Recombinant Mouse Kinase suppressor of Ras 1 (Ksr1), partial

1. DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF. PMID: 27368419
2. praja2 regulates KSR1 stability and mitogenic signaling. PMID: 27195677
3. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding. PMID: 28003362
4. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras. PMID: 25002533
5. propose that phosphorylation of Tyr(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses PMID: 24158441
6. Data indicate that phosphorylation of BRAF by AMPK disrupts its association with KSR1. PMID: 24095280
7. Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation. PMID: 23431403
8. Ksr1 plays a dispensable role in lipopolysaccharide (LPS)-induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model. PMID: 23221422
9. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane. PMID: 23250398
10. The loss of Ksr1 inhibits Ras/Mapk pathway signaling leading to increased Myc-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development. PMID: 22301919
11. a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1 PMID: 22206009
12. Genetic disruption of KSR1 results in striking reductions in kit-ligand-mediated proliferation & degranulation and impacts the biochemical activation of p21-activated kinase. PMID: 21726514
13. Data suggest that feedback phosphorylation of KSR1 prevents excessive ERK1/2 signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability. PMID: 21471251
14. findings suggest that Ksr1 functions as a previously unknown scaffold that enhances iNOS activity and is therefore crucial for the pulmonary response to P. aeruginosa infections PMID: 21297617
15. KSR1 is a functional protein kinase, MEK1 is an in vitro substrate of KSR1, and the catalytic activities of both proteins are required for eliciting cell survival responses downstream of TNF. PMID: 21144847
16. despite a requirement for KSR1 for full ERK activation in thymocytes, full and efficient ERK activation is not essential for the majority of thymocyte selection events. PMID: 20865788
17. Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor. PMID: 11751383
18. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo PMID: 11940661
19. evidence for interaction of Nm23-H1 and the suppressor of kinase Ras(KSR)in mammalian cells; can phosphorylate KSR via a histidine-dependent pathway PMID: 12105213
20. Effects of prenyl pyrophosphates on the binding of S-Ras proteins with KSR PMID: 12410604
21. KSR1 permits coupling of ROCK to the actin polymerization machinery and its effects are mediated by the C-terminal domain of KSR1 PMID: 12588996
22. molecular scaffold KSR1 regulates the intensity and duration of ERK activation to modulate a cell's proliferative and oncogenic potential PMID: 15121859
23. Data demonstrate that phosphorylation and stability of the molecular scaffold KSR1 are critical regulators of growth factor-specific responses that promote cell proliferation. PMID: 15371409
24. KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways PMID: 15520859
25. Deletion of KSR1 prevents adipogenesis in vitro, which can be rescued by introduction of low levels of KSR1 PMID: 16107706
26. KSR1 is a member of a unique class of proteins whose deletion blocks both cell senescence and transformation PMID: 16507997
27. absence of KSR1 leads to deficits in associative learning and theta burst stimulation-induced LTP PMID: 16731514
28. KSR1 as a caspase target and suggest that cleavage of the KSR1 scaffold represents another mechanism whereby caspases down-regulate ERK survival signaling to promote cellular apoptosis. PMID: 17613518
29. NM23-H1 and its interacting partner STRAP physically interact with p53 and positively regulate its functions, including p53-induced apoptosis and cell cycle arrest PMID: 17916563
30. KSR1 is recruited to the immunological synapse during T-cell activation; membrane recruitment of KSR1 is required for recruitment of active ERK to the synapse. PMID: 19139278
31. a specific role for the molecular scaffold KSR1 and KSR1-mediated ERK signaling in the cellular response to DNA interstrand cross-links. PMID: 19147494
32. These findings provide unique insight into the signaling dynamics of the KSR1 scaffold. PMID: 19541618

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KEGG: mmu:16706

STRING: 10090.ENSMUSP00000018478

UniGene: Mm.4745