DNA damage-inducible transcript 4 protein is a protein in humans that is encoded by DDIT4 gene. Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).

DDIT4 Antibodies

DDIT4 Antibodies for Homo sapiens (Human)

DDIT4 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

DDIT4 Proteins

DDIT4 Proteins for Bos taurus (Bovine)

DDIT4 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

DDIT4 Proteins for Xenopus laevis (African clawed frog)

DDIT4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

DDIT4 Proteins for Rattus norvegicus (Rat)

DDIT4 Proteins for Mus musculus (Mouse)

DDIT4 Proteins for Homo sapiens (Human)


DDIT4 ELISA Kit for Homo sapiens (Human)


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