31. Results suggest that C-type natriuretic peptide is derived from Schwann cells and plays an important role for the development and function of nociceptive sensory neurones. PMID: 18752656
32. These results demonstrate that lbab/lbab mice have a hypomorphic mutation in the Nppc gene that is responsible for dwarfism caused by impaired endochondral ossification. PMID: 18775416
33. the secreted molecule C-type natriuretic peptide (CNP) induces a cGMP signaling cascade via its receptor particulate guanylyl cyclase Npr2 which is essential for sensory axon bifurcation at the dorsal root entry zone (DREZ) of the spinal cord PMID: 19805384

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KEGG: mmu:18159

STRING: 10090.ENSMUSP00000027449

UniGene: Mm.12802