Product Details

Purity

>85% (SDS-PAGE)

Target Names

Grik2

Uniprot No.

P39087

Alternative Names

Grik2; Glur6; Glutamate receptor ionotropic; kainate 2; GluK2; Glutamate receptor 6; GluR-6; GluR6; Glutamate receptor beta-2; GluR beta-2

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2.; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons.

Gene References into Functions

GluK2-mediated increase in KCC2 recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA). PMID: 28235805
Loss of parkin function in primary cultured neurons causes GluK2 protein to accumulate in the plasma membrane. PMID: 25316086
Interictal and ictal discharges are minimized in mice lacking the GluK2 subunit. PMID: 25043179
14-3-3 proteins are an important regulator of GluK2a-containing KARs and may contribute to the slow decay kinetics of native KAR-EPSCs. PMID: 23861400
This study demonistrated that grik2 gene expression in mouse dorsal raphe nucleus PMID: 22534482
The results show that NETO2 is a kainate receptor subunit with significant effects on glutamate signaling mechanisms in brain. PMID: 19217376
The facilitatory effects of kainate on mossy fiber synaptic transmission and plasticity are mediated by GLU(K6)-containing kainate receptors. PMID: 15537878
The related kinases SGK2 and SGK3 similarly stimulate GluR6, but are less effective than SGK1. PMID: 15774535
Thus, GluR6a and GluR6b bring in close proximity two separate subsets of interacting proteins that contribute to the fine regulation of KAR trafficking and function. PMID: 16102538
Gbeta5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells. PMID: 18001285
The involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania PMID: 18332879
Our results are indicative of either down-regulation of kainate receptors or modulation of their functional characteristics in weaver (Girk2-wv mutant) granule cells. PMID: 19263192
To our knowledge, the present work is the first report of a GluK receptor as the target of chronic treatment with mood-stabilizing drugs. This effect was both drug-specific and receptor subtype-specific. PMID: 19596362

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK2 subfamily

Tissue Specificity

Most abundant in the cerebellum and the hypothalamus. Expressed in a proportion of dorsal root ganglion (DRG) neurons (13.6%); predominantly small diameter DRG neurons (75%) with the remainder expressed in medium diameter DRG neurons.

Database Links

STRING: 10090.ENSMUSP00000101124

UniGene: Mm.185993

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Recombinant Mouse Glutamate receptor, ionotropic kainate 2 (Grik2), partial

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