Recombinant Mouse Cystatin-B (Cstb)

1. The data of this study show that CXCL13 expression is a hallmark of microglial activation in Cstb (-/-) mice and that the brain inflammation is linked to peripheral inflammatory changes, which might contribute to the disease pathology of progressive myoclonus epilepsy.. PMID: 27894304
2. CSTB has a role in chemotaxis, antigen-presentation, and in immune- and defense response-associated processes by altering JAK-STAT pathway signaling PMID: 27355630
3. Deletion of the encoding Cstb gene in Npc1-deficient mice resulted in striking deleterious effects, particularly within the cerebellum where diffuse loss of Purkinje cells was observed in young mice. This may be a consequence of damage to lysosomal membranes by reactive oxygen species (ROS), leading to the leakage of lysosomal contents that culminates in apoptosis. PMID: 26908626
4. Results suggest a role for CSTB in regulating microglial activation: data link CSTB deficiency to early activation and altered functional properties of microglia, imply presence of both enhanced and suppressed immune response-related microglial functions PMID: 25327891
5. the LPS-induced sepsis in StB KO mice is dependent on caspase-11 and mitochondrial reactive oxygen species but is not associated with the lysosomal destabilization and increased cathepsin activity in the cytosol PMID: 25288807
6. These results indicate an in vivo role for Stfb in protecting cancer cells by promoting their resistance to oxidative stress and to apoptosis induced through the lysosomal pathway. PMID: 23955077
7. Sefin B influences the expression of anti-inflammatory IL-10 in response to TLR4 agonists. PMID: 24462687
8. An increase in Cstb does not induce any spontaneous epileptic activity. PMID: 22140471
9. Pathologic events in the CSTB-deficient brain highlight the potential role of glial activation at the initial stages of progressive myoclonic epilepsy type 1. PMID: 22157618
10. this study suggesting that the Cstb-Prmt2 region is not playing a major role in locomotor and cognitive deficits found in mice model of Down syndrome. PMID: 21047530
11. Stefin B interacts with histones and cathepsin L in the nucleus PMID: 20075068
12. These findings indicate that neuronal atrophy is an important consequence of cystatin-B deficiency independent of seizure events, suggesting a physiological role for this protein in the maintenance of normal neuronal structure. PMID: 12484571
13. greater degree of neuronal damage was observed in CSTB-deficient than in WT mice after seizures of identical grade, indicating increased susceptibility to seizure-induced cell death PMID: 17188503
14. Increased cleavage of MARCKS in brain and macrophages, but not in liver and kidney extracts of stefin B-deficient mice compared to wild-type mice, was observed. PMID: 17655504
15. This study identifies a novel function for Cystatin B in defending cerebellar granule neurons from oxidative stress. PMID: 19420257

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KEGG: mmu:13014

STRING: 10090.ENSMUSP00000005185

UniGene: Mm.6095