Recombinant Mouse Excitatory amino acid transporter 3 (Slc1a1), partial

1. Here is reported a model of Slc1a1 loss based on an excisable STOP cassette that yields successful ablation of EAAT3 expression and function. EAAT3 loss prevents expected increases in (i) locomotor activity, (ii) stereotypy, and (iii) immediate early gene induction in the dorsal striatum following amphetamine administration. PMID: 28507136
2. Morphine increased EAAT3 expression in the plasma membrane of medial prefrontal cortex, nucleus accumbens and ventral tegmental area but did not affect EAAT3 expression in the hippocampus. Results also suggest that EAAT3 delays the extinction of morphine-induced conditioned place preference (CPP). EAAT activation may prevent the formation of morphine-induced CPP. PMID: 28049029
3. partial loss of the Slc1a1 gene in mice causes haploinsufficiency associated with behavioral, histological and biochemical changes that reflect an altered redox state and may promote the expression of behavioral features and inflammatory states consistent with those observed in schizophrenia. PMID: 28886095
4. this paper shows increased EAAC1 protein expression in lysates from livers of NOD mice compared with B6 mice PMID: 27649685
5. These findings suggest that cysteine uptake by EAAC1 is important for neuronal antioxidant function under ischemic conditions. PMID: 25350110
6. these studies indicate that absence of EAAC1 results in either a decrease in pilocarpine-induced seizures that is not detectable by behavioral criteria PMID: 24334055
7. EAAT3 is upstream of PKA in a pathway to regulate GluR1 trafficking. PMID: 24412196
8. EAAT3/EAAC1 expression is altered in murine models of human neurodegenerative diseases. (Review) PMID: 24162932
9. These results suggest that the isoflurane preconditioning-induced acute phase of neuroprotection involves EAAT3. PMID: 23827345
10. These findings indicate that regulation of heart rate, a vital sign, is one of the EAAT biological functions. PMID: 23361868
11. Study implicates EAAC1-dependent cysteine uptake as an endogenous source of enhancing antioxidant function and zinc homeostasis in neurons in the ischemic brain. PMID: 22575539
12. This study showed that these relatively small amounts of EAAC1 protein are widely distributed in somata and dendrites of all hippocampal neurons. PMID: 22539860
13. These findings identify a mechanism whereby Nrf2 activation can coordinate astrocyte glutathione release with neuronal glutathione synthesis through transcriptional upregulation of neuronal EAAT3 expression. PMID: 21593323
14. EAAT3 is important in limiting ischemic brain injury after focal brain ischemia PMID: 21139629
15. GLAST, GLT1 and EAAC1 are needed to clear neurotransmitter from the synapse after intense acoustic stimulation, and to protect the cochlea from exposure to glutamate present in the extracellular space PMID: 20220082
16. Rab11 dysfunction slows trafficking of EAAC1 to the cell surface and impairs cysteine uptake, thereby leading to deficient synthesis of glutathione. PMID: 20357106
17. Our findings suggest that the use of IL-1 for enhancing the function of glutamate transporters (EAAC1, but not GLAST) may be useful for neuroprotection in retinal degenerative disorders including normal tension glaucoma. PMID: 19766171
18. data provide evidence for an active role of the neuronal glutamate transporter EAAC1 in the generation of anoxic depolarizations PMID: 11973429
19. EAAC2 transcript has a cluster of transcriptional start sites not overlapping with the transcriptional start sites of EAAC1; results indicate that EAAC2 is transcribed from an independent promoter but not an alternative splicing event [EAAC2] PMID: 12296385
20. lack of EAAC1 may disturb normal osmolyte balance in the proximal epididymal lumen and compromise sperm maturation and sperm volume regulatory mechanisms PMID: 12399522
21. Mediates cysteine uptake in cultured cortical neurons PMID: 12614333
22. effects of mutations R39A, R61A, and Y98A on glutamate uptake and glutamate-induced currents and selectivity between NO3- and Cl- of the conductance mode PMID: 15471567
23. EAAC1 is the primary route for neuronal cysteine uptake and EAAC1 deficiency leads to impaired neuronal glutathione metabolism PMID: 16311588
24. Decreased EAAC1 is associated with Niemann-Pick disease, type C PMID: 16429462
25. Functions in rescuing motor neurons from nerve injury. PMID: 16858406
26. FGF2 deficiency leads to decreased expression of presynaptic markers of integrity for glutamatergic fibers in the striatum, namely the membrane excitatory amino acid transporter 3 (EAAT3) and the vesicular glutamate transporter 1 (VGLUT1 PMID: 17161387
27. glutamate transporters are necessary both to prevent excitotoxic retinal damage and to synthesize glutathione PMID: 17607354
28. caveolin-1 contributes to the trafficking of EAAC1 on and off the plasma membrane PMID: 17715130
29. Expression of GTRAP3-18 delays the ER exit of EAAC1, as well as other members of the excitatory amino acid transporter family. PMID: 18167356
30. Data show that EAAC1 of EL mice at 10 weeks of age decreased more than those of DDY. PMID: 18621028
31. Arl6ip1 is a novel addicsin-associated partner that promotes EAAC1-mediated glutamate transport activity by decreasing the number of addicsin molecules available for interaction with EAAC1 PMID: 18684713
32. stimulation of EAAC1-mediated glutamate transport by thapsigargin is dependent on entry of calcium via the NSCC-1 subtype of store operated calcium channel and is mediated by protein kinase C PMID: 19133225
33. The findings suggest that protein kinase C (PKC) is involved in regulation of surface trafficking of GLT1 and EAAC1 and that PKC stimulated increase in surface location of GLT1 and EAAC1 in glutamatergic cerebellar granule cells. PMID: 19364521
34. EAAC1 buffers glutamate release during synaptic events and prolongs the time course of its clearance by astrocytes. PMID: 19923291

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KEGG: mmu:20510

STRING: 10090.ENSMUSP00000025875

UniGene: Mm.246670