Recombinant Mouse Homeobox protein Meis1 (Meis1)

1. the role of Meis1 in sensorimotor gating and in the dopaminergic systems modulating it, is reported. PMID: 28645892
2. Results show Meis1 Is expressed in normal and aberrant ducts, pancreatic intraepithelial neoplasia, and pancreatic ductal adenocarcinoma and that its expression increases cell migration in pancreatic cancer through transcriptional activation of Mcam. PMID: 27583552
3. the Hoxa9- and Meis1-associated upregulation of Flt3 is a passive event with regard to leukemia development in mice and with limited relevance to the AML pathology. PMID: 27617578
4. we show that simultaneous deletion of Meis1 and Meis2 in presumptive lens ectoderm results in arrested lens development in the pre-placodal stage, and neither lens placode nor lens is formed. We found that in the presumptive lens ectoderm of Meis1/Meis2 deficient embryos Pax6 expression is absent PMID: 27918583
5. Meis1 is a major regulator of sympathetic target-field innervation and Meis1 deficient sympathetic neurons die by apoptosis from early embryonic stages to perinatal stages. PMID: 26857994
6. PCBP2 overexpression rescues the Meis1 effects of Akt-mTOR pathway and hypertrophy of cardiomyocytes. PMID: 26597775
7. Data indicate roles of myeloid ecotropic viral integration site 1 protein (Meis1) in both megakaryopoiesis and erythropoiesis. PMID: 26986211
8. Sequential binding of MEIS1 and NKX2-5 on the Popdc2 gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis. PMID: 26411676
9. Pbx3 contributes to Hoxa9 leukemogenesis through stabilization of the Meis1 protein. PMID: 25911551
10. data point to role of Meis1 in striatal development, also supported by reduced neuronal differentiation in the lateral ganglionic eminence of Meis1(-/-) embryos PMID: 26511239
11. Meis1 is at the core of a genetic network implicated in eye patterning/microphthalmia. PMID: 26253404
12. Data indicate that Meis homeobox 1 (MEIS1) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF)is a key downstream mediator of Meis1. PMID: 25740828
13. Meis1 regulates epidermal stem cells and is required for skin tumorigenesis. PMID: 25013928
14. Meis1 is potentially involved in the maintenance of postnatal thymic epithelial cell. PMID: 24594519
15. deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis PMID: 24809472
16. Data indicate that loss of homeodomain transcription factor Meis1 leads to a depletion of hematopoietic progenitor cells from the bone marrow. PMID: 24498346
17. vivo and in vitro analysis of a common SNP with small effect size showed allele-dependent function in the prospective basal ganglia representing the first neurodevelopmental region implicated in Restless Legs Syndrome. PMID: 24642863
18. results suggest a previously unidentified role for C/EBPalpha in maintaining the proliferation required for Hoxa9/Meis1-mediated leukemogenesis PMID: 24958854
19. we detected MEIS1 expression in primary cultures of in vivo differentiated cortical neurons and astrocytes PMID: 23756022
20. Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis. PMID: 24578510
21. results imply that crosstalk between Oct4 and Meis1a on mutual gene expressions is essential for the determination of NE from EC cells PMID: 23451132
22. There is direct yet differential regulation of meis1 transcription by Gfi1b in distinct hematopoietic lineages. PMID: 23308270
23. results identify Meis1 as a critical transcriptional regulator of cardiomyocyte proliferation and a potential therapeutic target for heart regeneration PMID: 23594737
24. Data have demonstrated the presence of Meis, Pbx, and Prep proteins during early lineage segregation in mammals: Meis1, Meis3, Pbx1, Pbx2, Pbx3, and Prep1 in the mouse. PMID: 22987645
25. Meis1 deletion led to the accumulation of reactive oxygen species in hematopoietic stem cells and decreased expression of genes implicated in hypoxia response. PMID: 23091297
26. Loss of Meis1 results in down-regulation of both Hif-1 alpha and Hif-2 alpha in hematopoietic stem cells. PMID: 22995899
27. overexpression of Meis1 repressed the development of early erythroid progenitors, acting in vivo at the megakaryocyte-erythroid progenitor stage to skew development away from erythroid generation and toward megakaryocyte development PMID: 22665933
28. Data show that Meis1d, a Meis1 isoform, is expressed in colon. PMID: 21858198
29. During normal differentiation the Hoxa cluster, Pbx1 and Meis1 predominated, with a marked reduction in the majority of Hox genes and Meis1 occurring during hematopoietic commitment. PMID: 21083428
30. The C-terminal domain of MEIS1 confers to PKNOX1 an ectopic transactivating function that promotes leukemogenesis by regulating expression of genes involved in chromatin accessibility and cell cycle progression. PMID: 21900201
31. Meis1 disrupts the genomic imprint of Dlk1 in a NUP98-HOXD13 leukemia model. PMID: 20739957
32. GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, which in turn facilitates HOX-mediated transcription and transformation. PMID: 20541704
33. Meis1 over expression is associated with defective cell-cycle entry and transcriptional regulation of cyclin D3 leading to leukemogenesis. PMID: 20237320
34. Data show that during limb development, Pbx1 nuclear expression correlates with the Meis expression domain. PMID: 19247936
35. Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. PMID: 12082612
36. We have isolated a Meis1a transgenic mouse line exhibiting recessive male-specific lethality and non-alcoholic fatty liver disease (NAFLD), which coincides with pubescence and is androgen-dependent. PMID: 12374767
37. The mRNA level of this protein was elevated in limb buds after treatment with retinoic acid. PMID: 12397630
38. transplantation of bone marrow cells cotransduced with NUP98-HOXD13 and the HOX cofactor Meis1 rapidly caused lethal and transplantable acute myeloid leukemia PMID: 12543865
39. Hoxa9 and Hoxa7 as well as the Hox coregulators Meis1 and Pbx3 among the targets upregulated by MLL-ENL-ERtm in conditionally transformed cells PMID: 14701735
40. Meis1 knockout mice embryos have hematopoietic, angiogenic and eye defects. PMID: 14713950
41. MEIS C termini possess transcriptional regulatory domains that respond to cell signaling and confer functional differences between MEIS and PREP proteins PMID: 15654074
42. transcription factor oncoprotein (Meis1) establishes expression of a tyrosine kinase oncoprotein (FLT3) PMID: 15755900
43. Meis1 has a critical role in hematopoiesis and vascular patterning in the mouse embryo PMID: 15882575
44. the transforming property of Meis1 is modulated by 3 conserved domains, namely the Pbx interaction motif (PIM), the homeodomain, and the C-terminal region PMID: 16469876
45. These results suggest that c-Myb is essential but not sufficient for Hoxa9/Meis1 mediated transformation. PMID: 16507773
46. Persistent transactivation by Meis1 replaces hoxa9 function in myeloid leukemogenesis models. PMID: 16648484
47. Coexpression of the Hox cofactor Meis1a accelerates the Cdx4 AML phenotype and renders it fully penetrant. PMID: 17068127
48. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. PMID: 17942707
49. Retinal progenitor cells (RPCs) in chicks and mice express two Hth-related proteins, Meis1 and Meis2. PMID: 18216174
50. Novel collaboration between Icsbp deficiency and Meis1/Meis3 in the acceleration of chronic myeloid leukemia-like disease. PMID: 18223676

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KEGG: mmu:17268

STRING: 10090.ENSMUSP00000099942

UniGene: Mm.356578