Product Details

Purity

>85% (SDS-PAGE)

Target Names

Celsr3

Uniprot No.

Q91ZI0

Alternative Names

Celsr3Cadherin EGF LAG seven-pass G-type receptor 3

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Gene References into Functions

Celsr3 is dispensable for the patterning of central dorsal root ganglion projections, but it regulates for the fine mapping of sensory fibers in the gray matter, which is important for somatosensory processing. PMID: 28754314
Results suggest that Celsr3 and Fzd3 orchestrate the formation of a scaffold of pioneer neurons and their axons during embryogenesis. This scaffold extends from prethalamus to ventral telencephalon and subcortex, and steers reciprocal corticothalamic fibers. PMID: 27170656
Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of neural progenitor cell fate decisions via Notch activation. PMID: 26939553
Our results provide evidence that the Celsr3-Fzd3 pathway interacts with EphA-ephrinA reverse signaling to guide motor axons in the hindlimb. PMID: 25108913
The essential role of Celsr3 in globus pallidus development. PMID: 25113559
This study demonistrated that Celsr3/Foxg1 mutation mice show the spinal motor network does not mature fully in the absence of corticofugal connections, and that some motor function is preserved despite congenital absence of the corticospinal tract. PMID: 24012835
Celsr3 and Fzd3 are required during murine embryogenesis to specifically control the guidance and growth of enteric neuronal projections relative to the longitudinal and radial gut axes. PMID: 23478408
Celsr3/Foxg1 & Celsr3/Dlx mutant mice were hyperactive, learning- & memory-impaired. Celsr3/Foxg1 caused abnormal cytoarchitecture of CA1, CA3, & dentate gyrus. Celsr3|Dlx mildly affected hippocampal and extrinsic & intrinsic connectivity. PMID: 23035085
Celsr2 and Celsr3 control the development and function of ependymal cilia; findings suggest that planar cell polarity signaling is involved in ependymal cilia development and in the pathophysiology of hydrocephalus, and possibly other ciliopathies PMID: 20473291
Developmental expression profiles of Celsr (Flamingo) genes in the mouse PMID: 11850187
Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development PMID: 11891983
Celsr3 is crucial in axonal tract development. PMID: 15778712
observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals PMID: 18487195
The atypical cadherin Celsr3 regulates the development of the axonal blueprint. PMID: 18494256
The protocadherin Celsr3 gene is essential for both tangential and radial interneuron migrations in a class-specific manner. PMID: 19332558
These observations provide unequivocal in vivo evidence that heterotypic interactions between axons and guidepost cells govern axonal path formation in mammals, and that Celsr3 plays a key role in this process. PMID: 19349379

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 2 family, LN-TM7 subfamily

Tissue Specificity

Expressed in the CNS and in the eye.

Database Links

STRING: 10090.ENSMUSP00000024238

UniGene: Mm.39945

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Recombinant Mouse Cadherin EGF LAG seven-pass G-type receptor 3 (Celsr3), partial

Product Details

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Target Background

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