Recombinant Mouse Histone acetyltransferase KAT2B (Kat2b), partial

1. histone H3K9 acetyltransferase PCAF plays a critical role in osteogenic differentiation of mesenchymal stem cells. PMID: 27300495
2. These results uncover p300 as a direct target of mTORC1 and suggest that the mTORC1-p300 pathway plays a pivotal role in cell metabolism by coordinately controlling cell anabolism and catabolism PMID: 29033323
3. The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development. PMID: 29016683
4. This study demonstrated that pcaf increase in skeletal muscle in muscle atrophy. PMID: 26372908
5. Treatment with a pan-acetylase inhibitor, anacardic acid, reduced the binding affinity of p300 and PCAF to the NKX2.5, beta-MHC, Cx43 promoters and attenuated H3K9 hyperacetylation. PMID: 25797917
6. Gcn5 and PCAF repress IFN-beta production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 in the cytoplasm. PMID: 25269644
7. PCAF acetylates two lysine residues K328 and K450 in PGC-1alpha. PCAF in the obese mouse liver greatly represses gluconeogenic enzyme activation and glucose production and improves glucose homeostasis and insulin sensitivity. PMID: 25497092
8. Study reveals that Gcn5/PCAF facilitate adipogenesis through regulation of PPARgamma expression and regulate brown adipogenesis by influencing Prdm16 expression. PMID: 25071153
9. KLF10, functions as a toggle to integrate antagonistic signals regulating FOXP3 via Sin3-HDAC/PCAF pathway and, thus, immune activation. PMID: 24944246
10. PCAF is necessary for axonal regeneration and also promotes regeneration after spinal cord injury. PMID: 24686445
11. These data unveil a p53/PCAF/Gli1 circuitry centered on PCAF that limits Gli1-enhanced mitogenic and prosurvival response. PMID: 24013724
12. PCAF is an important regulator for promoting osteoblast differentiation via acetylation modification of Runx2. PMID: 23468178
13. CSB and PCAF play cooperative roles to establish the active state of rRNA genes by histone acetylation PMID: 23667505
14. Depletion of KAT2B or WDR5 decreased gluconeogenic gene expression. PMID: 24051374
15. PCAF acts as master switch in the inflammatory processes required for effective arteriogenesis. PMID: 23788761
16. Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. PMID: 22896699
17. Within the context of fear extinction, p300/CBP-associated factor functions as a transcriptional coactivator. PMID: 22933779
18. p300 and PCAF cooperate in the control of microRNA 200c/141 transcription and epithelial characteristics PMID: 22384255
19. downregulation of PCAF by TNF-alpha provides negative feedback regulation to inflammatory reactions in liver epithelial cells; upregulated microRNAs in TNF-alpha-treated cells, miR-181a/b (miR-181a and miR-181b) suppressed translation of PCAF mRNA PMID: 22219331
20. One function of histone acetyltransferase p300 within the prefrontal cortex is to constrain synaptic plasticity, since it is required for the formation of fear extinction memory. PMID: 21593332
21. low SIK2 activity was associated with increased p300 HAT activity, ChREBP hyperacetylation, and hepatic steatosis PMID: 21084751
22. p53, TA-p73, and p300 binding and Foxo3 expression decrease during liver regeneration, and this suggests a critical growth control mechanism mediated by these transcription factors in vivo. PMID: 20564353
23. Data demonstrate that ERRalpha interacts with and is acetylated by p300 coactivator associated factor (PCAF) in vitro and in mouse liver. PMID: 20484414
24. We conclude that PCAF regulates the expression of proteins involved in Abeta generation and degradation, thus rendering PCAF KO insensitive to amyloid toxicity. PMID: 20219649
25. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but is constitutively elevated in metabolic disease states PMID: 19883617
26. These results identified the KLF8 activation domain located between residues 101-260 where the well-conserved Q118 and Q248 are essential for recruiting p300 and PCAF to activate target gene transcription. PMID: 20107328
27. Data demonstrate that Foxp3 is acetylated, and this can be reciprocally regulated by the histone acetyltransferase p300 and the histone deacetylase SIRT1. PMID: 19996091
28. Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma PMID: 11884404
29. Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. PMID: 11940575
30. co-activation of crystallin gene expression PMID: 11943779
31. acetylation of AML1 through p300 is a critical manner of posttranslational modification and identify a novel mechanism for regulating the function of AML1 PMID: 14752096
32. the stability of PCAF is regulated by MDM2 by its ubiquitination and degradation PMID: 14769800
33. P/CAF and p300 have roles in acetylation-induced stabilization of E2F1 PMID: 15123636
34. established that pCAF and p300 carry out sequential and functionally distinct events on a promoter leading to transcriptional activation in a MyoD-dependent in vitro transcription system PMID: 15289617
35. Mdm2 (murine double minute 2), in the presence of active H-Ras or N-Ras, induces CBP/p300 degradation in NIH 3T3 cells PMID: 16704373
36. p300 acetyltransferase activity is essential for maintaining self-tolerance of B lymphocytes. PMID: 17513743
37. These observations demonstrate that PCAF histone acetylase is involved lifelong in the chromatin remodeling necessary for memory formation and response to stress. PMID: 17805310
38. HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity. PMID: 18250163
39. Contributes to Hox homeodomain gene regulation and is required for normal anteroposterior patterning of the mouse skeleton. PMID: 18430026
40. Data show that p300/CBP-associated factor could increase the beta-catenin transcriptional activity, induce its nuclear translocation, and up-regulate its protein level by inhibiting its ubiquitination and improving its stability. PMID: 18987336
41. P/CAF deacetylation by HDAC3 and in a minor degree by HDAC1, HDAC2, or HDAC4 leads to cytoplasmic accumulation of P/CAF. PMID: 19015268

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KEGG: mmu:18519

STRING: 10090.ENSMUSP00000000724

UniGene: Mm.255025