KAT2A, or lysine acetyltransferase 2A, is also known as GCN5, hGCN5, GCN5L2, and PCAF-b. It is a histone acetyltransferase (HAT) that is widely expressed in human cells, and its main role is to act as a transcriptional activator to promote transcriptional activation of genes through acetylation of histones.
KAT2A also has other functions, such as acting as a deterrent for NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA. In addition, KAT2A is involved in a variety of biological processes, including long-term memory, positive regulation of macromolecular metabolic processes, and regulatory T-cell differentiation, etc.
Abnormal expression of KAT2A has been associated with a variety of diseases, such as cancer and metabolic disorders, and is one of the most important targets for drug development.
Validated Data
IHC image of CSB-PA002657 diluted at 1:66 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-PA002657 diluted at 1:66 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Immunofluorescence staining of Hela cell with CSB-PA002657 at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
The following KAT2A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
KAT2A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011987GA01HU | KAT2A Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA002657 | KAT2A Antibody | Human | IF, IHC, ELISA |
CSB-PA821706LA01HU | KAT2A Antibody | Human | ELISA, IHC |
CSB-PA821706LD01HU | KAT2A Antibody, Biotin conjugated | Human | ELISA |
KAT2A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP821706HU CSB-EP821706HU CSB-BP821706HU CSB-MP821706HU CSB-EP821706HU-B |
Recombinant Human Histone acetyltransferase KAT2A (KAT2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KAT2A Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP884898MO CSB-EP884898MO CSB-BP884898MO CSB-MP884898MO CSB-EP884898MO-B |
Recombinant Mouse Histone acetyltransferase KAT2A (Kat2a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |