Recombinant Mouse Calbindin(Calb1)

Code CSB-YP004432MO
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Source Yeast
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Code CSB-EP004432MO
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Source E.coli
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Code CSB-EP004432MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004432MO
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Source Baculovirus
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Code CSB-MP004432MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Calb1
Uniprot No. P12658
Alternative Names Calb1; Calbindin; Calbindin D28; D-28K; PCD-29; Spot 35 protein; Vitamin D-dependent calcium-binding protein; avian-type
Species Mus musculus (Mouse)
Expression Region 2-261
Target Protein Sequence AESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELLQARKKA GLELSPEMKS FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQELDINN ITTYKKNIMA LSDGGKLYRT DLALILSAGD N
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Gene References into Functions
  1. These results suggest that CaBP-28k expression may regulate PrP(C) protein expression and these mice may be vulnerable to the influence of prion disease. PMID: 29541346
  2. This study investigated the distribution of Ca2+-binding proteins (CaBPs), such as calbindin D28k, parvalbumin, and calretinin, in the Superior Olivary Complex of the circling mouse on postnatal day 16. PMID: 29130968
  3. These findings suggest CB labels a heterogeneous group of interneurons in the ventral horn, some of which may process sensory information. Based on cellular position, CB expression may be a shared feature of subsets of interneurons arising from multiple ventral progenitor domains. PMID: 29090497
  4. Early-life stress suppressed calbindin levels in CA1 and dentate gyrus. Calbindin knockdown in CA1 interneurons preserved long-term memory even after an acute stress challenge. PMID: 29069596
  5. propose that chronic suppression of calbindin by DeltaFosB is one mechanism through which intermittent seizures drive persistent cognitive deficits in conditions accompanied by recurrent seizures PMID: 29035369
  6. Our results demonstrate that fear memory and social behavior are altered in male knockout mice, and Calb1 KO mice of both sexes show less anxiety. Moreover, gene expression studies of the amygdala and prefrontal cortex revealed several significant genotype and sex effects in genes related to brain-derived neurotrophic factor signaling, hormone receptors, histone deacetylases, and gamma-aminobutyric acid signaling. PMID: 27010449
  7. Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200, and calbindin in mouse motor neurons. PMID: 28091925
  8. Calbindin D-28k plays an important role in gene expression of distal kidney tubule Ca, but not Mg, transport molecules. PMID: 26582761
  9. These results indicate that changes of CB protein expression may be associated with no neuronal death in the model of neuroinflammation with systemic administration of 1 mg/kg LPS. PMID: 25428702
  10. removal of Calbindin-D28k from amyloid precursor protein/presenilin transgenic mice aggravates Alzheimer disease pathogenesis, suggesting that Calbindin-D28k has a critical role in Alzheimer disease pathogenesis. PMID: 24853300
  11. EF-hand Ca(2+) buffers regulate presynaptic IHC function for metabolically efficient sound coding. PMID: 25691754
  12. The number of calbindin-expressing interneurons was maximal in the plate II at all levels of the spinal cord. PMID: 25697007
  13. Overexpression of CaBP-28 k could provide protection for dopaminergic neurons from neurodegeneration. PMID: 22923348
  14. A decrease in calbindin D28-k expression is found in the hippocampus of the circling mouse strain, a model of deafness. PMID: 22226504
  15. Our study provides further evidence for a critical role of CaB in spinocerebellar ataxia type 1 pathogenesis, which may help identify new therapeutic targets to treat SCA1 or other cerebellar ataxias PMID: 22076800
  16. The results demonstrate a consistent failure to maintain long-term potentiation (LTP) in hippocampal DG and CA1 area of calbindin 28K knockout mice. PMID: 22405690
  17. TRPV6, NCX1, and CaBP-9k in the fetal placenta and CaBP-28k in the maternal placenta may play key roles in controlling calcium transport across the placenta during pregnancy. PMID: 22407925
  18. Calbindin D-28k knockout mice showed accelerated age-dependent decline of metabolism in the dentate gyrus and age-independent enlarged hippocampus and neocortex as well as global brain hypertrophy. PMID: 21630373
  19. study demonstrates the active role played by CB-D(28k) in nociceptive sensory transmission. PMID: 22134771
  20. CaBP-28k blocks the up-regulation of apoptosis-related genes and ER stress genes, implying that CaBP-28k may decrease the expression of genes involved in apoptosis and ER stress in murine uterine tissue. PMID: 21882229
  21. Calbindin-D28k has a significant role in protecting dopaminergic cells against the apoptosis induced by the neurotoxin 6-hydroxydopamine PMID: 22020319
  22. Ureteral obstruction leads to the alteration of renal vitamin D metabolic enzyme expression and calcium transporter abundance, which may secondarily induce the abnormality of vitamin D endocrine system and bone health. PMID: 22029643
  23. Results describe the immunohistochemical expression of the calbindin D28K protein in the hippocampus of Fmr1 knockout mice and compare it with that of their wildtype littermates. PMID: 21491426
  24. findings show an important role for CalB in controlling photosensitivity in the non-image-forming visual system. PMID: 21545657
  25. in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau; an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin. PMID: 21531208
  26. The relative mean density of calbindin and parvalbumin immunoreactivity in the Purkinje cell layer is significantly decreased in the homozygous cir/cir genotype, compared with the wild-type. PMID: 20691752
  27. Impairment in cognitive functions and enhanced long-term potentiation are observed in association with increased calbindin D28K expression in the CA1 hippocampus of PS1-M146V mice. PMID: 20399254
  28. The diversity of calbindin-positive neurons in the mouse main olfactory bulb and their particular structural properties have been studied and described. PMID: 20406658
  29. mice lacking a functional Calb1 gene (Calb1(-/-)) had an increased phase-delay response to light applied at circadian time (CT) 14 PMID: 20205558
  30. calbindin D28-k and calretinin differences due to electromagnetic field exposure could cause changes in cellular Ca(2+)levels, which could have deleterious effect on normal hippocampal functions concerned with neuronal connectivity and integration. PMID: 19968972
  31. In choline deficiency, histone H3 was hypomethylated upstream of the RE1 binding site in the calbindin 1 promoter, and 1 CpG site within the calbindin 1 promoter was hypermethylated. PMID: 19752176
  32. Results demonstrate that transfection of calbindin-D(28k) gene into MCT cells provide protective effects against chemical hypoxic injury probably through its buffering effects on [Ca+2]i. PMID: 12052440
  33. The expression of CB and its colocalization with neuronal nitric oxide synthase have been determined in different populations of hippocampal GABAergic neurons. PMID: 12115690
  34. calbindin D-28k protects neurons from Ca(2+)-dependent L-glutamate-induced delayed cytotoxicity PMID: 12126880
  35. Nitric oxide synthase type 1 is first expressed in extrinsic nerve fibers in the vomeronasal nerve in the embryo. PMID: 12270041
  36. Calbindin D28K is expressed by the cell membrane in mouse chromaffin cells PMID: 12438114
  37. Levels of calbindin-D28k in beta-cells affect both intracellular Ca2+ concentration and insulin secretion in response to glucose. PMID: 12450313
  38. saturation of the endogenous fast Ca2+ buffer calbindin-D28k (CB) plays a major role in paired pulse facilitation at CB-containing synapses. PMID: 12691666
  39. Selective genetic deletion of the calcium-binding protein calbindin D-28k (calbindin) from cerebellar Purkinje cells results in deficits of motor coordination and sensory processing PMID: 12716955
  40. Distinct kinetics of parvalbumin and calbindin D28k underlie biphasic kinetics of synaptically evoked Ca2+ transients in dendritic shafts of Purkinje cells. PMID: 12813159
  41. requirement for CaBPs during the early phase of embryo implantation PMID: 15138301
  42. Calb expression in renal tubular cells provides cytoprotection against cyclosporine toxicity. PMID: 15254967
  43. plays a critical role in maintaining calcium homeostasis and skeletal mineralization PMID: 15456794
  44. calbindins are not required for active calcium transport PMID: 15494408
  45. These data suggest that calbindin-D28k equips hippocampal neurons with approximately 160 microM mobile, high-affinity Ca2+-binding sites that affect calcium signals. PMID: 15659591
  46. Results suggest that calbindin D28k acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound myo-inositol monophosphatase in central neurons. PMID: 15809430
  47. The increase in calbindin in striatal neurons of huntingtin-mutated mice was thus limited to the matrix compartment, and it may be triggered by increased Ca2+ entry due to the demonstrated heightened NMDA sensitivity of these neurons. PMID: 15990326
  48. These results demonstrate that the absence of the calbindin-28k disrupts the regulation of Purkinje cell firing rate and rhythmicity. PMID: 16115209
  49. Renshaw cells were identified immunohistochemically by their expression of calbindin and their location in the ventral horn of the spinal cord. PMID: 16460880
  50. Calcium-binding proteins may contribute to selective vulnerability and an early loss of function of large motor neurons in this SOD1-transgenic mouse model. PMID: 16546142

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Protein Families Calbindin family
Database Links

KEGG: mmu:12307

STRING: 10090.ENSMUSP00000029876

UniGene: Mm.277665

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