Recombinant Mouse Homeobox protein Hox-A13 (Hoxa13)

1. we report on the genome-wide profiling of HOXA13 and HOXD13 in vivo binding and changes of the transcriptome and chromatin state in the transition from the early to the late-distal limb developmental program, as well as in Hoxa13(-/-); Hoxd13(-/-) limbs. PMID: 27974206
2. Data show that almost all muscle masses of the zeugopod (forearm) and part of the triceps contain homeobox protein HOXA13-expressing cells and/or their descendants. PMID: 25980463
3. Defects in interdigital programmed cell death and digit separation in Hoxa13 mutant mice may be caused in part by reduced levels of RA signaling stemming from a loss in the direct regulation of Aldh1a2 PMID: 23553814
4. The data demonstrate that simvastatin contributes to prevent the progression of renal fibrosis by upregulating BMP-7-mediated anti-fibrotic signaling and that one aspect of crucial efficacies is achieved by regulating HOXA13 and USAG-1. PMID: 22525429
5. The results show that overactivation of hedgehog signaling leads to abnormal development of the female reproductive tract, altered levels of Hoxa13 and Wnt5a mRNA, and an aberrant inflammatory response to mating. PMID: 21809434
6. Data show that cis-regulatory elements driving Hoxd gene expression in distal limbs are present in fish. PMID: 21765002
7. specific role during appendicular skeletal development PMID: 20034107
8. complete NMR chemical shift assignments of the mouse HOXA13 DNA binding domain PMID: 19888690
9. HoxA-13 regulates transcription through multiple pathways PMID: 12771139
10. Hoxa13 has a role in the vascularization of the glans penis is also identified PMID: 12783783
11. Immunoprecipitation of HOXA13-bone morphogenetic protein 2 and HOXA13-bone morphogenetic protein 7 enhancer complexes from the developing autopod confirm that endogenous HOXA13 associates with these regions PMID: 15342482
12. Microarray analysis identified 68 genes with significant, reproducible RNA expression changes in stable HOXA13-expressing cells. PMID: 15733672
13. the high affinity HOXA13 binding site deduced by quantitative analyses is used in vivo to facilitate HOXA13 target gene regulation, providing a critical advance toward understanding the molecular basis for defects associated with loss of HOXA13 function PMID: 17200107
14. The distal-specific gene HOXA13 is continually required to maintain the distal-specific transcriptional program in adult fibroblasts PMID: 18245445
15. At least two sequences remote to the HoxA cluster are required collectively to drive Hoxa13-like expression in developing distal limbs. PMID: 18638319
16. the antagonistic interaction between Hoxa13-Hoxd13 and Sall1-Sall3 in the developing limb may contribute to the fine-tuning of local Hox activity that leads to proper morphogenesis of each cartilage element of the vertebrate autopod. PMID: 19168674

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KEGG: mmu:15398

STRING: 10090.ENSMUSP00000039170

UniGene: Mm.377086