Recombinant Mouse Forkhead box protein J1 (Foxj1)

1. Non stem- and progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated. PMID: 29379049
2. Our findings provide clues regarding the role of FOXJ1 as a tumor inducer in bladder cancer and an enhancer in glycolysis. Targeting FOXJ1 could be a potential therapeutic strategy in bladder cancer. PMID: 29129693
3. genome-wide expression profiles of undifferentiated E14.5 vs. abundantly ciliated E18.5 micro-dissected airway epithelia as well as Foxj1(+) vs. Foxj1-deficient foetal (E16.5) lungs of the mouse were compared using microarray hybridisation. PMID: 27914912
4. p73 drives multiciliogenesis, both through transcriptional activation of a master ciliogenesis transcription factor FoxJ1 and through regulation of multiple genes central to ciliogenesis. PMID: 26988441
5. MYB has an early, crucial and conserved role in multiciliogenesis, and it promotes a novel S-like phase in which centriole amplification occurs uncoupled from DNA synthesis, and then drives later steps of multiciliogenesis through induction of Foxj1. PMID: 24048590
6. noto and foxj1 have roles in node formation, nodal ciliogenesis and cilia positioning PMID: 22357932
7. we found that Ank3 expression is controlled by Foxj1, a transcriptional regulator of multicilia formation. PMID: 21745638
8. For the first time, our study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods. PMID: 21697387
9. Data show that floor plate identity and ciliogenesis are unaffected in mouse embryos lacking Foxj1 and we provide evidence that additional transcription factors expressed in the floor plate share overlapping functions with Foxj1. PMID: 21098568
10. foxj1 functions in late-stage ciliogenesis to regulate programs promoting basal body docking and axoneme formation in cells previously committed to the ciliated cell phenotype. PMID: 12818891
11. role in the regulation of T cell activation and autoreactivity; Foxj1 likely modulates inflammatory reactions and prevents autoimmunity by antagonizing proinflammatory transcriptional activities PMID: 14963332
12. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. PMID: 14996907
13. Asymmetric gene expression during left-right axis patterning occurs in Foxj1 knockout mice. PMID: 15504371
14. Foxj1 restrains B cell activation and the maturation of humoral responses in vivo. PMID: 16002694
15. These results indicate that a random signal of laterality (Foxj1) is dominant over the reversal signal of laterality (Inv). PMID: 16325766
16. Murine cytomegalovirus influences Foxj1 expression, ciliogenesis, and mucus plugging in mice with allergic airway disease. PMID: 18258850
17. FoxJ1 playes role in in oro-facial morphogenesis. PMID: 18723525
18. foxj1 is expressed specifically in the embryonic node throughout the developmental window critical for left-right patterning. PMID: 19165828
19. Foxj1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. PMID: 19906869
20. Foxj1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia. PMID: 17971504

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KEGG: mmu:15223

STRING: 10090.ENSMUSP00000038351

UniGene: Mm.378938