Recombinant Mouse Histone-lysine N-methyltransferase MLL (Mll), partial

1. Kmt2a is also important in memory formation PMID: 28723559
2. Collectively, these data indicated that ATR or ATM inhibition represent potential therapeutic strategies for the treatment of AML, especially MLL-driven leukemias. PMID: 27625305
3. Epigenomic profiling indicates an abnormal H3K79me2 pattern on MLL-fusion targeted genes, but the molecular mechanism underlying this epigenetic dependency is not well understood. PMID: 27151433
4. NUP98-HOXA9 interacts with MLL via the NUP98 second FG repeat domain. In the absence of MLL (in knockout mice), NUP98-HOXA9-induced cell immortalization and leukemogenesis are severely inhibited. MLL is important for the recruitment of NUP98-HOXA9 to the HOXA locus and for NUP98-HOXA9-induced HOXA gene expression. MLL is crucial for NUP98-HOXA9 leukemia initiation. PMID: 28210005
5. These results define an important role for MLL1 in regulating macrophage-mediated inflammation in wound repair and identify a potential target for the treatment of chronic inflammation in diabetic wounds. PMID: 28663191
6. these results implicate an important role for MLL1-dependent epigenetic regulation of macrophage antimicrobial functions PMID: 28733487
7. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors. PMID: 27485686
8. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1. PMID: 27801610
9. HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development. PMID: 26725110
10. Set1 role in cellular reprogramming and its interactions with Dpy30,Myc,Sox2 and Ash2l reprogramming factors PMID: 26691508
11. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model. PMID: 26657054
12. We have demonstrated that the Mll1 gene is critical to Th1 differentiation in humans and mice PMID: 26059830
13. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation. PMID: 25267403
14. Data indicate that Meis homeobox 1 (MEIS1) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF)is a key downstream mediator of Meis1. PMID: 25740828
15. mature prefrontal neurons critically depend on maintenance of Mll1-regulated methylation at a subset of genes with an essential role in cognition and emotion. PMID: 25834037
16. Recruited MOF activity, and not the intrinsic HMT activity of MLL1, is central for the maintenance of HSC target genes. In addition, this work reveals a role for SIRT1 in opposing MLL1 function. PMID: 24813891
17. Mouse and human cell/xenograft systems have been generated and used to understand how MLL-R (MLL1-1 rearrangement) alleles affect diverse pathways to result in a highly penetrant, drug-resistant leukemia. Review. PMID: 25264566
18. MLL1 functions as a coactivator of HSF1 in response to HSP90 inhibition PMID: 24831003
19. Results indicate that intra-molecular complex formation is a crucial maturation step whereas proteolytic cleavage is dispensable for mixed lineage leukemia (MLL)-dependent gene activation and proliferation in vivo. PMID: 24040009
20. The loss of Mll1 has a distinct impact on cell proliferation, based on differentiation state of the hematopoietic stem/progenitor. PMID: 23974107
21. Mll2, one of the six Set1/Trithorax-type H3K4 methyltransferases in mammals, is required for trimethylation of bivalent promoters in mouse embryonic stem cells, whereas Mll1 is redundant. PMID: 24423662
22. a double knock-in of Mll(PTD/wt) and Flt3(ITD/wt) mutations induces spontaneous AML with an increase in DNA methyltransferases (Dnmt1, 3a, and 3b) and global DNA methylation index PMID: 24085765
23. Cooperation of MLL/AF10(OM-LZ) with KRASG12C increased cell adhesion via upregulation of an adhesion G-protein-coupled receptor Gpr125. PMID: 23564351
24. menin and MLL1 regulate distinct pathways during normal hematopoiesis, particularly in HSCs and B cells. PMID: 23908472
25. Data indicate that isruption of the MLL-PAFc subunit, Cdc73 (Hrpt2) interaction selectively inhibits the proliferation of MLL leukemic cells. PMID: 23900238
26. beta-catenin, CBP and Mll promote self-renewal and H3K4 tri-methylation in salivary gland tumour propagating cells. PMID: 23736260
27. Arginine methylation of Pax7 by Carm1 functions as a molecular switch controlling the epigenetic induction of Myf5 during satellite stem cell asymmetric division and entry into the myogenic program. PMID: 22863532
28. MLL1 is recruited to its target genes by activated NF-kappaB and regulates their transcription. PMID: 22623725
29. MLL-AF9 could not initiate leukemia in Bmi1(-/-)Hoxa9(-/-) mice, which have further compromised HSC functions. PMID: 21624810
30. This study demonstrated the predominant expression MEN1-related genes, particularly MLL and p27, in the endocrine organs, and a tissue-specific haploinsuffiency of MLL may lead to a decrease in levels of p27 and p18 mRNAs in endocrine organs. PMID: 22037578
31. The dissociated MLL subunits are subjected to distinct degradation pathways and thus not likely to have separate functions unless the degradation mechanisms are inhibited. PMID: 21670200
32. H3K4 trimethylation by MLL1 is required to establish a permissive chromatin state for circadian transcription. PMID: 21113167
33. Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis. PMID: 20724987
34. results identify MLL as a key constituent of the mammalian DNA damage response pathway PMID: 20818375
35. MLL interacts directly with the polymerase associated factor complex (PAFc) via Paf1 and CTR9. PAFc augments MLL and MLL-AF9 mediated transcriptional activation of Hoxa9 and their interaction is essential for leukemogenesis. PMID: 20541477
36. Specific recruitment of MLL1 requires multiple interactions and is a precondition for stable recruitment of MLL1 fusion proteins to HoxA9 in leukemogenesis. PMID: 20541448
37. DNA binding by the CXXC domain of MLL, and protection against DNA methylation is essential for MLL fusion leukemia. PMID: 20010842
38. molecular crosstalk between aberrant expression of Hox molecule(s) and activated Raf may have a key role in the MLL-fusion-mediated-leukemogenesis PMID: 19710696
39. the MLL-AFX fusion protein transforms myeloid progenitors and interferes with forkhead protein function PMID: 12192052
40. mechanism for oncogenic activation of MLL by forkhead family proteins designated FKHRL1 and AFX PMID: 12393557
41. the MLL SET domain is a histone H3 lysine 4-specific methyltransferase whose activity is stimulated with acetylated H3 peptides PMID: 12453418
42. existence in fused form with eleven nineteen leukemia disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell PMID: 12642866
43. Microarray hybridization experiments revealed 197 potential target genes that are differentially expressed, providing new and important clues about MLL functions. PMID: 12789274
44. RNAi-mediated knockdown of Taspase1 results in the appearance of unprocessed MLL and the loss of proper HOX gene expression PMID: 14636557
45. impact of Hoxa7 or Hoxa9 nullizygosity on hematopoietic progenitor compartments and their susceptibility to MLL-induced leukemias PMID: 15070702
46. Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis. Review. PMID: 15132992
47. the CXXC DNA binding domain has a critical role in MLL-associated oncogenesis, most likely via epigenetic recognition of CpG DNA sites within the regulatory elements of target genes PMID: 15542854
48. A permissive cellular environment is required for oncogenicity of Mll-associated translocations and Mll fusions can influence haematopoietic lineage commitment. PMID: 16096649
49. A disruption of the Sept6, the translocation partner gene of MLL in 11q23 translocation, does not contribute to leukemogenesis by the MLL fusion gene. PMID: 16314519
50. major function of Mll is to act at the chromatin level to sustain the expression of selected target Hox genes during embryonic development PMID: 16618927

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STRING: 10090.ENSMUSP00000002095

UniGene: Mm.2389