Recombinant Mouse Glutamine synthetase (Glul)

1. genetic deletion of Glul in endothelial cells impairs vessel sprouting during vascular development, whereas pharmacological blockade of glutamine synthetase suppresses angiogenesis in ocular and inflammatory skin disease while only minimally affecting healthy adult quiescent endothelial cells PMID: 30158707
2. The data identify GS activity as mediator of the proangiogenic, immunosuppressive, and pro-metastatic function of M2-like macrophages and highlight the possibility of targeting this enzyme in the treatment of cancer metastasis. PMID: 28813676
3. Our study highlights a new role of GS in modulating immune response in microglia, providing insights into the pathogenic mechanisms associated with inflammation and new strategies of therapeutic intervention PMID: 27758118
4. We conclude that 1) GS-mediated ammonia recycling in the PT contributes to both basal and acidosis-stimulated ammonia metabolism and 2) adaptive changes in other proteins involved in ammonia metabolism occur in response to PT-GS-KO and cause an underestimation of the role of PT GS expression. PMID: 27009341
5. Diabetes induces TXNIP expressions at mRNA levels, but shows the opposite effect on GS. PMID: 27131835
6. Results indicate that astrocyte glutamine synthase may be the predominant contributor to the pathogenic mechanisms of D-gal-induced brain aging in mice. PMID: 25128847
7. Hepatic deletion of GS triggered systemic hyperammonemia, which was associated with cerebral oxidative stress as indicated by increased levels of oxidized RNA and enhanced protein Tyr nitration. PMID: 25870278
8. modulation of intracellular glutamine levels by GS expression represents an endogenous mechanism through which mature adipocytes control the inflammatory response PMID: 25451225
9. GABABR2 has a role as a regulator of glutamine synthetase stability PMID: 25172509
10. the capacity for ammonia disposal correlated inversely with the expression of glutamine synthetase in muscle PMID: 25074987
11. Glutamine synthetase in astrocytes from entorhinal cortex of the triple transgenic animal model of Alzheimer's disease is not affected by pathological disease progression. PMID: 23990215
12. In a transgenic mouse model of Alzheimer disease, found decrease in number of GS-positive astrocytes in prefrontal cortex from early to middle ages when compared with control animals. PMID: 24059854
13. Renal glutamine synthetase is expressed in type A intercalated cells, non-A, non-B intercalated cells, and distal convoluted tubule cells, but not in principal cells, type B intercalated cells, or connecting segment cells. PMID: 23804452
14. Methionine sulfoximine target glutamine synthetase is required for the early steps of the cytokine response to endotoxins, and that its pharmacological inhibition may be exploited to treat inflammation. PMID: 21745296
15. BDNF can up-regulate GLAST and GS and increase glutamate uptake during hypoxia, and these functions may underlie its neuroprotective effects. PMID: 21448920
16. Glutamine synthetase deficiency in murine astrocytes results in neonatal death. PMID: 20140959
17. Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification PMID: 20064933
18. Reduction of GS in TGF-beta1-on-mice results from apoptosis of GS-positive hepatocytes rather than downregulation of GS expression PMID: 15246211
19. aspartate aminotransferase and glutamine synthetase have roles in glucocorticoid activation in mouse Schwann cells PMID: 16182522
20. There was a >100-fold difference in GS mRNA, protein, and enzyme-activity levels among organs, whereas there was only a 20-fold difference in the GS protein:mRNA ratio, suggesting extensive transcriptional and posttranscriptional regulation. PMID: 16609703
21. oestradiol induced expression of GS suggests a significant role for glial cells in hormonal modulation of glutamatergic neurotransmission important to female reproductive behaviours, neuroendocrine physiology and cognitive functions PMID: 16879168
22. In myocytes and hepatomas, but not in adipocytes, glutamine acts to moderate glutamine synthetase induction by glucocorticoids. PMID: 17197094
23. In H4Flox liver, glutamine synthetase (GS), ornithine aminotransferase (OAT) and thyroid hormone-receptor beta1 (TRbeta1) were exclusively expressed in pericentral hepatocytes. PMID: 17256722
24. Our results indicate that individuals with reduced glutamine synthetase activity may have reduced FS seizure thresholds. Genetic association studies will be required to test this hypothesis. PMID: 19170755

Show More

Hide All

KEGG: mmu:14645

STRING: 10090.ENSMUSP00000083375

UniGene: Mm.210745