Recombinant Mouse Disabled homolog 2 (Dab2)

1. miR149 was able to target Dab2 and promote the cardiac differentiation of mouse MSCs in vitro, which depended upon the Wnt/betacatenin signaling pathway. PMID: 29693140
2. Dab2 functions as a negative immune regulator of TLR4 endocytosis and signaling; it has a role in the regulatory circuit in controlling the inflammatory response of macrophages to endotoxin PMID: 27748405
3. The results suggest that Dab2 is required for the excessive calorie-induced differentiation of an adipocyte progenitor cell population that is present in juvenile but depleted in mature animals. The finding provides evidence for a limited pre-adipocyte population in juvenile mammals and the requirement of Dab2 in the regulation of Ras/MAPK signal in the commitment of the precursor cells to adipose tissues. PMID: 27779214
4. The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences. PMID: 27417122
5. The combination of Arh and Dab2 is responsible for the majority of adaptor function in LDLR endocytosis and LDLR-mediated cholesterol homeostasis. PMID: 27005486
6. Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b. PMID: 26424600
7. these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages PMID: 26927671
8. Dab2 expression is induced by hormones PMID: 25360623
9. Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis PMID: 24252604
10. Disabled-2 is required for efficient hemostasis and platelet activation by thrombin in mice. PMID: 25212232
11. Akt1 and Akt2 are involved in albumin endocytosis, and phosphorylation of Dab2 by Akt induces albumin endocytosis in proximal tubule epithelial cells. PMID: 25253241
12. Study of dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. Also, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism. PMID: 24168030
13. miR-145 regulates the migration and invasion of highly invasive prostate cancer cells through targeting DAB2 gene PMID: 24846918
14. these results indicate that p96 Dab2 plays a key role in the extra-embryonic endodermal differentiation process. PMID: 22525672
15. The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis. PMID: 22491013
16. Data show that although small RNA-mediated Dab2 knockdown had no affect on the internalization of various clathrin-dependent cargo, TGF-beta receptor recycling was abrogated. PMID: 20881059
17. TGF-beta modulates the expression of Dab2 and ILEI mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT element in the 3'UTR of Dab2 and ILEI. PMID: 20154680
18. Dab2 is pleiotropic and regulates both visceral endoderm function and lipoprotein receptor trafficking in vivo. PMID: 11927540
19. Data suggest that Dab2 is a member of a family of cargo-specific adaptor proteins, which regulate clathrin-coat assembly at the plasma membrane. PMID: 12234931
20. is essential for endodermal cell positioning and structure formation during mouse embryogenesis PMID: 12413896
21. Dab2 plays an important regulatory role during transforming growth factor beta-induced epithelial to mesenchymal transition PMID: 15734730
22. Dab2 is localized in the apical endocytic apparatus of the renal proximal tubule and that this localization requires megalin PMID: 15870384
23. These studies suggest that Dab2 p96 mediates endocytosis of megalin in the VE. In addition, rescue of embryonic viability correlates with endocytosis, suggesting that endocytosis mediated by Dab2 is important for normal development. PMID: 16263760
24. Dab2 gene was cloned and its regulatory region in the prostate was characterized. PMID: 16629596
25. This study defines a role of DAB2 in the control of neuronal plasticity and demonstrates for the first time that DAB2 is a negative regulator in nerve growth factor-mediated neurite outgrowth. PMID: 17317100
26. Dab2 is a surface positioning gene and suggest a novel mechanism of epithelial cell surface targeting. PMID: 17339320
27. Decreased DOC-2/DAB2 expression is associated with urothelial carcinoma of the bladder PMID: 17671122
28. Dab2 is dynamically expressed in various regions of the mouse central nervous system during embryonic development. PMID: 18680569
29. Dab2 plays a role in epithelial organization by suppression of c-Fos expression PMID: 19191218
30. One impaired function in Dab2-deficient regulatory T cells involves gap junction-mediated intercellular communication, whereas other mechanisms of Treg cell-mediated suppression examined appear largely intact. PMID: 19767570

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KEGG: mmu:13132

STRING: 10090.ENSMUSP00000079689

UniGene: Mm.240830