Recombinant Mouse DNA damage-inducible transcript 4 protein (Ddit4)

1. RTP801 plays a essential role in the progression of restraint stress induced neurodegenerative disease. PMID: 29130486
2. Findings suggest that REDD1 in cacna1c heterozygous mice may influence depression-related behavior via regulation of the FoxO3a pathway. Study identified the prefrontal cortex as a key brain region in which cacna1c mechanisms through previously unidentified, novel molecular pathways contribute to depression-related behavior. PMID: 27922594
3. Diabetic wild-type mice exhibited functional deficiencies in visual acuity and contrast sensitivity, whereas diabetic REDD1-deficient mice had no visual dysfunction. The results support a role for REDD1 in diabetes-induced retinal neurodegeneration. PMID: 29074598
4. these data show that REDD1 induction regulates the exercise-mediated change in a distinct set of genes within skeletal muscle. PMID: 28899858
5. Findings suggest that REDD1 is a key mediator of cartilage homeostasis through regulation of autophagy and mitochondrial biogenesis and that REDD1 deficiency exacerbates the severity of injury-induced osteoarthritis. PMID: 28334504
6. These data suggest that loss of REDD1 augments the rate of the OV-induced increase in muscle mass by altering multiple protein balance pathways. PMID: 27465734
7. The production of superoxide anion in nockout-Rtp801 mouse lung fibroblasts (MLF) was lower than that in Rtp801 Wt cells after cigarette smoke extract treatment, and it was inhibited in Wt MLF by silencing nicotinamide adenine dinucleotide phosphate oxidase-4 (Nox4) expression with small interfering Nox4 RNA. PMID: 27556956
8. REDD1 is required for normal insulin-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1, and mTOR PMID: 27913296
9. study suggests that VDR regulates Ddit4 expression during epidermal homeostasis and the wound healing process, while elevated Ddit4 represents an early growth-arresting stress response within VDR(-/-) follicles. PMID: 27898044
10. REDD1 knockout T cells exhibit a defect in proliferation and cell survival, although markers of activation appear normal. These findings demonstrate a previously unappreciated role for REDD1 in T cell function. PMID: 26301899
11. Reactive oxygen species regulation through REDD1/TXNIP is physiological rheostat controlling stress-induced autophagy. PMID: 25916556
12. LPS induces REDD1 expression by two distinct CREB-mediated mechanisms PMID: 26296313
13. Glucocorticoids induce skin atrophy and activate REDD1 expression. PMID: 25504525
14. REDD1 expression limits the nutrient-induced stimulation of protein synthesis and activation of mTORC1 signaling during periods of feed deprivation. PMID: 25716553
15. REDD1 is necessary for hyperglycemia mediated effects on VEGF expression in the retina of diabetic mice. PMID: 25548280
16. These data suggest that epithelial mTORC1 activity plays a protective role against lung injury, and its inhibition by Rtp801 exacerbates alveolar injury caused by endotoxin. PMID: 25016184
17. The REDD1 KO mouse muscle displayed blunted mTORC1 signaling responses. PMID: 24876363
18. the results demonstrate that REDD1 acts not only as a repressor of mTORC1 but also as a constant modulator of the phosphorylation of Akt in response to growth factors and nutrients. PMID: 25056877
19. REDD1 is required for glucocorticoid-induced inhibition of protein synthesis via mTORC1 downregulation PMID: 25315696
20. Collectively, these novel data suggest that REDD1 has a more distinct role in whole body and skeletal muscle metabolism and insulin action than previously thought. PMID: 25445588
21. Data (including data from knockout mice) suggest REDD1 expression modulates mTORC1 (mechanistic target of rapamycin complex 1) signaling in skeletal muscle; downregulation of REDD1 activates mTORC1 (in refeeding and electrically induced contraction). PMID: 25159324
22. this study reports a novel pathway that increased REDD1 gene expression in macrophages. PMID: 24374096
23. significant increases in Col1a1, serine/threonine-protein kinase 1, Ctnnb1, CSRNP1, Ddit4, Cyp2e1, and Krit1 expressions and great decreases inreceptor D2, Neu1, and Dhcr7 expressions following long-term exposure to TiO2 NPs PMID: 23533084
24. P53, and its downstream target Ddit4, are novel components in the transcriptional response to food deprivation in mice. PMID: 24191950
25. The results of this study supported a role for DDIT4 as a negative regulator of myelination, as its loss both in vitro and in vivo results in hypermyelination. PMID: 24048858
26. Redd1 alone is not required for testis development or fertility in mice. PMID: 22797524
27. the induction of REDD1 gene expression was shown to require the protein kinase PERK and enhanced phosphorylation of its substrate, the alpha-subunit of eukaryotic initiation factor 2. PMID: 23000413
28. ceramide and RTP801 participate in alveolar cell apoptosis through a process of mutual up-regulation, which may result in self-amplification loops, leading to alveolar damage PMID: 23024063
29. REDD1 is a new host defense factor, and chemical activation of REDD1 expression represents a potent antiviral intervention strategy PMID: 21909097
30. REDD1-mediated suppression of mTORC1 activity exerts feedback control on p53, thereby limiting the apoptotic response and contributing to cellular survival following DNA damage. PMID: 21896779
31. elevation of Dig2/RTP801/REDD1 contributes to the induction of autophagy. PMID: 21733849
32. Redd1 induction by hypoxia is tissue dependent and hypoxia signals are relayed to Mammalian target of rapamycin complex 1 through different pathways in a tissue-specific manner. PMID: 21383064
33. Data show that loss of REDD1 induces HIF-1 stabilization and tumorigenesis through a reactive oxygen species-dependent mechanism. PMID: 20176937
34. sertraline exerts antiproliferative activity by targeting the mTOR signaling pathway in a REDD1-dependent manner PMID: 20354178
35. Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes. PMID: 19996311
36. REDD1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation [REDD1] PMID: 12453409
37. dig2 appears to have a pro-survival function, as overexpression of dig2 reduces the sensitivity of WEHI7.2 cells to dexamethasone-induced apoptosis. PMID: 12736248
38. REDD1 overexpression is sufficient to down-regulate S6 kinase phosphorylation in a TSC1/TSC2-dependent manner PMID: 15545625
39. RTP801 expression is induced by MPTP in the mouse model of Parkinson disease. PMID: 17005863
40. analysis of mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis PMID: 18070882

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KEGG: mmu:74747

STRING: 10090.ENSMUSP00000020308

UniGene: Mm.21697