Recombinant Mouse H-2 class I histocompatibility antigen, K-B alpha chain (H2-K1), partial

1. Major histocompatibility class I molecules H2-Kb and H2-Db proteins regulate sculpting of local cortical circuits and in their absence, the excess connectivity can function as a substrate for cortical plasticity throughout life. PMID: 25316337
2. H-2Kb in an unfolded form to a post-endoplasmic reticulum compartment from where they can cycle back to the endoplasmic reticulum. PMID: 26714929
3. tissue-specific h-2K(d) transgenic mice may be valuable tools for determining the mode of induction of CD8(+) T-cell responses. PMID: 23142461
4. Analysis of CD8-positive T lymphocytes responsive to an H-2Kb-restricted immunodominant peptide displays T cell-homing patterns that support surveillance of both upper- and lower respiratory tract tissues by clonally related cells. PMID: 21690324
5. Adult mice exposed to a noninherited maternal antigen accepts permanently H2-Kb-positive heart allografts despite the presence of normal levels of anti-K(b) T cell receptor transgenic T cells. PMID: 21178009
6. Major histocompatibility class Ib-restricted CD8-positive T cells, in addition to H2-M3-restricted T cells, contribute to antilisterial immunity and may contribute to immune responses against other intracellular bacteria. PMID: 21098224
7. The interaction of SHIP, 2B4 activating receptor, and the major histocompatibility complex influence the regulation of the natural killer (NK) cell receptor repertoire, cytolytic function, and interferon-gamma production. PMID: 20363967
8. Data imply that a cognate linkage between TLR3 and MHC class I is required for efficient CTL priming to HSV-1. PMID: 20124105
9. Endoplasmic reticulum aminopeptidase (ERAAP)-deficiency changes the antigen processing mechanism and causes a marked increase in the length of peptides normally presented by the histocompatibility class I-peptide binding groove. PMID: 20173027
10. Data provide biological confirmation that the chromosome 6 QTL provided MCMV control independent of H-2(k) via NK cells. PMID: 19820922
11. showed that a large disulfide-bonded complex was present in the mouse cells that included ERp57, tapasin, and K(d). PMID: 19687800
12. Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus. PMID: 11943852
13. intramembrane mechanism by which unassembled H2Kb molecules are retained in the endoplasmic reticulum of fibroblasts PMID: 12006653
14. The H2-K(b) gene belongs to target genes of the NF-IL6 (C/EBPbeta) in the course of the cellular response to TNF-alpha. Some consequences of this are discussed in a general framework of inducible expression of the H2-K(b) gene. PMID: 12184911
15. linked mhc polymorphism-driven diversification of the cytotoxic T lymphocyte repertoire to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense PMID: 12459592
16. crystal structure complexed with an HBV-core nonapeptide PMID: 15272181
17. signaling through the mouse NK inhibitory receptor Ly49C requires the presence of H-2Kb and this signaling is prevented when H-2Kb is ablated by pulsing with a peptide that can bind to it with high affinity PMID: 16148097
18. two H-2K(k)-peptide complexes provide insights into the mechanisms through which MHC polymorphism outside primary peptide pockets influences the conformation of the bound peptides and have implications for TCR recognition PMID: 16148128
19. Linkage analysis performed in F(2) backcross ([BALB/c x C3H/HeN] x BALB/c) mice carrying the H2(k) region confirmed the presence of a susceptibility locus within the H2 region on proximal chromosome 17. PMID: 16148132
20. analysis of K(d)-restricted antigen presentation and recognition events PMID: 16473882
21. These results demonstrate that Ly49Q efficiently binds H-2K(b) ligand. PMID: 17240452
22. Study presents the 2.35 A structure of the 2C TCR complexed with its foreign ligand H-2L(d)-QL9; surprisingly, TCR utilizes a different strategy to engage the foreign pMHC in comparison to the manner in which it recognizes a self ligand H-2K(b)-dEV8. PMID: 17418792
23. Naive polyclonal class Ib-restricted CD8-positive T cells have the ability to homeostatically expand in the periphery in a largely class Ib-dependent manner. PMID: 18292501
24. the mHpa398 and mHpa519 peptides are novel H-2K(b)-restricted CTL epitopes capable of inducing heparanase-specific CTLs in vitro and in vivo PMID: 18316618
25. an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain. PMID: 18453559
26. data suggest that APLP2 modulates the stability and endocytosis of K(d) molecules PMID: 18641335
27. Ethanol-elicited reduction in proteasome activity contributes to the suppression of SIINFEKL-H2Kb presentation on the surface of liver cells. PMID: 19195028
28. These physiological and behavioral phenotypes in K(b)D(b-/-) mice reveal a surprising role for classical MHCI molecules in synaptic plasticity and motor learning. PMID: 19346486
29. the MHC class I D locus prompts expansion and activation of Ly49G2(+) NK cells that are needed in H-2(k) MCMV resistance. PMID: 19454713
30. comparison of the consequences of MHC overexpression in muscle at different ages;a markedly more severe disease phenotype in young mice, with rapid onset of muscle weakness and pathology PMID: 19700752
31. H2-Kb and H2-Db ligands, signaling via neuronal class I histocompatibility antigen receptors, may enable activity-dependent remodeling of brain circuits during developmental critical periods. PMID: 19945389

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KEGG: mmu:14972

STRING: 10090.ENSMUSP00000025181

UniGene: Mm.422886