Recombinant Mouse Kinesin-like protein KIF3A (Kif3a)

1. KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma PMID: 29156524
2. Cell senescence is a central feature in nephronophthisis type 7 and Kif3a is unexpectedly required for efficient DNA damage response and cell cycle arrest. PMID: 27181777
3. The results show for KIF3AB that the kinetics of microtubule association is less than the rates observed for KIF3AA or KIF3BB. PMID: 27637334
4. genetically ablated Kif3a, Ift88, and Ttc21b in a series of specific spatiotemporal domains. The resulting phenotypes allow us to draw several conclusions. First, we conclude that the Ttc21b cortical phenotype is not due to the activity of Ttc21b within the brain itself PMID: 28291836
5. Airway epithelial KIF3A suppresses Th2 pulmonary inflammation and airway hyperresponsiveness following aeroallergen exposure, implicating epithelial microtubular functions in the pathogenesis of Th2-mediated lung pathology. PMID: 27794000
6. Longitudinal microcomputed tomography (muCT) imaging and histopathological analyses revealed an increased rate of cyst formation, increased proportion of cysts with proliferating cells, higher frequency of atypical cysts as well as the development of neoplasms in Vhl/Kif3a/Trp53 mutant kidneys compared to Kif3a/Trp53 or Vhl/Kif3a mutant kidneys. PMID: 27126173
7. Study found that both KIF3AC and KIF3AB can traverse long distances over the microtubule track, revealing that these motors are adept and well-tuned for their specialized roles as cargo transporters PMID: 26445448
8. Data suggest biocatalysis by Kif3a homodimer, Kif3c homodimer, or Kif3a/Kif3c heterodimer vary; microtubule interaction is very fast for Kif3a homodimer; Kif3c homodimer interaction is much slower; Kif3a/Kif3c heterodimer interaction is intermediate. PMID: 26710851
9. KIF1-binding protein interacts with KIF3A in haploid male germ cells, promoting spermatid elongation. PMID: 26245936
10. Vhl and Kif3a deletion accelerates renal cyst formation PMID: 25788526
11. The results of this study suggested thatactivity-dependent cargo loading, in which phosphorylation of the KIF3A C terminus upregulates the loading and transport of N-cadherin in homeostatic synaptic plasticity. PMID: 26335646
12. The results demonstrate that visual pigments transport to the retinal outer segment despite removal of KIF3 and IFT88, and KIF3-mediated anterograde IFT is responsible for photoreceptor transition zone and axoneme formation. PMID: 25825494
13. Processivity of the kinesin-2 KIF3A results from rear head gating and not front head gating. PMID: 25657001
14. A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a PMID: 24887031
15. KIF3AB exhibits novel ATPase activity. PMID: 25122755
16. single-molecule motility from different kinesin-1 and kinesin-2 neck-linker chimeras stepping along microtubules, was studied. PMID: 24739168
17. This study highlights the essential role of KIF3A-mediated microtubular transport in the development of spermatozoa and male fertility. PMID: 23831641
18. Kif3a controls nephron number via distinct cell lineage-specific mechanisms. PMID: 23762375
19. Thyroid-specific inactivation of KIF3A alters the TSH signaling pathway and leads to hypothyroidism. PMID: 23511952
20. findings show that KIF3a is necessary for medulloblastoma formation PMID: 23389290
21. in addition to its ciliogenic roles, Kif3a recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres. PMID: 23386061
22. Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia. PMID: 22357948
23. The Axin/TNKS2/KIF3A complex is critical for GLUT4 translocation in response to insulin. PMID: 22473005
24. Deletion of Kif3A reduces bone formation due to loading. PMID: 22428034
25. our data suggest that RNF33 most likely interacts with KIF3A-KIF3B independent of the adaptor kinesin-associated protein KAP3 PMID: 21909995
26. show that the microtubule motor subunit Kif3a regulates hair cell polarization through both ciliary and non-ciliary mechanisms PMID: 21752934
27. Kif3a and primary cilia are required for coordination of chondrocyte maturation, intramembranous bone formation, and chondrogenic condylar growth PMID: 21566205
28. Pkd1 and Kif3a counterbalance the regulation of osteogenesis and adipogenesis through differential regulation of Runx2 and PPARgamma by Gli2 PMID: 21151991
29. Epidermal cilia function was analyzed using conditional alleles of the ciliogenic genes Ift88 and Kif3a. PMID: 21429982
30. KIF3, cilia, and nodal flow have roles in left-right determination [review] PMID: 20066075
31. The dynamins comprise a large family of mechanoenzymes known to participate in membrane modeling events. All three conventional dynamin genes (Dnm1, Dnm2, Dnm3) are expressed in mammalian brain and produce more than 27 different dynamin proteins. PMID: 12646135
32. role in inhibiting renal ciliogenesis and produces polycystic kidney disease PMID: 12672950
33. insulin signaling stimulates Rab4 activity, the association of Rab4 with kinesin, the interaction of KIF3 with microtubules and this process is mediated by insulin-induced PI3-kinase-dependent PKC-lambda activation and participates in GLUT4 exocytosis PMID: 12832475
34. Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis. PMID: 16298999
35. Tissue-specific loss of Kif3a in pancreatic cells resulted in severe pancreatic abnormalities including acinar-to-ductal metaplasia, fibrosis, and lipomatosis. PMID: 17123526
36. Kif3a, a subunit of the Kinesin II motor complex, is required for intraflagellar transport and the formation of cilia. PMID: 17359961
37. Kif3a and primary cilia make unique contributions to cranial base development and synchondrosis growth plate function. PMID: 17507416
38. Gli1 transcript level is dramatically reduced, whereas Gli3 expression is not significantly affected by kinesin-2 depletion. However, the motor is required for the efficient cleavage of the full-length Gli3 transcription factor into a repressor form. PMID: 17698054
39. Results suggest that Kif3a restrains canonical Wnt signalling both by restricting the CKI-dependent phosphorylation of Dvl and through a separate ciliary mechanism. PMID: 18084282
40. Kidney-specific inactivation of Kif3a in newborn mice resulted in the loss of primary cilia and produced kidney cysts primarily in the loops of Henle. PMID: 18263895
41. findings indicate that, together, beta-arrestins and Kif3A may mediate the transport of Smo to the primary cilium PMID: 18497258
42. Disruption of FKBP8 function activates the Shh signaling pathway cell-autonomously dependent on the Gli2 transcription factor and kinesin-2 subunit Kif3a, a component of the intraflagellar transport machinery used to generate cilia. PMID: 18590716
43. effect of KIF3A deletion on transport of phototransduction proteins was studied in cone and rod photoreceptors; results indicate that trafficking of membrane proteins to the outer segment is dependent on kinesin-II in cone, but not rod photoreceptors PMID: 19906976

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KEGG: mmu:16568

STRING: 10090.ENSMUSP00000112782

UniGene: Mm.88694