Recombinant Mouse Contactin-2 (Cntn2), partial

1. During development, CNTN2 absence can transiently affect the expression levels of myelin and myelin-regulating genes, and results in impaired oligodendrocyte branching and hypomyelination of fiber tracts. During de- and remyelination, Cntn2 absence did not affect oligodendrocyte survival or the extent of remyelination. PMID: 29165835
2. We further demonstrate that Cre expression initiates after birth with preservation of native Cntn2 protein. Finally, we show that Cntn23'UTR-IRES-Cre-EGFP/+ mice maintain normal cardiac mechanical and electrical function. PMID: 28358866
3. Tag1 is crucial for the olfactory circuit formation in mice. PMID: 26525675
4. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs). PMID: 25707359
5. Our results clearly demonstrate that mouse and human contactin-2 are physiological substrates for BACE1 PMID: 24405708
6. the TAG-1-mediated cell-to-cell interaction between the unpolarized multipolar cells and the pioneering axons regulates the polarization of multipolar cells partly through Lyn kinase and Rac1 PMID: 24559674
7. This study demonistrated that knockdown of the cell-surface molecule TAG-1 resulted in retraction of neocortical progenitors' basal processes. PMID: 24056697
8. These results suggest that the Tax-induced decline in p53 function, which is independent of NF-kappaB activation in the early stage, might be the first stage in the onset of ATLL. PMID: 23633516
9. two novel genes, Cntnap2 and Tag1, are implicated in the regulation of diet-induced obesity. PMID: 22752552
10. These observations identify a novel role for TAG1 in modulating the intracellular sorting of signaling receptor complexes. PMID: 22836270
11. These findings are consistent with a regulatory role for Tag-1 in axon emergence as well as migratory behavior by developing mouse cerebellar granule neurons. PMID: 21191645
12. Data show that TAG1 and F3 act antagonistically to control SHH-induced proliferation: F3 suppresses SHH-induced GNP proliferation and induces differentiation, whereas TAG1 antagonises F3. PMID: 21205796
13. Ultrastructural and behavioral analysis of Tag-1 knockout mice shows that the expression of glial TAG-1 is sufficient to restore the axonal and myelin deficits PMID: 20962216
14. These findings suggest that an age-related reduction of TAG-1 expression may predispose neurons to cell death, induced by the binding of TGFbeta2 to APP. PMID: 20184861
15. Although several aspects of the role of TAG-1 in developing sensory axons are consistent with the defects seen in Brn3a knockout mice, it is unlikely that changes in TAG-1 expression directly mediate these defects. PMID: 12598723
16. In the absence of TAG-1, axonal Caspr2 did not accumulate at juxtaparanodes, and shaker-type K+ channels in these regions were severely disrupted, in the central and peripheral nervous systems. PMID: 12975355
17. The TAX-1 upstream sequence includes elements not only sufficient to restrict expression to the nervous system, but also to recapitulate to a great extent the endogenous pattern of the TAG-1 expression in the developing CNS. PMID: 14559358
18. TAG-1 function is required for survival of the neurons of some precerebellar nuclei, while it is not required for cortical interneuron migration in vivo. PMID: 16225856
19. a TAG1-APP signalling pathway negatively modulates neurogenesis through Fe65 PMID: 18278038
20. TAG-1 modulates responses of sensory axons to diffusible guidance signals. PMID: 18550718
21. TAG-1 is an essential regulator of the structure of RGC axons and their surrounding glial cells in the optic nerve. PMID: 18650339
22. Data show that Tag-1(-/-) mice had shorter internodes in the cerebral and cerebellar white matter, and suggest that these detected molecular alterations may account for the behavioural deficits and hyperexcitability in these animals. PMID: 18760366

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KEGG: mmu:21367

STRING: 10090.ENSMUSP00000083707

UniGene: Mm.260861