Recombinant Mouse Coagulation factor XI (F11)

Code CSB-YP007916MO
MSDS
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Source Yeast
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Code CSB-EP007916MO
MSDS
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Source E.coli
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Code CSB-EP007916MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007916MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP007916MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
F11
Uniprot No.
Alternative Names
F11Coagulation factor XI; FXI; EC 3.4.21.27; Plasma thromboplastin antecedent; PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
Species
Mus musculus (Mouse)
Expression Region
19-389
Target Protein Sequence
EC VTKVFKDISF QGGDLSTVFT PSATYCRLVC THHPRCLLFT FMAESSSDDP TKWFACILKD SVTEILPMVN MTGAISGYSF KQCPQQLSTC SKDVYVNLDM KGMNYNSSVV KNARECQERC TDDAHCQFFT YATGYFPSVD HRKMCLLKYT RTGTPTTITK LNGVVSGFSL KSCGLSNLAC IRDIFPNTVL ADLNIDSVVA PDAFVCRRIC THHPTCLFFT FFSQAWPKES QRHLCLLKTS ESGLPSTRIT KSHALSGFSL QHCRHSVPVF CHPSFYNDTD FLGEELDIVD VKGQETCQKT CTNNARCQFF TYYPSHRLCN ERNRRGRCYL KLSSNGSPTR ILHGRGGISG YSLRLCKMDN VCTTKINPR
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Gene References into Functions
  1. FXI(-/-) mice have a mild hemostatic defect after injury to the saphenous vein but not after transection of the tail or vessels in the abdominal wall. PMID: 28677246
  2. FXI protects against sepsis derived from Streptococcus pneumoniae or Klebsiella pneumoniae pneumonia at least in part by enhancing the phagocytic capacity of neutrophils by a mechanism that is independent of activation via FXIIa. PMID: 28492700
  3. FXI attenuates part of the allergic response to repeated administration of house dust mite in the airways by a mechanism that is independent of activation via FXII. PMID: 27913422
  4. Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease. PMID: 26817955
  5. FXI deprivation was shown to slow down atherogenesis in Apoe knockout mice. PMID: 26800563
  6. anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin are also required for expression of polyP cofactor activity during FXI activation PMID: 24118982
  7. Factor XI antisense oligonucleotides safely prevent thrombus formation on acutely ruptured atherosclerotic plaques in mice. PMID: 24947525
  8. Studies indicate that targeting factor XI (FXI) by knocking out the gene prevents arterial and vein thrombosis. PMID: 23929304
  9. Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. PMID: 21724997
  10. fXI and fXII contribute to thrombus formation even when factor VIIa/tissue factor initiates thrombosis. PMID: 20634381
  11. Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development PMID: 11841337
  12. FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse. PMID: 12008966
  13. FIX and FXI deficiency cause similar effects in the carotid artery injury model PMID: 15733058
  14. fXI may have functions in regulation of inflammation or tissue repair distinct from its role in coagulation PMID: 15985536
  15. apolipoprotein E receptor 2 (ApoER2, LRP8), a member of the LDL receptor family, is a platelet receptor for FXI. PMID: 19661487

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Subcellular Location
Secreted.
Protein Families
Peptidase S1 family, Plasma kallikrein subfamily
Database Links
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