Recombinant Mouse Jun dimerization protein 2 (Jdp2)

1. Female JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litters, and early reproductive senescence. JDP2 null females had increased levels of circulating FSH and higher expression of the Fshb subunit in the pituitary, resulting in elevated serum estrogen and higher numbers of large ovarian follicles PMID: 28007961
2. JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands. PMID: 28146118
3. High JDP2 expression in the bone marrow contributes to metastatic spread in the lung. PMID: 26497998
4. results suggest a negative feedback loop between JDP2 and p53, and a direct link between JDP2 and a key oncogenic pathway PMID: 25026555
5. Tbx3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2. PMID: 24394418
6. Using transgenic mice overexpressing the AP-1 inhibitor JDP2, a central role of AP-1 in the induction of hypertrophy and apoptosis in cardiomyocytes is demonstrated. PMID: 23612584
7. Jdp2 transcriptionally regulates the Trp53 promoter, via an atypical AP-1 site, and Jdp2 expression negatively regulates Trp53 expression levels; a genetic mechanism for tumour formation in the context of Trp53 heterozygosity PMID: 22370638
8. the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism. PMID: 22989952
9. Jdp2 plays pivotal roles in in vivo bone homeostasis and host defense by regulating osteoclast and neutrophil differentiation. PMID: 23200825
10. JDP2 phosphorylation by JNK results in rapid JDP2 destabilization and reduced expression levels following various cell stimuli PMID: 21463260
11. transcription of the gene for cyclin-A2 appears to be a direct target of JDP2 in the suppression of cell proliferation PMID: 20802531
12. JDP2 expression may play a critical role in liver cancer development. PMID: 20214788
13. JDP2, repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.JDP2 is key factor that controls the commitment of F9 cells to differentiation and shed light on AP-1 repressor functions PMID: 12052888
14. JDP2 protein plays a major role in promoting skeletal muscle differentiation via its involvement in cell cycle arrest and activation of the myogenic program PMID: 12171923
15. characterization of binding sites for stress mitogen-activated protein kinases on JDP2 PMID: 12225289
16. Results suggest that Jun dimerization protein 2 (JDP2) may play an important role in the RANK-mediated signal transduction system, especially in osteoclast differentiation. PMID: 12707301
17. c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene PMID: 14627710
18. Fos/Jdp2/Batf locus is associated with SL3-3 mouse leukemia virus B cell lymphoma. PMID: 15913695
19. JDP2 inhibited both the acetylation of histone H3 in the promoter of the gene for C/EBPdelta and transcription from this promoter. PMID: 17464331
20. Results indicate that JDP2 is involved in the signaling pathway for senescence via epigenetic regulation of the expression of the gene for p16(Ink4a). PMID: 19233846

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KEGG: mmu:81703

STRING: 10090.ENSMUSP00000059724

UniGene: Mm.103560