Recombinant Mouse Histone acetyltransferase KAT2A (Kat2a), partial

1. These findings established a link between GCN5 and the FGF signaling pathway and highlighted specific GCN5-MYC partnerships in gene regulation during early differentiation. PMID: 29249668
2. Sumoylation of RORgammaT regulates TH17 differentiation and thymocyte development via histone acetyltransferase KAT2A, which stabilizes the binding of SRC1 to enhance RORgammaT transcription factor activity. PMID: 30451821
3. Gcn5 regulates Hoxc11 gene expression through mediating site-specific H3K9 acetylation in Akt1-/- MEFs. PMID: 28541373
4. recovering GCN5 expression in vivo by lentiviral expression vector significantly attenuated the loss of angiogenesis in ovariectomized mouse femurs PMID: 28642327
5. study reveals previously unknown physiological functions for Gcn5 and a molecular mechanism underlying these functions in regulating T cell immunity; Gcn5 may be an important new target for autoimmune disease therapy PMID: 28424240
6. Together, our experiments identify a novel nonhistone substrate of GCN5, highlight an essential role for both GCN5 and RA signaling in early diencephalic development, and elucidate a novel molecular regulatory mechanism for RA signaling that is specific to the developing forebrain. PMID: 28154153
7. Methionine was the only essential amino acid that rapidly induced PGC-1alpha acetylation through activating the GCN5 acetyltransferase. PMID: 27022023
8. these results may point to the GCN5-NF-kappaB pathway as a novel potential molecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis. PMID: 26420353
9. In addition to reducing atrogene expression, surprisingly inhibiting NF-kappaB with IkappaBalpha-SR or by GCN5 knockdown in these muscles also enhanced AKT and mechanistic target of rapamycin (mTOR) activities, which also contributed to the reduction in atrophy. PMID: 26515065
10. Gcn5 and PCAF repress IFN-beta production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 in the cytoplasm. PMID: 25269644
11. GCN5 and HDAC1 are the crucial enzymes that regulating epigenetic reprogramming; we observed dynamic changes in the expression levels of GCN5 and HDAC1 during embryo development PMID: 23888963
12. Our data establish Kat2a as a novel and essential regulator of hippocampal memory consolidation. PMID: 25024434
13. Study reveals that Gcn5/PCAF facilitate adipogenesis through regulation of PPARgamma expression and regulate brown adipogenesis by influencing Prdm16 expression. PMID: 25071153
14. In conclusion, these data establish Kat2a as a novel and essential regulator of hippocampal memory consolidation. PMID: 25024434
15. Sirt6 interacts with and modifies GCN5, enhancing GCN5's activity. PMID: 23142079
16. Data support a model in which p23 and GCN5 regulate diverse multistep pathways by controlling the longevity of protein-DNA complexes. PMID: 23022381
17. Data have defined an important role for GCN5 in NSC and provided evidence that GCN5 is an important Myc transcriptional cofactor in vivo. PMID: 22745758
18. In the absence of PU.1, there is decreased association of Gcn5 and p300/CBP associated factor and increased association of histone deacetylases at the interleukin (Il)9 locus in T helper (Th)9 cells. PMID: 22904310
19. GCN5 as a new negative regulator of transactivation by E1A and suggest that its KAT activity is required for optimal virus replication. PMID: 22623781
20. findings demonstrate that loss of Gcn5 functions can contribute to the time of onset and severity of SCA7 phenotypes, and suggest that non-transcriptional functions of SAGA may play a role in neurodegeneration in this disease PMID: 22002997
21. SIRT1 deacetylase activity is not required for exercise-induced deacetylation of PGC-1alpha or mitochondrial biogenesis in skeletal muscle; changes in GCN5 acetyltransferase activity may be an important regulator of PGC-1alpha activity after exercise PMID: 21757760
22. Results showed that in -vitro culture environments could inhibit GCN5 expression and decrease the expression of HDAC1 in mouse preimplantation embryos, which might affect the correct embryonic gene expression. PMID: 16416968
23. Gcn5 has important, histone acetyltransferase-independent functions in early development PMID: 17325035
24. Gcn5 may be required to maintain pluripotent states PMID: 17440986
25. Results indicate that normal levels of Gcn5 expression are critical for neural tube closure in mice and predict that mutations in Gcn5 may be associated with increased risk of neural tube defects in humans. PMID: 18330926
26. p300 acts as a critical coactivator of FXR induction of SHP by acetylating histones at the promoter and FXR itself PMID: 18842595

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KEGG: mmu:14534

STRING: 10090.ENSMUSP00000099407

UniGene: Mm.218837