Recombinant Mouse Calpain-3 (Capn3), partial

1. Study shows that impaired skeletal muscle regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis. PMID: 29241457
2. calpain 3 is necessary for ubiquitination and that it acts upstream of the ubiquitination machinery PMID: 15961411
3. Cleavage of C-terminal titin by CAPN3 is associated with limb-girdle muscular dystrophy 2A and tibial muscular dystrophy. PMID: 25877298
4. these studies reveal a novel interaction between CAPN3 and CaM and identify CaM as the first positive regulator of CAPN3 activity. PMID: 25389288
5. our results suggest that a component of FSHD pathogenesis may arise by over-expression of FRG1, reducing Rbfox1 levels and leading to aberrant expression of an altered Calpain 3 protein through dysregulated splicing PMID: 23300487
6. The Ky gene was downregulated in CAPN3 knockout muscles suggesting that Ky protease may play a complementary role in regulating muscle cytoskeleton homeostasis in response to changes in muscle activity PMID: 22820870
7. stretch-induced dynamic redistribution of p94 is dependent on its protease activity and essential to protect muscle from degeneration PMID: 20592470
8. roles for Na(+) dependence of p94 PMID: 20460380
9. In vitro experiments have then revealed that only PDLIM1 is cleaved directly by calpain-3. PMID: 19926129
10. role in muscle maturation PMID: 12084932
11. C/EBP alpha is required for cleavage of cyclin A by calpain 3 in myeloid precursor cells. PMID: 12105198
12. several novel enzymatic properties of calpain 3 were identified PMID: 14594950
13. the Capn3 activation mechanism is similar to the universal activation of caspases and corresponds to an autolysis within the active site of the protease PMID: 14645524
14. Overexpression of CAPN3 exacerbates the muscular dystrophy with myositis , leading to a shorter life span and more severe muscular dystrophy. PMID: 16115818
15. Data suggested that sarcomeric localization of p94 is affected by the combination of contractile status of myofibrils, fiber type compositions, sarcomeric maturation, and the composition of the 'signal complexes' in each region. PMID: 16453164
16. the importance of p94-connectin interaction in the control of p94 functions by regulating autolytic decay of p94 PMID: 16627476
17. These data suggest that the persistence of fusion observed in C3KO cells inhibits subsequent steps of differentiation, such as integrin complex rearrangements and sarcomere assembly. PMID: 16982691
18. These studies are the first to identify possible substrates for CAPN3 in an in vivo system and support a role for CAPN3 in sarcomere remodeling by cleavage of myofibrillar proteins such as MLC1. PMID: 17051641
19. The new compound heterozygous mutations R147X/L212F cause increased autocatalytic activity. Since Arg147 is very close to the active site of the enzyme, R147X may affect the protease activity of calpain 3. L212F may affect the stability of this variant. PMID: 17594342
20. implicate the dynamic nature of connectin molecule as a regulatory scaffold of p94 functions PMID: 18310072
21. CAPN3 to be necessary for recruitment of AldoA to one specific location, namely the triads, which are structural components of muscle responsible for calcium transport and excitation-contraction coupling PMID: 18676612
22. calpain 3 is uniquely activated during lens fiber differentiation. PMID: 19269960
23. Mitochondrial abnormalities in the skeletal muscle of calpain 3 knockout mice correlate with the presence of oxidative stress. PMID: 19483197

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KEGG: mmu:12335

STRING: 10090.ENSMUSP00000028749

UniGene: Mm.458021