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| Code | CSB-YP005742MO |
| Product Type | Recombinant Protein |
| Size | US$2959 |
| Uniprot No. | P08122 |
| Relevance | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Species | Mus musculus (Mouse) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | VSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEEEIKPYISRCSVCEAPAVAIAVHSQDTSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYFANKYSFWLTTIPEQNFQSTPSADTLKAGLIRTHISRCQVCMKNL |
| Research Area | others |
| Source | Yeast |
| Gene Names | Col4a2 |
| Protein Names | Recommended name: Collagen alpha-2(IV) chain Cleaved into the following chain: 1. Canstatin |
| Expression Region | 1481-1707aa |
| Tag Info | N-terminal 6xHis-sumostar-tagged |
| Mol. Weight | 41.1 kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| References |
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| Function | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane |
| Protein Families | Type IV collagen family |
| Database Links |
KEGG: mmu:12827 STRING: 10090.ENSMUSP00000033899 UniGene: Mm.181021 |
| Pathway |
PI3K-Akt signaling pathway
Focal adhesion AGE-RAGE signaling pathway in diabetic complications |
Col4a2 Antibodies for Mus musculus (Mouse)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA005742ZA01MO | Col4a2 Antibody | Mus musculus | ELISA, WB (ensure identification of antigen) |
Col4a2 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP005742MO | Recombinant Mouse Collagen alpha-2(IV) chain(Col4a2),partial | E.coli |
| CSB-BP005742MO CSB-MP005742MO |
Recombinant Mouse Collagen alpha-2(IV) chain(Col4a2) ,partial | Baculovirus Mammalian cell |
Col4a2 ELISA Kit for Mus musculus (Mouse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL005742MO | Mouse Collagen alpha-2(IV) chain (COL4A2) ELISA kit | Request Information |
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