Recombinant Mouse Homeobox protein TGIF1 (Tgif1)

1. Proteomic analyses show that HOXA1 physically interacts on chromatin with PBX, MEIS, and PREP family members, but not with TGIF, suggesting that TGIF may have an independent input into HOXA1-bound regions.complex cross-regulatory network of HOXA1 and TALE proteins. This study provides new insight into a regulatory network involving combinatorial interactions between HOXA1 and TALE proteins PMID: 28784834
2. Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. PMID: 27956704
3. loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2 PMID: 27187787
4. Tgif2 participates in photoreceptor cell differentiation in the early stages of retinal development and regulates proper subretinal localization of the cone photoreceptors. PMID: 27639517
5. Tgif1 suppresses stem cell self-renewal. PMID: 24100014
6. The identification and characterization of the Tgif mutant supports the role of TGFbeta signalling in the development of chronic OM. PMID: 23459932
7. Tgif1 mutation in mouse contributes to Holoprosencephaly pathogenesis due to disruption of the Shh pathway PMID: 22383895
8. TGIF1 plays a role in TNF-alpha- and radiation-induced inflammation and it could be a target in limiting this event in the vascular compartment PMID: 22995913
9. TGF-beta/Smad co-repressor TGIF1 plays a role in radiation-induced normal tissue damage by a Smad-independent mechanism. PMID: 22567107
10. Data suggest that in the absence of Tgif1, a persistent increase in TGFbeta responsive transcription and a reduced ability to deal with hyperoxic stress result in premature senescence in primary MEFs. PMID: 22514746
11. Tgif1 can regulate nuclear receptor complexes, in addition to those containing retinoic acid receptors, but also indicates that there is some specificity to which NR target genes are repressed by Tgif1. PMID: 20506222
12. Data show that loss-of-function mutations in both Tgif1 and Tgif2 result in a failure of gastrulation. PMID: 20040491
13. Targeted disruption of Tgif in mice did not induce discernible derangements in forebrain, which point to a possible functional redundancy of Tgif, potentially provided by the closely related Tgif2. PMID: 15831469
14. loss of TGIF function is compensated by other TGF-beta antagonists such as c-Ski and SnoN during vertebrate anterior neural development PMID: 16284942
15. TGIF acts as a transcriptional corepressor, which regulates developmental signaling by retinoic acid, and raises the possibility that TGIF may repress other RXR-dependent transcriptional responses. PMID: 16428452
16. Developmental control of proliferation by Tgif may play a role in the pathogenesis of Holoprosencephaly. PMID: 16705179
17. Deletion of the third exon of Tgif gene resulted in a defined spectrum of brain developmental defects, and serve as a useful model to unravel the genetic complexity implicated in the pathogenesis of holoprosencephaly. PMID: 17082251
18. Forced expression of exogenous TGIF repressed both endogenous and overexpressed Smad2/3-mediated promoter activity in 3T3-L1 PMID: 18310014
19. TGIF is essential for EGF-mediated downregulation of tropoelastin expression PMID: 18441095
20. Tgif functions in the normal development of the placenta, and suggest a role for maternal factors in regulating the morphogenesis of embryonically-derived placental tissues. PMID: 18508043

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KEGG: mmu:21815

STRING: 10090.ENSMUSP00000130930

UniGene: Mm.101034