DDIT4

DNA damage-inducible transcript 4 protein is a protein in humans that is encoded by DDIT4 gene. Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).

The following DDIT4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

DDIT4 Antibodies

DDIT4 Proteins

DDIT4 ELISA Kits

DDIT4 Antibodies

DDIT4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA006590GA01HU	DDIT4 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA151075	DDIT4 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA794556	DDIT4 Antibody	Human,Mouse,Rat	ELISA,IHC

DDIT4 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA763083XA01DIL	ddit4 Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

DDIT4 Proteins

DDIT4 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP600193BO CSB-EP600193BO CSB-BP600193BO CSB-MP600193BO CSB-EP600193BO-B	Recombinant Bovine DNA damage-inducible transcript 4 protein (DDIT4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DDIT4 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Code	Product Name	Source
CSB-YP747406XBF CSB-EP747406XBF CSB-BP747406XBF CSB-MP747406XBF CSB-EP747406XBF-B	Recombinant Xenopus tropicalis DNA damage-inducible transcript 4 protein (ddit4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DDIT4 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP763066XBE CSB-EP763066XBE CSB-BP763066XBE CSB-MP763066XBE CSB-EP763066XBE-B	Recombinant Xenopus laevis DNA damage-inducible transcript 4 protein (ddit4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DDIT4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP763083DIL CSB-EP763083DIL CSB-BP763083DIL CSB-MP763083DIL CSB-EP763083DIL-B	Recombinant Danio rerio DNA damage-inducible transcript 4 protein (ddit4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DDIT4 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP823776RA CSB-EP823776RA CSB-BP823776RA CSB-MP823776RA CSB-EP823776RA-B	Recombinant Rat DNA damage-inducible transcript 4 protein (Ddit4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DDIT4 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP863508MO CSB-EP863508MO CSB-BP863508MO CSB-MP863508MO CSB-EP863508MO-B	Recombinant Mouse DNA damage-inducible transcript 4 protein (Ddit4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DDIT4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP889135HU CSB-EP889135HU CSB-BP889135HU CSB-MP889135HU CSB-EP889135HU-B	Recombinant Human DNA damage-inducible transcript 4 protein (DDIT4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DDIT4 ELISA Kit

DDIT4 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL006590HU	Human DNA damage-inducible transcript 4 protein(DDIT4) ELISA kit	serum, tissue homogenates, cell lysates, urine, cerebrospinal fluid (CSF)	0.039 ng/mL

DDIT4 Background

DNA damage-inducible transcript 4 protein is a protein in humans that is encoded by the DDIT4 gene. The DDIT4 protein regulates cell growth, proliferation, and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex, and the GTPase RHEB. It plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. DDIT4 also modulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type. DDIT4 mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Besides, it is required for mTORC1-mediated defense against viral protein synthesis and virus replication.

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

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