Recombinant Mouse Heart- and neural crest derivatives-expressed protein 2 (Hand2)

1. Analysis reveals that altered Hand2 expression in the maxillary arch results in altered homeobox transcription factor regulation in the mandibular and maxillary processes and a transformation of the upper jaw into the lower jaw. The results of the present study also suggest that nested Hand2 expression in the mandibular arch is necessary for palatogenesis. PMID: 27329940
2. HAND2 directly regulates the molecular cascades initiating atrioventricular canal cardiac valve development. PMID: 28538179
3. Results demonstrate a change in Hand2 target genes during maturation of sympathetic neurons. Whereas Hand2 controls genes regulating noradrenergic differentiation during development, Hand2 seems to be involved in the regulation of genes controlling neurotransmission in adult sympathetic neurons. PMID: 26818017
4. transcription of a Hand2-associated long non-coding RNA, which we named upperhand (Uph), is required to maintain the super-enhancer signature and elongation of RNA polymerase II through the Hand2 enhancer locus PMID: 27783597
5. endocardial Hand2 is an integral downstream component of a Notch endocardium-to-myocardium signaling pathway and a direct transcriptional regulator of Neuregulin1. PMID: 25497097
6. analysis uncovers the transcriptional circuits that function in establishing distinct mesenchymal compartments downstream of HAND2 and upstream of SHH signaling PMID: 25453830
7. Hand2 loss-of-function dramatically reduces expression of Dopamine Beta Hydroxylase (Dbh), a gene encoding a crucial catecholaminergic biosynthetic enzyme PMID: 24565998
8. in vivo inhibition of miR-25 by a specific antagomir evoked spontaneous cardiac dysfunction and sensitized the murine myocardium to heart failure in a Hand2-dependent manner PMID: 24161931
9. overdosage of Hand2 is a major cause for the limb and heart defects phenotypes. PMID: 23449628
10. Hand2 and NFATC physically interact on the DEGS1 promoter in the hypoxic mouse heart. PMID: 23672204
11. Twist1, along with Hand2, is essential for the proximodistal patterning and development of the mandible and ossification. PMID: 22411303
12. Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches. PMID: 22595513
13. Results suggest that Hand2 is essential for neurogenesis, neurotransmitter specification and neural network patterning in the developing enteric nervous system. PMID: 21989918
14. Data suggest Hand2 plays an important role in decidualization (especially in response to PGE2) and in obtaining proper progesterone-dependent uterine sensitization required for implantation. PMID: 21527398
15. We now show that enteric neurogenesis is a quantitative function of Hand2 expression in mice. PMID: 21669203
16. the interaction of bHLH transcription factor Hand2 with E2a is required for transcription of Phox2b, which is essential for autonomic nervous system neuron development. PMID: 21453680
17. These data suggest that cytokines can inhibit norepinephrine transporter expression through downregulation of Hand2 or Gata3 in cultured sympathetic neurons, but axotomy in adult animals selectively suppresses Hand2 expression. PMID: 21241805
18. Hand2 is essential for survival of second heart field progenitors and that the graded loss of Hand2 function in this cardiac progenitor pool can cause a spectrum of congenital heart malformation. PMID: 21185281
19. Hand2 and Twist1, show altered expression in both Hand1 null and hypomorphic backgrounds and intercrossing the Hand1 hypomorphic mice onto the Hand2 systemic null background exacerbates the cardiac and lateral mesoderm phenotypes. PMID: 20737509
20. findings show Hand2 is a critical regulator of the uterine stromal-epithelial communication that directs proper steroid regulation conducive for the establishment of pregnancy PMID: 21330545
21. Hand2 is regulated by miR-133a in addition to miR-1 PMID: 20974915
22. The preaxial polydactyly phenotype observed in Etv mutants is suppressed by a mutation in Hand2, which, with ETV and Twist1, attains a precise balance to establish anterior-posterior patterning of the limb. PMID: 20826535
23. Chromatin immunoprecipitation shows that Hand2-containing chromatin complexes are bound to the far upstream cis-regulatory region (ZRS), which is specifically required for Shh expression in the limb bud. PMID: 20386744
24. The data support a model of Hand2 regulating endochondral ossification via two steps: (1) determination of the site of chondrogenesis by outlining the region of the future cartilage template and (2) regulation of the rate of chondrocyte maturation. PMID: 19932774
25. results indicated that Nrf2 protects against the development of pulmonary fibrosis by regulating the cellular redox level and lung Th1/Th2 balance. PMID: 20298567
26. Targeted deletion of Hand2 in the neural crest results in misalignment of the aortic arch arteries and outflow tract, contributing to development of double outlet right ventricle and ventricular septal defects. PMID: 20144608
27. function as a transcriptional activator by binding to E-boxes as a heterodimer PMID: 11812799
28. misexpression of dHAND induces ectopic digits in the developing limb bud; findings suggest that dHAND may act via novel transcriptional mechanisms mediated by protein-protein interactions independent of direct DNA binding PMID: 12070084
29. HAND2 is an upstream transcriptional regulator of ANP expression PMID: 12392994
30. The expression of this protein was studied in the possible morphogenesis of the lower incisor tooth. PMID: 12397375
31. We show that dHAND is first expressed in postmigratory cephalic neural crest cells within the pharyngeal arches PMID: 12729557
32. Akt-mediated signaling may regulate dHAND transcriptional activity through the modulation of its DNA binding activity during embryogenesis PMID: 15291810
33. dHAND/E-protein (E2A, ME2, and ALF1) heterodimers have distinct DNA binding specificities PMID: 15351717
34. loss of HAND2 in the pharyngeal arch mesenchyme leads to apoptosis in an Apaf-1-dependent fashion PMID: 15649468
35. Hand2, a transcription factor that promotes ventricular cardiomyocyte expansion, is a target of microRNAs, and these genes control the balance between differentiation and proliferation during cardiogenesis PMID: 15951802
36. Hand 2 functions to promote autonomic nervous system development as part of a larger transcriptional complex PMID: 16145670
37. The absence of Hand2 expression in the interventricular boundary region inhibits expansion and trabeculation in this area, contributing to the proper formation of the interventricular septum . PMID: 16530167
38. Hand2 is necessafry for terminal differentiation of enteric neurons from crest-derived precursors. PMID: 17507395
39. data suggest that the major role of Hand2 during SNS development is to permit sympathetic neurons to acquire a catecholaminergic phenotype PMID: 17531968
40. the importance of Hand2 transcription factor in the transcriptional circuitry of craniofacial and tooth development PMID: 17764670
41. Hand2 is a multifunctional DNA binding protein affecting differentiation and cell type-specific gene expression in neural crest-derived noradrenergic sympathetic ganglion neurons. PMID: 18501887
42. Expression of HAND2 is maintained in sympathetic neurons throughout fetal and postnatal development when these neurons depend on nerve growth factor for survival. PMID: 18724272
43. Hand2 regulates tissue growth and development in vivo through DNA binding-dependent and -independent mechanisms PMID: 19211672
44. Mouse embryos homozygous for Hand2 gene deletion showed decreased sympathetic neuron number and TH expression was strongly reduced in the residual neuron population PMID: 19254708
45. Hand2 is an intrinsic regulator in the epithelium and is required for palate development. PMID: 19341725
46. these results suggested that Hand2 bound to the promoter of nanog, a gene required for embryonic stem cells self-renewal, and suppressed nanog expression after Hand2 induction. PMID: 19785992

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KEGG: mmu:15111

STRING: 10090.ENSMUSP00000044983

UniGene: Mm.430844