Recombinant Mouse Fos-related antigen 2 (Fosl2)

Code CSB-YP008793MO
MSDS
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Source Yeast
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Code CSB-EP008793MO
MSDS
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Source E.coli
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Code CSB-EP008793MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP008793MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP008793MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Fosl2; Fra-2; Fra2Fos-related antigen 2; FRA-2
Species
Mus musculus (Mouse)
Expression Region
1-326
Target Protein Sequence
MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT INAITTSQDL QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP GVIKTIGTTV GRRRRDEQLS PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEELE EEKSGLQKEI AELQKEKEKL EFMLVAHGPV CKISPEERRS PPTSGLQSLR GTGSAVGPVV VKQEPPEEDS PSSSAGMDKT QRSVIKPISI AGGGFYGEEP LHTPIVVTST PAITPGTSNL VFTYPNVLEQ ESPSSPSESC SKAHRRSSSS GDQSSDSLNS PTLLAL
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
Gene References into Functions
  1. Fra-2 overexpression might impair myofibroblast functions crucial for secondary septation PMID: 28818870
  2. Data show that Fos-Related Antigen-2 (Fra-2) is a key upstream regulator of forkhead box O1 (Foxo1) and interferon regulatory factor 4 (Irf4) expression and influences proliferation and differentiation of B cells at multiple stages. PMID: 28566276
  3. Deletion of Fra-2 leads to increased PPARgamma2 expression and adipocyte differentiation as well as increased adipocyte apoptosis through upregulation of hypoxia-inducible factors. PMID: 24464219
  4. Cytokine-mediated Fra-2 expression and stabilization is linked to regulation of myogenic progenitor cells. PMID: 23807221
  5. AP-1 composed with JunD and Fra2 protein plays a primary role in enhancing the transcription level of the CD11c gene in dendritic cells PMID: 22990073
  6. FOSL2 is a critical regulator of leptin expression in adipocytes PMID: 22326952
  7. Identify Fra-2 as an O(2)-sensitive transcriptional regulator of inducible TGFbeta expression and position Fra-2 as an important player in reoxygenation-induced myocardial fibrosis. PMID: 20427335
  8. Since transgenic overexpression of Fra-2 causes not only fibrosis but also vascular disease, Fra-2 might be an interesting novel candidate for molecular-targeted therapies for systemic sclerosis. PMID: 20039427
  9. Fra2 is a novel transcription factor important for skeletogenesis by affecting chondrocyte differentiation PMID: 15509771
  10. MEKK1 regulates Fra-2 protein stability by inducing Fra-2 ubiquitination and degradation. PMID: 15558021
  11. NFATc1 negatively regulates osteoblst differentiation by regulating fra-2 PMID: 16340132
  12. These data identify junD proto-oncogene (JunD) and Fos-related antigen 2 (Fra-2) as the activator protein-1 (AP-1) factors responsible for the RANKL-induced upregulation of the mouse Tcirg1 gene expression. PMID: 17419679
  13. Fos-related protein Fra-2 controls osteoclast survival and size PMID: 18548006
  14. Fra-2 is necessary for regulation of normal invariant natural killer (iNK)T cell development and function; loss of Fra-2 causes a 2.5-fold increase in thymic iNKT cells. PMID: 19620306
  15. Fra-2 transcripion factor induces progressive peripheral vasculopathy in mice that resembles human systemic sclerosis. PMID: 19933934

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Subcellular Location
Nucleus.
Protein Families
BZIP family, Fos subfamily
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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