Recombinant Mouse Endothelial transcription factor GATA-2 (Gata2)

1. Enforced expression of Gata2 in embryonic stem cells-derived hemogenic endothelial cells enhances erythroid and megakaryocyte differentiation and inhibits macrophage differentiation. PMID: 30088690
2. Analyses of mouse models demonstrate a cell-autonomous function of GATA2 in regulating lymphatic endothelial cell (LEC) responsiveness to VEGF-C and in controlling LEC migration and sprouting in vivo. PMID: 29666442
3. endothelial SENP1-mediated SUMOylation drives graft arteriosclerosis by regulating the synergistic effect of GATA2 and NF-kappaB and consequent endothelial dysfunction. PMID: 28569748
4. GATA2 could affect the function of BM-MSCs in vivo, presumably by regulating the expression of extracellular signals. PMID: 28866324
5. Gata2 regulates a key regulatory network of gene expression for progesterone signaling at the early pregnancy stage. PMID: 27783953
6. Results show that GATA2 exerts a pro-inflammatory function in injured kidney collecting duct cells, by upregulating inflammatory cytokine gene expression thereby contributes to disease progression. PMID: 28807932
7. Gata2 mRNA levels were almost completely rescued by expression of an erythroid lineage restricted ROSA26-promotor based GATA2 transgene PMID: 23840778
8. impairment of trophoblast-specific GATA2/GATA3 function could lead to early pregnancy failure PMID: 28232602
9. both Gata2 and Gata3 are redundantly required for differentiation of the serotonergic and glutamatergic neurons of the dorsal raphe PMID: 27789623
10. Dynamically and epigenetically coordinated GATA2/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation. PMID: 28334937
11. High GATA2 expression is associated with leukemia. PMID: 27443289
12. results suggest that GATA2 plays an important role in cell-fate specification toward the myeloid vs T-lymphocyte lineage by regulating lineage-specific transcription factors in DC progenitors, thereby contributing to DC differentiation. PMID: 27259979
13. These results demonstrated that an enforced expression of Gata2 in late HECs of differentiated ESCs efficiently promotes megakaryopoiesis followed by platelet production. This study provides valuable information for ex vivo platelet production from human pluripotent stem cells in future. PMID: 27131743
14. we identified important roles for the GATA-2 C-ZnF in bone marrow hematopoiesis via control of c-Kit expression and HSC/HSPC survival. PMID: 26660446
15. Gata2 as a crucial rheostat of mesenchymal stem cell fate to control osteoblast and adipocyte lineage development. PMID: 26812161
16. LSD1 mediates erythroid differentiation, via epigenetic modification of the GATA-2 locus. PMID: 26124638
17. Results provide new insights into the selective roles of Gata2 within the genetic model of V2 interneurons development and in particular on the hierarchy between V2-transcription factors PMID: 25369423
18. Conditional Gata2 deletion in mice revealed that GATA2 is required for both development and maintenance of lymphovenous and lymphatic vessel valves. PMID: 26214525
19. These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 expression. PMID: 25848090
20. these results indicate that GATA2 maintains cellular identity in a subpopulation of mast cells, whereas it plays a fundamental role as a positive regulator of mast cell-specific genes throughout development of this cell lineage. PMID: 25855601
21. GATA2 plays an important role in regulating the differentiation potential of BM-MSC and contributes to hematopoietic supporting capacity. PMID: 25150255
22. Our study reveals that the STAT5-GATA2 pathway is critical for basophil and mast cell differentiation and maintenance. PMID: 25801432
23. Data indicate that peroxisome-proliferator activated receptor gamma (PPARgamma) promoter harbors leptin response region that includes a GATA binding protein-2 (GATA-2) binding site. PMID: 25305367
24. we demonstrate that GATA2 acts downstream of IRF8 in regulating basophil and mast cell development PMID: 25398936
25. GATA2 is epigenetically repressed in human and mouse lung tumors and its further inhibition is not a valid therapeutic strategy for KRAS mutant lung cancer. PMID: 24807155
26. GATA2 regulates the Aqp2 gene expression in collecting duct cells and contributes to the maintenance of the body water homeostasis PMID: 24636993
27. established a Gata2 repression/reactivation assay, which revealed unique +9.5 site activity to mediate GATA factor-dependent chromatin structural transitions PMID: 24616499
28. GATA2 and Lmo2 cooperatively regulate VEGF-induced angiogenesis and lymphangiogenesis via NRP2. PMID: 23892628
29. Results of this study show that LPS induction of il-1beta gene expression in macrophages is mediated by GATA-2 via activation of TLR4, MyD88, and MAPKs. PMID: 23940812
30. a Gata2 cis-element (+9.5) is required for hematopoietic stem cell generation in the mammalian embryo PMID: 24297994
31. GATA2 is essential for hematopoietic stem cell survival PMID: 24297996
32. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster PMID: 23322776
33. The composite E-box/GATA-motif element disrupted in a human immunodeficiency is essential for establishment of the murine hematopoietic stem/progenitor cell compartment in the fetal liver and for essential vascular processes. PMID: 22996659
34. The vascular-endothelial enhancer regulates GATA-2 expression in fetal liver & adult BM HSCs. GATA-2 function is required for proper lymphatic vascular development during embryogenesis. PMID: 22996665
35. results suggest a role for Gata2 as a selector gene of both GABAergic neuron neurotransmitter and prosomere subtype identities in the developing diencephalon PMID: 22991444
36. Study reports that GATA2 protein is expressed in the uterine luminal and glandular epithelium pre-implantation, spatio-temporally co-localizing with that of the progesterone receptor. PMID: 22476030
37. Injury-induced repression of miR-200b turned on wound angiogenesis. In mice with diabetes mellitus,excessive tumor necrosis factor-alpha induced miR-200b blunting proangiogenic functions of GATA2 and VEGFR2. PMID: 22499991
38. In a Kras-driven NSCLC mouse model, Gata2 loss dramatically reduced tumor development. Furthermore, Gata2 deletion in established Kras mutant tumors induced striking regression PMID: 22541434
39. PPARgamma promotes osteoclast progenitors by activating GATA2 transcription PMID: 21947280
40. expression of Gata2, Mash1, and Foxa2 synergizes to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells PMID: 21472823
41. Data show that Gata2 is required from E14.5-E15.5 onward for vestibular morphogenesis, as without Gata2 the semicircular ducts fail to grow to their normal size and surrounding mesenchymal cells are not removed to generate the perilymphatic space. PMID: 20652952
42. Cis element regulation of the critical hematopoietic factor Gata2, which is expressed in early precursors and repressed as GATA-1 levels rise during terminal differentiation, was analyzed. PMID: 20838598
43. GATA2 and Sp1 play crucial roles in expression of the c-kit gene in mast cells PMID: 20833840
44. The 2H and 5H domains have the independent ability to activate Gata2 gene expression in the midbrain superior colliculus, whereas the distal-5H domain is additionally capable of activating Gata2 transcription in the inferior colliculus. PMID: 19371385
45. Gata-2 transcripts accumulate rapidly in the fetal ovary from 11.5 days post coitum (dpc) onwards, but are not detected in the fetal testis throughout the period studied (10.5-15.5 dpc). Ovarian expression of Gata-2 ceases by 15.5 dpc PMID: 11804789
46. transcription factor GATA-2 plays a significant role in the expression of the skeletal muscle L-type Ca(2+) channel alpha(1S). PMID: 11956331
47. role in the development and differentiation of hematopoietic progenitors; conditional activation of a GATA-2/ER chimera produced opposite effects to those observed with conditional GATA-2 expression PMID: 12065419
48. multiple domains of Pit-1 are required for full synergy with GATA-2 and sequences between the two binding sites contribute to co-occupancy with both factors on the proximal TSH beta promoter PMID: 12385825
49. regulation of cytokine-dependent growth of hematopoietic cells through accumulation of p21(WAF1) and p27(Kip1) proteins PMID: 12393444
50. that GATA-2 is expressed in the precursor of hematopoietic cells and works as a gatekeeper to preserve their immaturity. A reduction of GATA-2 expression or activity is required for the differentiation of precursors to hematopoietic cells. PMID: 12689939

Show More

Hide All

KEGG: mmu:14461

STRING: 10090.ENSMUSP00000015197

UniGene: Mm.491156