Recombinant Mouse Geminin (Gmnn)

1. Geminin plays important roles in pre-meiotic DNA replication and subsequent spermatogenesis. PMID: 28690291
2. Lack of Geminin promotes adult neural stem cell commitment toward the oligodendrocytic lineage at the expense of the neuronal differentiation without altering their ability to self-renew. PMID: 28557659
3. These results provide proof-of-principle that preventing geminin function could prevent malignancy in tumors derived from pluripotent cells by selectively eliminating the progenitor cells with little harm to normal cells. PMID: 27821018
4. cell penetrating (CP) Geminin is imported into the nucleus after incorporation and also the incorporated CP-Geminin directly interacted with Cdt1 or Brahma/Brg1 as the same manner as Geminin PMID: 27195810
5. Study shows that ablation of Geminin induces massive rereplication as a result of unrestrained Cdt1 activity in embryonic stem cells, whereas it has no such effect in embryonic fibroblasts in which alternative regulation of Cdt1 activity is intact. PMID: 28296014
6. Maternal geminin does not regulate oogenesis and oocyte meiotic maturation, but it does control accurate DNA replication and timely cleavage of fertilized eggs. PMID: 26764091
7. Regulation of gene expression by geminin occurs only after pluripotent cells differentiate into cells in which geminin is not essential for viability. PMID: 26140583
8. Geminin is an important regulator of self-renewal and survival of enteric nervous system progenitor cells. PMID: 26658318
9. geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system. PMID: 25516969
10. these data demonstrate a requirement for Geminin for neural tube patterning and neuronal differentiation during mammalian neurulation in vivo. PMID: 24995796
11. geminin is required for Sox2 expression, and thus for the maintenance of totipotency, pluripotency and the early neural lineage. PMID: 24069236
12. geminin acts both like a component of the FGF4 signal transduction pathway that governs trophoblast proliferation and differentiation, and geminin is required to maintain endocycles. PMID: 24412371
13. Data indicate that geminin supported neural differentiation. PMID: 23249188
14. Geminin dysregulation may be restored by derepressed Hoxb4 and Hoxa9 in Scmh1-deficient mice. PMID: 23207902
15. Geminin is required during preimplantation development. Geminin knockdown inhibited the epithelial to mesenchymal transition via its ability to affect Wnt signaling and E-cadherin expression. PMID: 22335560
16. Geminin promotes the neuronal precursor cell state by modulating both the epigenetic status and expression of genes encoding neurogenesis-promoting factors. PMID: 22949506
17. Geminin is absolutely required for mitotic proliferation of spermatogonia but does not regulate their differentiation. PMID: 22898305
18. Geminin regulates cortical progenitor proliferation and differentiation PMID: 21681860
19. Geminin has been shown to coordinate proliferation and differentiation by regulating cell cycle progression, chromatin organization, and transcription in the nervous system. (Review) PMID: 21740351
20. Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development. PMID: 21543332
21. Geminin is largely dispensable for most of embryonic and adult mammalian neurogenesis. PMID: 21408022
22. Data suggest that transduced Hoxb4 down-regulates Geminin protein probably by constituting the E3 ubiquitin ligase for Geminin to provide hematopoietic stem and progenitor cells with proliferation potential. PMID: 21098278
23. role for Geminin as a cell intrinsic regulator of neural fate acquisition that promotes expression of neural genes by regulating chromatin accessibility and histone acetylation. PMID: 21300881
24. CD34(+) Gmnn(-/-) leukocyte precursors displayed DNA overreplication and formed extremely small granulocyte and monocyte colonies in methylcellulose. PMID: 21041951
25. Data indicate that T cells deficient in Geminin show a reduced ability to repopulate lymphopenic hosts in vivo. PMID: 20107189
26. role in inhibiting Cdt1-MCM6 interactions as well as a novel intrinsic Cdt1 DNA binding activity PMID: 12192004
27. murine geminin associates transiently with members of the Hox-repressing polycomb complex, with the chromatin of Hox regulatory DNA elements and with Hox proteins PMID: 14973489
28. geminin does not have a role in Cdk-phosphorylation/negative regulation of Cdt1 PMID: 14993212
29. Data show that geminin is regulated transcriptionally by the retinoblastoma tumor suppressor (RB)/E2F pathway PMID: 15084580
30. crystal structure of the mouse geminin-Cdt1 complex using tGeminin (residues 79-157, truncated geminin) and tCdt1 (residues 172-368, truncated Cdt1) PMID: 15286659
31. Geminin is also down-regulated in wild-type blastocysts during S and gap-like phases by proteasome-mediated degradation, suggesting that loss of geminin is part of the mechanism regulating endoreduplication. PMID: 16847348
32. geminin is essential for cooperative progression of the cell cycle through S phase to M phase during the preimplantation stage of development PMID: 17054725
33. Geminin is present from S to M phase in the cell cycle PMID: 17533120
34. These results suggested that, at least in vitro, oleic acid-containing cell membranes of the lipid bilayer inhibit Cdt1-geminin complex formation by binding to Cdt1 and thereby liberating Cdt1 from inhibition by geminin. PMID: 18288374
35. PcG complex 1, involving Rae28 and Cdt1, supports the activity of hematopoietic stem cells by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin PMID: 18650381
36. Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy PMID: 18693245
37. TIPT2 synergizes with geminin and TBP in the activation of TATA box-containing promoters. PMID: 19515240
38. Geminin, which interacts with HOXD13 as well, blocks HOXD13-mediated assembly of pre-replication complex proteins and inhibits HOXD13-induced DNA replication. PMID: 19703996

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KEGG: mmu:57441

STRING: 10090.ENSMUSP00000006898

UniGene: Mm.12239