Recombinant Mouse Inositol hexakisphosphate kinase 3(Ip6k3)

Code CSB-YP011772MO
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Source Yeast
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Code CSB-EP011772MO
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Source E.coli
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Code CSB-EP011772MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011772MO
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Source Baculovirus
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Code CSB-MP011772MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ip6k3
Uniprot No. Q8BWD2
Alternative Names Ip6k3; Ihpk3; Inositol hexakisphosphate kinase 3; InsP6 kinase 3; EC 2.7.4.21; Inositol hexaphosphate kinase 3
Species Mus musculus (Mouse)
Expression Region 1-396
Target Protein Sequence MVVRHSSDKG KIGVGVPLEP FLHQVGGHLS VLQYDAYTVC KPLVSQEQKF YESLPLAMKC FTPKYKGTIT VRLRRDSRGH LGLVANPLKE NLEPFQVSPE SRAVALWQTL QQTTGSESSP CPLTQLARSL KESAAKVLLR SDCHLSTQAS PLVESEDGSQ VERKGFNPWG LHCHQAHLTR LCSQYPEDKR HRFLLLENVV SQYKQPCILD LKMGTRQHGD DASEEKKARH MKKCAQSTSA CLGVRICGMQ VYQTDQKSFL CKDKYYGRKL SVEGFRQALS QFLHDGTRLR AELLEPILRR LQALLTVIRS QSSYRFYSSS VLIIYDGEPP QTTQGSTSGG VTSGDPAKVD VRMIDFAHTT FKGSWNEHTT YEGPDPGYIF GLENLIGILR DIQEGE
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Gene References into Functions
  1. High levels of IP6K3 mRNA were found in myotubes and muscle tissues. Expression was elevated under diabetic, fasting, and disuse conditions in mouse skeletal muscles. Ip6k3(-/-) mice had lower blood glucose, less insulin, decreased fat, lower weight, increased plasma lactate, enhanced glucose tolerance, lower glucose during an insulin tolerance test, and reduced muscle Pdk4 expression. Ip6k3 deletion extended lifespan. PMID: 27577108
  2. IP6K3 is highly expressed in cerebellar Purkinje cells. IP6K3-deleted mice display defects of motor learning and coordination. IP6K3-null mice manifest aberrations of Purkinje cells with a diminished number of synapses. PMID: 26245967
Subcellular Location Cytoplasm.
Protein Families Inositol phosphokinase (IPK) family
Tissue Specificity Highly expressed in cerebellum, brain cortex, kidney, thymus and lung. Detected at lower levels in hippocampus, testis, heart and olfactory bulb.
Database Links

KEGG: mmu:271424

STRING: 10090.ENSMUSP00000025046

UniGene: Mm.209679

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Address
7505 Fannin St. Ste 610-312, Houston, TX 77054, USA
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