Recombinant Mouse Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs)

1. Findings find that Hrs is indispensable for the autophagic clearance of neurodegeneration-related proteins and for the survival of hippocampal neurons in mammals. In particular, the work provides the novel insight that the loss of Hrs results in insufficient autophagic clearance and enhanced ER stress, thereby triggering JNK activation and subsequent apoptotic and necroptotic neuronal cell death. PMID: 27112194
2. HGS expression in the nervous system is developmentally regulated.HGS is required for motor neuron function. PMID: 26115514
3. Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility. PMID: 26078721
4. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. PMID: 25296754
5. A new mechanism to modify BMP signaling by Hgs during early mouse development. PMID: 21953618
6. Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins PMID: 15640163
7. Nedd4-2 induces binding of ENaC to Hrs, which mediates the sorting decision between ENaC degradation and recycling. PMID: 20675381
8. Peptidergic versus nonpeptidergic specification depends on a balance between HGF-Met signaling and Runx1 extinction/maintenance in primary nociceptive neurons. PMID: 20844136
9. These data indicated that Hrs is involved in the regulation of antigen-presentation activity through the exosome secretion. PMID: 20673754
10. Src phosphorylates Hrs in vitro & in vivo. Hrs is phosphorylated in Src-, Yes- & Fyn-negative cells. 10-20% is phosphorylated after EGF stimulation at multiple tyrosines in different parts of Hrs by several kinases downstream of the EGF receptor. PMID: 12180964
11. Hrs, Eps15, and STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway. PMID: 12551915
12. the TSG101 interaction with HRS is a crucial step in endocytic down-regulation of mitogenic signaling and this interaction may have a role in linking the functions of early and late endosomes PMID: 12802020
13. Our results suggest that GEF-1 may induce MDCK and C3H10T1/2 cells to trans-differentiate into myoblast-like cells. PMID: 15158678
14. the Hrs hexamer interacts with the membrane and acts as a "master molecule" that presents multiple sites for protein binding PMID: 16615908
15. In structure-function studies of Cbl and EGFR mutants, the level of Hrs phosphorylation and rapidity of apparent Hrs dephosphorylation correlated directly with EGFR degradation. PMID: 17101784
16. The restoration of Hrs expression increased cell proliferation and anchorage-independent growth in a mouse embryonic fibroblast line established from a Hrs knockout mouse. PMID: 17545595
17. These data suggest that Hrs plays an important role in neural cell survival in vivo and provide an animal model for neurodegenerative diseases that are known to be commonly affected by the generation of proteinaceous aggregates. PMID: 19008375

Show More

Hide All

KEGG: mmu:15239

STRING: 10090.ENSMUSP00000026900

UniGene: Mm.7919