Jdp2 Antibody

Code CSB-PA011945XA01MO
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Jdp2 Polyclonal antibody
Uniprot No. P97875
Target Names Jdp2
Alternative Names Jdp2 antibody; Jundm2 antibody; Jun dimerization protein 2 antibody
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Immunogen Recombinant Mus musculus (Mouse) Jdp2 protein
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Gene References into Functions
  1. Female JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litters, and early reproductive senescence. JDP2 null females had increased levels of circulating FSH and higher expression of the Fshb subunit in the pituitary, resulting in elevated serum estrogen and higher numbers of large ovarian follicles PMID: 28007961
  2. JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands. PMID: 28146118
  3. High JDP2 expression in the bone marrow contributes to metastatic spread in the lung. PMID: 26497998
  4. results suggest a negative feedback loop between JDP2 and p53, and a direct link between JDP2 and a key oncogenic pathway PMID: 25026555
  5. Tbx3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2. PMID: 24394418
  6. Using transgenic mice overexpressing the AP-1 inhibitor JDP2, a central role of AP-1 in the induction of hypertrophy and apoptosis in cardiomyocytes is demonstrated. PMID: 23612584
  7. Jdp2 transcriptionally regulates the Trp53 promoter, via an atypical AP-1 site, and Jdp2 expression negatively regulates Trp53 expression levels; a genetic mechanism for tumour formation in the context of Trp53 heterozygosity PMID: 22370638
  8. the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism. PMID: 22989952
  9. Jdp2 plays pivotal roles in in vivo bone homeostasis and host defense by regulating osteoclast and neutrophil differentiation. PMID: 23200825
  10. JDP2 phosphorylation by JNK results in rapid JDP2 destabilization and reduced expression levels following various cell stimuli PMID: 21463260
  11. transcription of the gene for cyclin-A2 appears to be a direct target of JDP2 in the suppression of cell proliferation PMID: 20802531
  12. JDP2 expression may play a critical role in liver cancer development. PMID: 20214788
  13. JDP2, repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.JDP2 is key factor that controls the commitment of F9 cells to differentiation and shed light on AP-1 repressor functions PMID: 12052888
  14. JDP2 protein plays a major role in promoting skeletal muscle differentiation via its involvement in cell cycle arrest and activation of the myogenic program PMID: 12171923
  15. characterization of binding sites for stress mitogen-activated protein kinases on JDP2 PMID: 12225289
  16. Results suggest that Jun dimerization protein 2 (JDP2) may play an important role in the RANK-mediated signal transduction system, especially in osteoclast differentiation. PMID: 12707301
  17. c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene PMID: 14627710
  18. Fos/Jdp2/Batf locus is associated with SL3-3 mouse leukemia virus B cell lymphoma. PMID: 15913695
  19. JDP2 inhibited both the acetylation of histone H3 in the promoter of the gene for C/EBPdelta and transcription from this promoter. PMID: 17464331
  20. Results indicate that JDP2 is involved in the signaling pathway for senescence via epigenetic regulation of the expression of the gene for p16(Ink4a). PMID: 19233846

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Subcellular Location Nucleus.
Protein Families BZIP family, ATF subfamily
Tissue Specificity Ubiquitously expressed in all adult tissues tested as well in embryos.
Database Links

KEGG: mmu:81703

STRING: 10090.ENSMUSP00000059724

UniGene: Mm.103560

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