Recombinant Mouse Complement decay-accelerating factor, GPI-anchored (Cd55)

1. CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow. PMID: 27929130
2. regulates self-renewal and cisplatin resistance in endometrioid tumors PMID: 28838952
3. Results show that definitive endoderm (DE) expressing Daf1 are slowly proliferating and adhesive cells suggesting that Daf1 is a marker of late stage DE. PMID: 27245320
4. these data show a key role for HIF-1alpha in regulating the expression of CD55 on airway epithelium. PMID: 27494303
5. CD55 is produced by the synovium and deposited on local collagen fiber meshwork, where it protects against immune complex-mediated arthritis. PMID: 25596646
6. Fibrosis in Daf1-/- mice was accompanied by high expression of alpha-smooth muscle actin. PMID: 25032961
7. the downregulation of CD55 expression precedes, and has an important role regarding, the activation of C3 in the occurrence and development of DNP. PMID: 25377281
8. IFN-gamma-producing NKT cells enhance C5a generation via IL-10-mediated inhibition of CD55 expression on neutrophils, thereby exacerbating sepsis. PMID: 24723363
9. CD55 downregulates CD97 surface expression on circulating leukocytes by a process that requires physical forces. PMID: 23447688
10. Trypanosoma cruzi-inoculated DAF-deficient mice provide a useful model for studying T-cell mediated immunity in skeletal muscle tissues. PMID: 22987701
11. These data suggest that complement-independent interaction of CD55 with CD97 is functionally relevant and involved in granulocyte homeostasis and host defense. PMID: 21984892
12. DAF suppressed T-cell immunity as a complement regulator in the context of inflammation but did not play an intrinsic role on T cells or antigen-presenting cells PMID: 21652682
13. These data suggest an intriguing effect of reduced DAF expression on host responses following in vivo mouse cytomegalovirus infection. PMID: 21166665
14. Murine cytomegalovirus infection augments morbidity and mortality post-allo-bone marrow transplantion by reducing surface DAF expression. PMID: 20840652
15. DAF1 expression is maintained until differentiation day 12 in ES cell-derived definitive endoderm cells. PMID: 20526042
16. DAF has a role in conferring ocular immune privilege for successful corneal engraftment PMID: 20055803
17. These findings demonstrate that the absence of Daf1 exacerbates IFN-gamma-dependent murine mercury-induced autoimmunity (mHgIA), with changes in the profile of expressed cytokines. PMID: 20408894
18. Decay-accelerating factor control of C3a and C5a generation and prevention of the binding of these activation fragments to the C3a and C5a receptors are critical for the biological response to vascular injury. PMID: 20299685
19. Insight into a role for CD55 interaction with CD97 in the pathogenesis of rheumatoid arthritis suggest that therapeutic strategies that disrupt CD55/CD97 may be clinically beneficial. PMID: 20131275
20. dysfunction or down-regulation of CD55 may contribute to autoimmune disease pathogenesis and manifestation PMID: 12213736
21. Mice that lack DAF are markedly more susceptible to anti-AChR-induced myasthenia gravis. PMID: 12417565
22. In autoantibody-mediated nephritis, DAF serves as the primary barrier to classical complement pathway-mediated injury. PMID: 14764738
23. Study of Daf1 gene-targeted mice demonstrates that DAF-dependent C3 convertase control of complement is important in regulating gut homeostasis, and consequently its activity may participate in protecting against inflammatory bowel disease. PMID: 15004190
24. In a murine model using genetically engineered mice, CD55 plays a key role in preventing the initiation of the complement cascade after renal ischemia reperfusion injury. PMID: 15004194
25. These studies demonstrate the physiologic role of DAF in preventing humoral rejection in the presence of low levels of natural antibodies PMID: 16421483
26. CD55 has a role in prostate cancer growth and survival PMID: 16533428
27. A study evaluating whether H. pylori utilizes DAF as a receptor and the role of DAF within H. pylori-infected gastric mucosa is presented. PMID: 16543227
28. positive regulator of T cell immunity in Coxackievirus B3 myocariditis PMID: 16817758
29. DAF(high)-Crry(-/-) erythrocytes were significantly more resistant than either DAF(low)-Crry(-/-), DAF(-/-) -Crry(+/+) or wild-type erythrocytes to classical pathway complement-mediated C3 deposition in vitro PMID: 17015743
30. Results reveal multiple mechanisms of action for DAF in ameliorating systemic autoimmunity. PMID: 17392165
31. Daf1 expression is closely associated with CD4+ T cell activation and the accumulation of CD44(high)(activated/memory),CD4+ T cells in both spontaneous and induced systemic autoimmune disease. PMID: 17530719
32. These results demonstrate that DAF is an important regulator of CD8+ T cell immunity in viral infection and that it fulfills this role by acting as a complement inhibitor to prevent virus-triggered complement activation and C5aR signaling. PMID: 17709533
33. results indicate that APC-expressed DAF regulates local production/activation of C5a following cognate T cell/APC interactions PMID: 17947652
34. Novel candidate genes in T1D CD55 and Acadl were identified. PMID: 18178847
35. CD55 plays an important role in tumorigenesis of breast cancer PMID: 18676748
36. Local complement activation, regulated by donor DAF expression, exerts control over the strength of the direct alloreactive (CD8-positive) alloimmune repertoire, enhancing its pathogenicity. PMID: 18802060
37. modulation of complement activation through induction of DAF represents an important component of the cytoprotective effects of HO-1 against vascular injury PMID: 19036700
38. CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. PMID: 19297024
39. In BALB/c mice, DAF-deficient T cells mounted an immune response to local podocyte-bound heterologous IgG, resulting in clinical and pathological features of human focal and segmental glomerulosclerosis . PMID: 19349693
40. These data provide further evidence that DAF suppresses autoreactive T cell responses in experimental autoimmune encephalomyelitis. PMID: 19660813
41. The acceleration of lesion development in the absence of DAF provides confirmation of the proinflammatory and proatherosclerotic potential of complement activation in the Ldlr(-/-) mouse model. PMID: 19729477

Show More

Hide All

KEGG: mmu:13136

STRING: 10090.ENSMUSP00000027650

UniGene: Mm.101591