Recombinant Mouse E3 SUMO-protein ligase EGR2 (Egr2)

1. Study shows the conversion of mouse skin fibroblasts into induced Schwann cells by driving the expression of two transcription factors, Sox10 and Egr2. PMID: 28169300
2. Egr2 and Egr3 expressed in T cells cooperatively prevent humoral immune responses by supporting TGF-beta3 secretion. PMID: 27911796
3. study revealed GCN5-mediated EGR2 acetylation as a molecular mechanism that regulates iNKT development. PMID: 28723564
4. findings demonstrate a crucial role for Krox20 in arterial valve development and reveal that an excess of neural crest cells may be associated with bicuspid aortic valve. PMID: 29158447
5. these results suggested that the basal promoter activity of the mIRF-3 gene is regulated by transcription factors Egr2 and YY1 in NIH3T3 cells PMID: 26740329
6. Prss56 expression was regulated by Egr2 during mouse decidualization. PMID: 28611210
7. Egr2 and 3 are upstream regulators of effector CD4 and CD8 T cells that are essential for optimal responses with limited immunopathology. PMID: 28487311
8. Egr2 and 3 are antagonists of T-bet function in effector T cells and are important for the control of inflammatory responses of T cells. PMID: 28455436
9. We discovered that Tead1 and co-activators Yap and Taz are required for Pmp22 expression, as well as for the expression of Egr2 Tead1 directly binds Pmp22 and Egr2 enhancers early in development and Tead1 binding is induced during myelination, correlating with Pmp22 expression. The data identify Tead1 as a novel regulator of Pmp22 expression during development in concert with Sox10 and Egr2 PMID: 27288457
10. endogenous KLF4 and Krox20 are dispensable for adipogenesis in culture and for brown adipose tissue development in mice. In contrast, the master adipogenic transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) is essential. PMID: 27777310
11. Decreased expression of Krox20 in mice causes degeneration of the aortic leaflets and disorganization of the extracellular matrix, causing valvular dysfunction. PMID: 26711547
12. Mir106b regulates pro-allergic properties of dendritic cells and Th2 polarisation by targeting Egr-2 in vitro PMID: 25864617
13. let-7 miRNAs promote expression of the myelination-driving master transcription factor Krox20 PMID: 26466203
14. The data suggest that Pak2 controls thymic Natural Killer T-cell development by providing a signal that links Egr2 to induce PLZF, in part by regulating signaling lymphocyte activation molecule 6 expression. PMID: 26519537
15. demonstrate a novel function of EGR2/3 that is important for Tfh cell development and Tfh cell-mediated B cell immune responses PMID: 25979336
16. Egr-2 was upregulated by NF-kappaB activation in p50+/+ hippocampal slices. PMID: 25553923
17. EGR2 promotes peripheral naive T-cell differentiation, with delayed T-cell receptor-induced proliferation in naive T cells from Egr2 conditional knockout mice, and decreased production of cytokines in cells subjected to T-helper differentiation. PMID: 25368162
18. A direct, positive autoregulatory loop amplifies and maintains the expression of Krox20, a transcription factor governing vertebrate hindbrain segmentation. PMID: 24061538
19. The results indicated a novel role for Egr2 in repressing adipocyte lineage commitment and promoting early smooth muscle-like cell differentiation. PMID: 23751188
20. These findings support a model in which Egr2-neurons are a critical component of the respiratory chemoreflex into adulthood. PMID: 23261662
21. Egr2 acts as an intrinsic negative regulator of dendritic cell immunogenicity and can be an attractive molecular target for dendritic cell vaccine development. PMID: 23716134
22. Data indicate that epidermal growth factor receptor (EGFR) signaling stimulates the expression of transcription factor early growth response 2 (EGR2) to promote osteoprogenitor proliferation and survival. PMID: 23720781
23. Mast cell Egr2 was essential for migration of CD4(+) T cells to the inflamed lung. PMID: 23536637
24. ChIP-Seq analysis identified genes that bind Egr2 in anergic T cells, revealing 49 targets that are directly regulated by Egr2. PMID: 23548837
25. Egr-2 induced during T helper (Th)17 cell differentiation serves as a negative feedback inhibitor to control Th17-mediated inflammation. PMID: 23203924
26. results identify Egr2 as an important modulator of RANKL-induced osteoclast differentiation and provide the link between RANKL, Egr2 and Id proteins in osteoclast-lineage cells PMID: 22842221
27. Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo. PMID: 23129747
28. discovered that Egr2 and/or Egr3 directly induced expression of suppressor of cytokine signaling-1 (SOCS1) and SOCS3, inhibitors of STAT1 and STAT3, and also blocked the function of Batf, an AP-1 inhibitor, in B and T cells PMID: 23021953
29. Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent. PMID: 22049075
30. results demonstrate that Egr-2 expressed in restricted stages of lymphocyte development plays a dynamic, but similar role for the development of T, NKT and B cells PMID: 21533228
31. these findings suggest that Egr-2 plays an important nonredundant role in the pathogenesis of fibrosis. PMID: 21514423
32. Egr2 and Sox10 activity are directly involved in mediating the developmental induction of Pmp22 expression through an intronic enhancer. PMID: 21411665
33. Inactivation of Krox20/Egr2, a master regulatory gene for myelination in Schwann cells, results in transgression of the CNS/PNS boundary by astrocytes and oligodendrocytes and in myelination of nerve root axons by oligodendrocytes. Review. PMID: 21193208
34. EGR-2 is not required for CD4 T cell mediated immune responses. PMID: 20886122
35. the antimitogenic role of Krox20 in preosteoclasts is the predominant mechanism underlying the low bone mass phenotype of Krox20-deficient mice PMID: 20716776
36. data suggest that maintenance of the CNS/PNS boundary requires a Krox20 function separable from myelination control PMID: 20427655
37. survival function of Egr2 at least partly depends upon its ability to activate the cytokine-mediated survival pathway. PMID: 19877014
38. These results suggest that the dependency of the enhancer on both crest- (Sox10) and r5- (Krox20) specific factors limits its activity to the r5-derived neural crest. PMID: 12538520
39. Krox-20 protein has a role in the maturation of particular brainstem and cerebellar neurons and fluctuations in Krox-20 protein expression coincide with the development of circuitry underlying brainstem-mediated behaviors PMID: 12706208
40. that the role of Krox-20 is to amplify an earlier Krox-20-independent activation of the periaxin gene in Schwann cells PMID: 12799134
41. Ddx20 repressed Egr2-mediated transcriptional activation with significant promoter specificity PMID: 14699164
42. Data suggest that Krox-20 can control suppression of mitogenic and death responses, up-regulate the scaffold protein c-Jun NH2-terminal protein kinase (JNK)-interacting protein 1, and regulate JNK activity during Schwann cell development. PMID: 14757751
43. Egr-2 and Egr-3 transcription is enhanced by Hepatitis B virus X protein, which induces fasL gene expression PMID: 15173177
44. Sustained Egr-2 expression is necessary to induce a full anergic state through the actions of genes regulated by transcription factor Egr-2. PMID: 15585857
45. Because glucocorticoids inhibit Egr2/Krox20 expression in osteoblasts and trabecular bone formation is arrested in Egr2/Krox20-knockout mice, inhibition of Egr2/Krox20 activity likely contributes to glucocorticoid-induced osteoporosis. PMID: 15751078
46. Egr-2 and Egr-3 are involved in promoting a T cell receptor-induced negative regulatory genetic program PMID: 15834410
47. Direct induction of cholesterol/lipid biosynthetic genes by Egr2/Krox20 is a part of the myelination program regulated by the sterol regulatory element binding protein (SREBP) pathway. PMID: 15836632
48. Krox-20 regulates the period and extent of Me5 apoptosis, impacting the final number of Me5 neurons. The loss of Me5 in Krox-20-/- mice may highlight species-specific differences in the origin of these cells. PMID: 15886484
49. analysis of an Egr-2-directed transcriptional regulatory network controlled by striatal A2ARs PMID: 16046619
50. Results suggest that cooperative interactions between Egr2 and Sox10 mediate a large increase in myelin protein zero expression to the high levels found in myelinating Schwann cells. PMID: 16373334

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KEGG: mmu:13654

STRING: 10090.ENSMUSP00000041053

UniGene: Mm.290421