Recombinant Mouse G0/G1 switch protein 2 (G0s2)

Product Details

Purity

≥85% (SDS-PAGE)

Target Names

G0s2

Uniprot No.

Q61585

Alternative Names

G0s2G0/G1 switch protein 2; G0S2-like protein

Species

Mus musculus (Mouse)

Expression Region

1-103

Target Protein Sequence

MESVQELIPL AKEMMAQKPR GKLVKLYVLG SVLALFGVVL GLVETVCSPF TAASRLRDQE AAVVELREAC EQQSLHKQAL LAGGKAQEAT LCSRALSLRQ HAS

Protein Length

full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

Gene References into Functions

ER+ breast cancer cells with restored G0S2 expression had a relative increased sensitivity to tamoxifen PMID: 28910567
G0S2 protein but not mRNA levels were reduced in the adipose tissue of ATGL-deficient mice, corroborating the involvement of ATGL in the stabilization of G0S2 PMID: 27248498
G0S2 silencing mediates MYC-induced oncogenesis in other malignancies PMID: 26837760
G0S2 expression in naive CD8(+) T cells decreased immediately after T-cell receptor activation downstream of various signal transduction pathways. G0S2 inhibits energy production by oxidative phosphorylation to fine-tune proliferation in homeostasis. PMID: 25666096
findings do not rule out the possibility that G0S2 may be playing a role in other forms of leukemia, but clearly show that the commonly used Emu-Myc transgenic is not the correct model to conduct studies on G0s2 PMID: 26654706
G0s2 is a physiological regulator of adiposity and energy metabolism and is a potential target in the treatment of obesity and insulin resistance. PMID: 25381555
Proteasomal degradation of PPAR-gamma and the reduction of g0s2 content are permissive for prolonged TNF-alpha induced lipolysis. PMID: 24993166
G0s2 has an important role in adipogenesis and accumulation of triacylglycerol. PMID: 24583640
Roles for G0S2 were found in lactation, energy balance, and thermogenesis. This study provides a basis for tumor suppressive effects of G0S2 by regulating lipolysis. PMID: 24556704
fat-specific G0S2 overexpression uncouples adiposity from insulin sensitivity and overall metabolic health through inhibiting adipose lipolysis and decreasing circulating fatty acids. PMID: 24302733
Data indicate that downregulation of G0S2 in adipose tissue could represent one of the underlying causes leading to increased lipolysis in the insulin-resistant state. PMID: 22891293
a novel model of HSC quiescence in which elevated G0S2 expression can sequester nucleolin in the cytosol, precluding its pro-proliferation functions in the nucleolus PMID: 22693613
minimal fragment of ATGL could still be activated and inhibited by CGI-58 and G0S2, respectively PMID: 22039468
Lipolysis is differently regulated between perigonadal and mesenteric adipocytes, and these depot-specific differences might be explained by altered regulation of G0S2 and/or perilipin. PMID: 21989031
overexpression of G0S2 diminishes the rate of lipolysis in both adipocytes and adipose tissue explants PMID: 20197052
A novel putative target gene of PPARalpha, G0S2 (G0/G1 switch gene 2) was identified and characterized. PMID: 16086669

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Subcellular Location

Mitochondrion.

Database Links

KEGG: mmu:14373

STRING: 10090.ENSMUSP00000009777

UniGene: Mm.439721

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Recombinant Mouse G0/G1 switch protein 2 (G0s2)

Product Details

Customer Reviews and Q&A

Target Background

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