Recombinant Mouse Forkhead box protein C2 (Foxc2)

1. Foxc2 influences alveolar epithelial cell differentiation during lung development PMID: 28675425
2. FOXC1 and FOXC2 are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases PMID: 27214551
3. Compound, NC-specific Foxc1; Foxc2 homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2, and its downstream effector Dkk2, which antagonizes canonical Wnt signaling. PMID: 28253399
4. Foxc1 and Foxc2 maintain glomerular podocyte integrity by regulating the gene expression. Foxc2 plays a more critical role than Foxc1. PMID: 28223138
5. Foxc1 and Foxc2 have a role in kidney and axial skeleton development. PMID: 27193493
6. Our results are consistent with previous reports of Foxc2 expression during early embryogenesis and the Foxc2(CreERT2) mouse provides a tool to investigate spatiotemporal roles of Foxc2 and contributions of Foxc2(+) expressing cells during mouse embryogenesis. PMID: 27783871
7. Conditional knockout of Foxc2 gene in kidney has been generated using conditional alleles of single-exon gene by double-selection system. PMID: 26542959
8. Data show that segregation of Foxc2 and NFATc1 transcription factor is closely associated with the highly polarized expression of connexins Cx37, Cx43, and Cx47. PMID: 26953188
9. deletion of Foxc1 and Foxc2 specifically in Pax3-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb PMID: 26839363
10. Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation PMID: 26299482
11. Foxc2 enhances proliferation of preadipocytes and inhibits apoptosis of preadipocytes by activating the Akt/mTORC1 and ERK/mTORC1 signaling pathways PMID: 26113535
12. In murine models, inducible deletion of Foxc2 within the lymphatic vasculature led to cell-cell junction defects, regression of valves, and focal vascular lumen collapse, which triggered generalized lymphatic vascular dysfunction and lethality. PMID: 26389677
13. Foxc2 and Cx37 are elements in a common molecular pathway directing lymphangiogenesis. PMID: 26079578
14. Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis. PMID: 23645207
15. Results indicate that Foxc2 plays an important role in osteoblastogenesis by promoting osteoblast proliferation, survival and differentiation through up-regulation of integrin beta1 in response to stimuli which induce bone formation. PMID: 21640215
16. Dysmorphogenesis of lymph nodes in Foxc2 haploinsufficient mice PMID: 21614587
17. these findings demonstrate that haplodeficiency of Foxc2 results in impaired formation of tumor blood vessels as well as reduced tumor growth and thereby provide evidence that Foxc2 is critical for tumor development and angiogenesis. PMID: 20060810
18. Foxc2 may have regulatory functions independent of its nuclear transcriptional activity. PMID: 19935708
19. FoxC2 and Ang2 are novel targets of Prox1 in mouse embryonic-stem-cell-derived endothelial cells. PMID: 19825936
20. Shows reciprocal inhibition between Pax3 and Foxc2 in the mouse embryo; using both genetic approaches and manipulation of external signals in somite explants, demonstrated that the Pax3:Foxc2 ratio modulates myogenic versus vascular cell fates. PMID: 20059958
21. insulin and TNF alpha regulate the expression of Foxc2 via a PI3K- and ERK 1/2-dependent pathway in 3T3-L1 adipocytes PMID: 11923482
22. Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP. PMID: 11943768
23. FoxC2 blocks adipogenesis by inhibiting the capacity of PPARgamma to promote the expression of a subset of adipogenic genes PMID: 15277530
24. Foxc2 is expressed in developing lymphatic vessels PMID: 15465483
25. Results demonstrate that Foxc1 and 2 transcription factors are novel regulators of arterial cell specification upstream of Notch signaling and lymphatic sprouting during embryonic development. PMID: 16678147
26. Fox2c is required for the development of the second heart field where the outflow tract, right ventricle, and part of the atrium and inflow tract are derived from a second cell lineage encompassing the secondary heart field. PMID: 16839542
27. Foxc2 plays a key role in metastasis and is associated with aggressive basal-like breast tumors. PMID: 17537911
28. These results provide novel evidence that Foxc transcription factors are important regulators of the chemotactic motility of endothelial cells through the induction of CXCR4 expression. PMID: 18187037
29. Foxc2 directly induces Itgb3 expression and regulates angiogenesis by Itgb3-mediated endothelial cell adhesion and migration. PMID: 18579532
30. the FOXC2-Ang-2 signaling system is crucial for controlling adipose vascular function, which is part of an adaptation to increased adipose tissue metabolism PMID: 18621714
31. FOXC2 and NFATc1 are potential targets for therapeutic intervention and damage may be a major cause of lymphatic dysfunction. PMID: 19398761
32. Foxc2 stimulated osteoblast differentiation of mesenchymal cells and preosteoblasts. PMID: 19540201

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KEGG: mmu:14234

STRING: 10090.ENSMUSP00000055290

UniGene: Mm.14092