Recombinant Mouse Calcipressin-1 (Rcan1)

1. Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. PMID: 30442942
2. These findings demonstrate a novel regulatory role of RCAN1 in TLR signaling, which differentially regulates MyD88 and TRIF pathways. PMID: 29799862
3. The expression of DSCR1-4 increased strongly at P16 after OIR. There was no change in messenger RNA (mRNA) expression of DSCR1-1 at P16 after oxygen-induced retinopathy. The increased DSCR1 was mainly located in the RGCs of avascular retina. In addition, DSCR1-4 expression was increased in primary RGCs after hypoxia exposure. PMID: 27734335
4. The present study demonstrates that RCAN1 deficiency protects against Salmonella intestinal infection by enhancing proinflammatory JNK signaling. PMID: 27449908
5. DSCR1 as a key protein that couples axon growth. PMID: 27185837
6. from amongst the myriad of gene expression changes occurring in Type 2 diabetes (T2D) b-cells where we had little knowledge of which changes cause b-cell dysfunction, we applied a trisomy 21 screening approach which linked RCAN1 to b-cell mitochondrial dysfunction in T2D. PMID: 27195491
7. These results uncover a critical link between calcineurin signalling, impaired neurotrophin trafficking and neurodevelopmental deficits in the peripheral nervous system in Down syndrome. PMID: 26658127
8. Data suggest that expression of Dscr1 in hippocampus can be regulated by dietary factors; supplementation of maternal diet and offspring diet with fish oil down-regulates Dscr1 in hippocampus of offspring; Dscr1 is a presumed target in Down syndrome. PMID: 25799055
9. inhibition of the calcineurin-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo PMID: 25100642
10. PACAP targets RCAN1 to control neuronal differentiation. PMID: 26157140
11. We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin activity in HEK293T cells PMID: 25193101
12. Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion. PMID: 24838101
13. Data indicate that neuron from Down syndrome candidate region 1 (DSCR1)-transgenic mice were more resistant than wild-type neurons to apoptotic cell death following 24 h of glucose deprivation. PMID: 23144708
14. A major role for haematopoietic Rcan1 in atherosclerosis and suggest that therapies aimed at inhibiting RCAN1 expression or function might significantly reduce atherosclerosis burden. PMID: 24127415
15. SCF-mediated activation induced expression of Rcan1 in bone-marrow-derived mast cells. Rcan1 suppresses SCF-induced activation of calcineurin & NF-kappaB, & negatively regulates its own expression via Egr1. PMID: 24218457
16. dosage of DYRK1A and DSCR1 is critical for proper neurogenesis through NFATc and provide a potential mechanism to explain the neurodevelopmental defects in Down's syndrome PMID: 24352425
17. Suppression of tumor angiogenesis by an additional copy of Dscr1 contributes to the reduced cancer incidence in individuals with Down syndrome. PMID: 24051307
18. Rcan1 KO mice displayed reduced anxiety in several tests of unconditioned anxiety and lacked the early anxiogenic response to fluoxetine. PMID: 24155299
19. Trisomy of Dscr1 suppresses the progression of pancreatic intraepithelial neoplasia-1A (PanIN-1A) to PanIN-1B lesions without affecting the initiation of PanIN lesions mediated by oncogenic Kras(G12D). PMID: 24041692
20. study identifies a novel role for RCAN1 as a central regulator of inflammation during respiratory tract infection in vivo PMID: 23589609
21. a new regulatory mechanism of RCAN1 function PMID: 23118980
22. Increased RCAN1 expression may inhibit calcineurin activity to negatively regulate the amount of vesicle content released as well as impacting vesicle endocytosis and recycling. PMID: 23134420
23. Our data therefore identifies a novel molecular link between the overexpression of RCAN1 and pancreatic beta-cell dysfunction. PMID: 23011918
24. data strongly suggest that RCAN1 plays an important role in normal brain development and function and its up-regulation likely contributes to the neural deficits associated with Down syndrome PMID: 22511596
25. DSCR1 is a novel regulator of FMRP and Fragile X syndrome and Down syndrome may share disturbances in common pathways that regulate dendritic spine morphology and local protein synthesis PMID: 22863780
26. Data indicate normal diurnal corticosterone production in RCAN1 mutant mice and do not suggest a causal role in either the cognitive or anxiety phenotypes exhibited by RCAN1-knockout mice. PMID: 22546913
27. In this study we report that Rcan1-4 protein and mRNA levels are increased after brain ischemia/reperfusion injury in mice model. PMID: 22397398
28. a direct link between Dyrk1A and RCAN1 in the Caln-NFAT signaling and Tau hyperphosphorylation pathways PMID: 21965663
29. Rcan1 represents a novel contributor in the development of eosinophilia in allergic asthma through regulation of eosinophil progenitor production. PMID: 21741935
30. Results indicate that aneurysm formation and restenosis share mechanistic elements and identify Rcan1 as a potential therapeutic target for prevention of aneurysm and restenosis progression. PMID: 21930771
31. TgRCAN1 mice present a marked disruption of the learning process in a visuo-spatial learning task. PMID: 21364922
32. RCAN1 is involved in macrophage and the overall in vivo immune response, and plays an important role in cell immunity and infectious disease. PMID: 21073546
33. Profile adaptive pancreatic growth, identify Rcan1 as an important new feedback regulator, and firmly establish that calcineurin-NFAT signaling is required for this response. PMID: 20438729
34. CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4 PMID: 20371871
35. DSCR1 overexpression attenuates NFAT transcriptional activity in vascular smooth muscle cells. PMID: 19926569
36. MCIP1 can facilitate or suppress cardiac calcineurin signaling depending on the nature of the hypertrophic stimulus. PMID: 12515860
37. Calcipressins modulate the pattern of calcineurin-dependent transcription, and may influence calcineurin activity beyond calcium to integrate a broad array of signals into the cellular response. PMID: 12925851
38. Data show that Down syndrome critical region 1 expression is dependent on NFATc1 and support a role for DSCR1 in normal cardiac valvuloseptal formation and in the abnormal development of organ systems affected in individuals with Down syndrome. PMID: 14738882
39. expression of DSCR1 isoforms is elevated and NFAT transcriptional activity is decreased in the developing heart and brain PMID: 15906378
40. identified a small region of DSCR1 that is a potent inhibitor of calcineurin activity in vitro and in vivo PMID: 16131541
41. possibly the 1.5-fold increase in dosage of DSCR1 and DYRK1A cooperatively destabilizes a regulatory circuit, leading to reduced NFATc activity and many of the features of Down's syndrome PMID: 16554754
42. Modulatory calcineurin-interacting proteins serve either a permissive or facilitative function for calcineurin-nuclear factor of activated T cells signaling in vivo [Modulatory calcineurin-interacting protein 1 and 2] PMID: 16648267
43. Findings highlight the importance of RCAN1 gene dosage in the modulation of cell survival and death pathways and suggest that changes in the amount of RCAN1 could represent an important mechanism for regulating susceptibility to neurodegeneration. PMID: 17341486
44. DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation. PMID: 17693409
45. We thus show for the first time that ligand-induced growth cone collapse can activate both calcineurin- and calpain-mediated pathways concurrently. PMID: 17826176
46. These studies extend and complement previous studies on RCAN isoforms toward better understanding the role of RCAN1 in brain function and as a potential new target for treating calcineurin-related brain disorders. PMID: 17910944
47. This study propose a model in which RCAN1 plays a positive role in L-LTP and memory by constraining phosphatase signaling. PMID: 18045910
48. RCAN1 is a novel ATF6-inducible gene that may also be a novel integrator of growth and ER stress signaling in many other tissues that depend on calcineurin/NFAT signaling for optimal growth and development PMID: 18319259
49. Targeted deletion of Dscr1 leads to hyperactivated calcineurin and precocious endothelial apoptosis, inhibiting formation of an effective tumor vasculature and suppressing tumorigenesis. PMID: 18455125
50. Inflammatory mediators such as TNFalpha and IL-1beta can induce DSCR1-4 transcription, which may be associated with the alleviation of inflammatory processes. PMID: 18485347

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KEGG: mmu:54720

STRING: 10090.ENSMUSP00000060394

UniGene: Mm.265744