Recombinant Mouse Forkhead box protein L1 (Foxl1)

Code CSB-YP727367MO
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP727367MO
MSDS
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Source E.coli
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Code CSB-EP727367MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP727367MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP727367MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Foxl1
Uniprot No.
Alternative Names
Foxl1; Fkh6; Fkhl11Forkhead box protein L1; Forkhead-related protein FKHL11; Transcription factor FKH-6
Species
Mus musculus (Mouse)
Expression Region
1-336
Target Protein Sequence
MSHLFSPPLA ALAASPLLYV YSPERPGLPL AFAPAAALAG PGRVEPPQKP PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNECFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPAAG SPEAKRTRVE PPESEVGCDV GSPDLATALP TRAPDRSQSP AVGTARPALL PWPGPEPRDP DADLTVQGAG AVASGQLQRP AHHLGSPLCP APSGSPKGSK SKSFSIDSIL AVRPTPASGA EAPGIPKPVP GALGSSLLAA SSGLAPPFNA SLVFDAHVQG GFSQLGIPFL SYFPLQVPEA TVLRFH
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.
Gene References into Functions
  1. SALL4 associated with the NuRD co-repressor and repressed expression of the tumor suppressor genes Foxl1 and Dusp4. PMID: 28867346
  2. Foxl1(+) hepatic progenitor cells and/or their descendants are required for the development of cholangiocytes and hepatocytes in liver injury models. PMID: 25286440
  3. Foxl1 might be involved in cellular responses of gut-associated lymphoid tissues dependent upon the Lymphotoxins/Lymphotoxin beta-receptor axis. PMID: 12648490
  4. link between a mesenchymal factor, Foxl1, and the regulation of a specific epithelial transport process in intestinal epithelium PMID: 15155178
  5. Mesenchymal Modifier of Min, plays a key role in gastrointestinal tumorigenesis. PMID: 15650110
  6. Foxl1 is a bona fide marker of the facultative progenitor cell in the mouse liver. PMID: 19105206
  7. promotes liver repair after bile-duct-ligation-induced liver injury through activation of the canonical wnt/beta-catenin pathway PMID: 19841618

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Subcellular Location
Nucleus.
Database Links
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