Recombinant Mouse Cathepsin D (Ctsd)

1. Study demonstrate that PGRN interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 aggregation observed in frontotemporal lobar degeneration with GRN mutations. PMID: 28493053
2. These results suggested that Purkinje cells (PCs) were more vulnerable to CTSD deficiency in lysosomes than to autophagy impairment, and this vulnerability does not depend on the severity of axonal swelling. PMID: 28502476
3. the cytosolic Cat D level and Cat D activity was significantly upregulated in response to oxygen-glucose deprivation/reperfusion exposure. PMID: 27573911
4. these results suggest that inhibition of lysosomal proteases, such as CtsD, could be a new therapeutic approach to reduce renal fibrosis and slow progression of chronic kidney disease. PMID: 26831567
5. The neuroectoderm specific cathepsin D (Ctsd) knock-out mice survived about 5.5 days longer. PMID: 26232697
6. Data indicate that cathepsin D (CD) protein is elevated in the retinas of diabetic mice and serum of human patients with diabetic macular edema (DME). PMID: 26718887
7. This study demonistrated that Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression. PMID: 26092248
8. Post-translational modifications drive CatD into the nucleus to cleave Histone 3 in the involuting mammary gland. PMID: 25054204
9. Increased lysosomal storage in CatD KO mice causes oxidative damage in brain pericytes, subsequently resulting in an increased vessel diameter and enhanced permeability of the BBB. PMID: 25496868
10. Mouse prolactin was proteolytically cleaved by Cath D between amino acids 148 and 149. N-terminal prolactin fragment and Cath D expression increased during mammary gland involution. PMID: 24598201
11. Cathepsin D was not inherent to sperm themselves, but rather of epididymal origin and was presumably transported to the sperm surface via epididymosomes. PMID: 23177142
12. TGase 2 may regulate the balance between cell survival and cell death through the modulation of CTSD levels. PMID: 21960143
13. These results suggest that increased release/activation of cathepsin D can trigger neurodegeneration and possibly development of Niemann-Pick type C disease pathology. PMID: 23250759
14. Relative position of thyroglobulin (Tg)peptide epitopes are identified based on homology to known Ctsd cleavage sites in rabbit Tg. PMID: 23315080
15. c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis. PMID: 22439866
16. the connection of STAT-1 and cathepsin-D in a single compartment is relevant for protection against listeriosis. PMID: 22337873
17. reduces the toxicity of advanced glycation end products PMID: 22245096
18. This data showed there was no correlation between mRNA expression and activity of beta-secretase, cathepsin D, and cathepsin B in the brain of SAMR1 and SAMP8 with age. PMID: 22008266
19. Data demonstrated that Abeta toxic species cross the plasma membrane, accumulate in cells and bind to a variety of internal proteins, vimentin (cytoskeleton), cathepsin D (lysosomes), GRP-78 (endoplasmic reticulum and associated membranes). PMID: 21966382
20. Processing and presentation of the soluble recombinant protein fragment of MSP1 is unaffected by the absence of cathepsin D, but is inhibited when both cathepsin D and E are absent. PMID: 22053177
21. cathepsin D regulates multiple proteins controlling the mitochondrial pathway of macrophage apoptosis or competing death processes, facilitating intracellular bacterial killing PMID: 21474794
22. Key role of cath-D in the control of adipogenesis, suggests that cath-D may be a novel target in obesity. PMID: 21311773
23. findings reveal that CatD undergoes distinct protein processing at different stages of mammary gland development PMID: 20592493
24. CathD promotes 'synucleinase' activity and enhancing its function may lower aSyn concentrations in vivo. PMID: 19203374
25. Extensive accumulation of endogenous alpha-syn was found in a mouse model of lysosomal enzyme cathepsin D (CD) deficiency. PMID: 19021916
26. Cathepsin D plays a significant role in the removal of AGE-modified proteins. PMID: 20560835
27. Data show that re-expression of cathepsin D (CtsD) within the CNS but not re-expression of CtsD in visceral organs prevented both central and visceral pathologies of CtsD(-/-) mice. PMID: 20489146
28. Dysmyelination and altered trafficking of cholesterol are evident in the brains of cathepsin D knockout mice; myelin-related proteolipid protein and myelin basic protein are both markedly reduced at postnatal day 24. PMID: 19845830
29. Findings show that cathepsin D is the main protease responsible for the generation of adenohypophyseal vasoinhibins and that its action can take place within the secretory granules of lactotrophs. PMID: 19819948
30. Cathepsin D is specifically inhibited by deoxyribonucleic acids. PMID: 12062453
31. cathepsin D increased markedly in brown adipocytes during differentiation PMID: 12117300
32. mutation at aspartic acid residue 293 may result in a conformational change which affects stability, processing and transport of the enzyme PMID: 12350228
33. Knockout mice without this protein show a new form of lysosomal accumulation disease with a phenotype resembling neuronal ceroid lipofuscinosis. PMID: 12440525
34. acid aspartate protease CTSD is linked to the mitochondrial apoptotic TNF pathway PMID: 14739942
35. Showed a functional link between cathepsin D activation, transglutaminase 1 activity and protein expression of cornified envelope proteins during epidermal differentiation. PMID: 15126630
36. IGF-II modulation of cathepsin D routing is IGF-II/M6P receptor mediated PMID: 15518240
37. In mouse spinal cord injury lead the up-regulation cathepsin D expression at 7 days and cathepsin D expression was observed in activated macrophages/microglia at 3 and 7 days. PMID: 15592854
38. In conclusion, results from our present study showed that Hyp mouse ObCs release a greater amount of Cat D, which may contribute to the inhibitory effect of Hyp mouse ObC-conditioned media on ObC mineralization. PMID: 15958652
39. Aspartyl protease substrate myoglobin requires cathepsin D activity for presentation to T cells. PMID: 16259009
40. Cathepsin D deficient mice could be useful animal models for neuronal ceroid-lipofuscinosis/Batten disease. PMID: 16314482
41. Ctsd is a bactericidal agent effective against the intracellular bacterium Listeria monocytogenes. A major target of cathepsin D is the main virulence factor listeriolysin O. PMID: 16424157
42. vacuolar proton ATPase-dependent phagosomal activation of Cat D was required for the generation of an antigen 85B epitope by macrophages PMID: 16920965
43. Cathepsin D secreted from various tissues is able to process PRL into 16K PRL outside the cell. PMID: 16959874
44. Study shows that female mice with a cardiomyocyte-specific deletion of stat3 develop postpartum cardiomyopathy; cardiac cathepsin D expression and activity is enhanced and associated with 16 kDa form of prolactin. PMID: 17289576
45. Abca1 expression is specifically regulated in hepatocytes, where Npc1 activity modulates cathepsin D expression and Abca1 protein translation rate PMID: 17553802
46. The somatosensory thalamocortical circuitry as a particular focus of pathologic changes and provide the first evidence for synaptic alterations at the molecular and ultrastructural levels in CTSD deficiency. PMID: 18091563
47. the entire 27-44 amino acid region of activation peptide is necessary for the stimulatory actions of procathepsin D on breast cancer cells PMID: 18202773
48. cathepsin D is the main lysosomal enzyme involved in alpha-synuclein degradation PMID: 18702517
49. Mannose receptor (-/-) liver sinusoidal endothelial cells had markedly and significantly reduced enzyme activities for four out of five lysosomal enzymes tested, i.e., cathepsin-D, alpha-mannosidase, beta-hexosaminidase and arylsulfatase. PMID: 19026003
50. necessary for hepatic stellate cell transdifferentiation into myofibroblasts PMID: 19116891

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KEGG: mmu:13033

STRING: 10090.ENSMUSP00000121203

UniGene: Mm.231395