Recombinant Mouse Cyclin-dependent kinase 4 inhibitor B(Cdkn2b)

Code CSB-YP005092MO
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Source Yeast
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Code CSB-EP005092MO
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Source E.coli
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Code CSB-EP005092MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005092MO
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Source Baculovirus
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Code CSB-MP005092MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Cdkn2b
Uniprot No. P55271
Alternative Names Cdkn2bCyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b
Species Mus musculus (Mouse)
Expression Region 1-130
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity).
Gene References into Functions
  1. miR-541 contributes to microcystin-LR-induced testicular toxicity by regulating the expression of p15 and promoting apoptosis. PMID: 27608041
  2. Loss of CDKN2B may not only promote cardiovascular disease through the development of atherosclerosis but may also impair TGFbeta signaling and hypoxic neovessel maturation. PMID: 26596284
  3. Radiation-induced double strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate high-grade gliomas that are commonly driven by Met amplification and activation. PMID: 24632607
  4. Data indicate that loss of cyclin-dependent kinase inhibitor p15 (p15Ink4b) collaborates with oncogene fusion protein Nup98-HoxD13 transgene in the development of predominantly myeloid neoplasms. PMID: 24449168
  5. Loss of CDKN2B promotes atherosclerosis by increasing the size and complexity of the lipid-laden necrotic core through impaired efferocytosis. PMID: 24531546
  6. Reduced CDKN2B expression and increased p53-dependent smooth muscle cell apoptosis may be one mechanism underlying the 9p21.3 association with aneurysmal disease. PMID: 23162013
  7. mRNA expression of p15 gene in mouse bone marrow cells decreases after exposure to 1,4-benzoquinone, but the CpG islands methylation status in promoter is not affected. PMID: 21619792
  8. p15Ink4b is an important modulator of cDC development and has a novel function for this tumor suppressor in the regulation of adaptive immune responses. PMID: 22461492
  9. findings indicate that in lymphoid tissue the inactivation of both p15 alleles is unlikely to be the first event in tumor development PMID: 22227036
  10. new animal model demonstrates experimentally that p15Ink4b is a tumor suppressor for myeloid leukemia, and its loss may play an active role in the establishment of preleukemic conditions PMID: 20457873
  11. is not consistently inactivated in murine myeloid cells transformed in vivo by deregulated c-Myc PMID: 12642863
  12. Ink4b is hypermethylated in murine myeloid leukemia PMID: 14681685
  13. review experiments and present examples of new models of myeloid leukemia where retroviruses have collaborated with a transgene [Cbfbeta-MYH111 from Inv(16)] and with loss of a tumor suppressor (Ink4b) mice to induce leukemia. PMID: 14757439
  14. regulation of the Ink4b promoter is apparently myeloid specific because both ICSBP and PU.1 are myeloid commitment factors. PMID: 14976051
  15. results strongly suggest that p15(Ink4b) loss must be accompanied by additional oncogenic changes for RUNX1-ETO-associated acute myeloid leukemia to develop PMID: 18037485
  16. Expression of exogenous p15AS in mouse embryonic stem cells caused p15 silencing and increased growth, through heterochromatin formation, as well as DNA methylation after differentiation of the embryonic stem cells PMID: 18185590
  17. Results indicate that Jhdm1b is an H3K36 demethylase that regulates cell proliferation and senescence through p15(Ink4b). PMID: 18836456

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Protein Families CDKN2 cyclin-dependent kinase inhibitor family
Tissue Specificity Expressed ubiquitously.
Database Links

KEGG: mmu:12579

STRING: 10090.ENSMUSP00000095595

UniGene: Mm.423094


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